Source light having a range of optical wavelengths is generated. The source light is split into sample light and reference light. The sample light is delivered into a sample, such that the sample light is scattered by the sample, resulting in signal light that exits the sample. The signal light and the reference light are combined into an interference light pattern having optical modes, each having a direct current (DC) component and at least one alternating current (AC) component. Different subsets of the optical modes of the interference light pattern are respectively detected, and analog signals representative of the optical modes of the interference light pattern are output. Pair of the analog signals are subtracted from each other, and differential analog signals are output. The sample is analyzed based on the differential analog signals.

A surgical visualization system is disclosed. The surgical visualization system is configured to identify one or more structure(s) and/or determine one or more distances with respect to obscuring tissue and/or the identified structure(s). The surgical visualization system can facilitate avoidance of the identified structure(s) by a surgical device. The surgical visualization system can comprise a first emitter configured to emit a plurality of tissue-penetrating light waves and a second emitter configured to emit structured light onto the surface of tissue. The surgical visualization system can also include an image sensor configured to detect reflected visible light, tissue-penetrating light, and/or structured light. The surgical visualization system can convey information to one or more clinicians regarding the position of one or more hidden identified structures and/or provide one or more proximity indicators.

An optical sensing apparatus includes a laser device, a photodetector, and a control circuit. The laser device includes a light source that emits laser light, a diffusing member having a diffusing surface that crosses an optical path of the laser light, the diffusing member making the laser light lower in intensity in a first portion, making the laser light higher in intensity in a second portion, and enlarging a beam diameter of the laser light, and a screen, and irradiates a physical object with the laser light having passed through the screen or the laser light reflected by the screen. The control circuit causes the laser device to irradiate the physical object with at least one optical pulse of the laser light and causes the photodetector to perform a time-resolved measurement of at least one reflected optical pulse of the laser light returning from the physical object.

A system and method for performing four dimensional multicolor nanotomography with high harmonics and attosecond pulses to attain spectrally resolved absorption data about the three-dimensional volumetric structure of a sample are disclosed. Also disclosed are embodiments of the system and method that have been adapted to perform four dimensional multicolor nanotomography absorption and index of refraction data about the three-dimensional volumetric structure of a sample, to perform five dimensional multicolor nanotomography with high harmonics and attosecond pulses to obtain spectrally resolved absorption data about the three-dimensional volumetric structure and temporal dynamics of the sample, to perform five dimensional multicolor nanotomography to obtain spectrally resolved absorption and index of refraction data about the three-dimensional volumetric structure and temporal dynamics of the sample, and to perform Fourier-domain Optical Coherence Tomography.

The present invention comprises: a light source; a generator that generates, from light generated by the light source, a light pulse train in which the carrier waves are coherent, interference between adjacent waveforms is low, and the spatial length of a pulse width is smaller than a depth range of an observation target region in a measurement target; a frequency shifter that converts the frequency of a light pulse train modulated by the generator; a light path length changing unit that changes the light path length of the light pulse train; a light detection unit into which is input the light pulse train output from the light path length changing unit and backwardly scattered waves from the measurement target; a filter that extracts a difference signal output from the light detector and having a shift frequency of the frequency shifter; a demodulator that combines the difference signal extracted by the filter and a reference signal synchronized with the shift frequency of the frequency shifter; and an analyzing unit that analyzes a signal output by the demodulator.

Systems for the monitoring of bacterial levels in samples, using spectral analysis of the light diffracted from a substrate with an ordered array of pores having diameters enabling the targets to enter them. The trapping pore array is cyclically illuminated by light of different wavelengths, and the light diffracted from the pore array is imaged by a 2-dimensional detector array, with one pixel, or a small group of pixels receiving light from each associated pore. The temporal sequence of frames provides a series of images, each from the reflection of a different wavelength. A time sequenced readout of the signal from the pixel or pixels associated with each pore region, provides a spectral plot of the reflected light from that pore region. Spectral analysis of the light intensity from this series of different wavelength enables the effective optical thickness (EOT) of each pore to be extracted.

The present invention relates to a high-speed imaging system for measuring a target object within a sample, comprising: a light source emitting a plane wave; an angle-adjustment mirror adjusting an angle of the plane wave emitted from the light source; an optical interferometer dividing the plane wave whose angle was adjusted by the angle-adjustment mirror into a reference wave and a sample wave and forming an interference wave between the reference wave reflected from a reference mirror and the sample wave reflected from the target object; a camera module obtaining the interference wave, and an imaging controller controlling the angle-adjustment mirror to adjust the angle of the plane wave sequentially, forming a time-gated reflection matrix by using the interference waves obtained by the camera module in accordance with each angle of the plane wave, and imaging the target object based on the time-gated reflection matrix.

An example forward scatter sensor comprises: a transmitter arranged to emit a single light sheet; a receiver to observe light scattered from particles that fall through a measurement volume; and a control entity comprising an analyzer arranged to record a measurement signal descriptive of intensity of light captured by the receiver as a function of time and to carry out a precipitation analysis on basis of a time segment of the measurement signal, the precipitation analysis comprising: identifying, in said time segment, one or more double peaks that each represent a respective droplet and comprise a first peak that represents light refracted from a bottom of the respective droplet upon entry to the measurement volume and a second peak that represents light reflected from a top of the respective droplet upon exit from the measurement volume; and deriving one or more precipitation parameters and one or more precipitation indications.

An emitter assembly and waveform sensor assembly for visualizing a target is disclosed. The emitter assembly is configured to emit electromagnetic radiation and includes a first emitter configured to emit at least one of visible light, infrared radiation, or a combination thereof and a second emitter configured to emit structured electromagnetic radiation. The waveform sensor assembly is configured to detect the electromagnetic radiation emitted by the emitter assembly and obtain three-dimensional images corresponding to the detected electromagnetic radiation.

A surgical access assembly comprises a trocar and a surgical instrument. The trocar comprises a housing and an access tube extending distally from the housing. The housing comprises a hollow light emitter. The housing and the access tube define a lumen extending through the housing and the access tube. The hollow light emitter is configured to project light in the lumen. The surgical instrument comprises an end effector and a shaft extending proximally from the end effector. The shaft comprises an optical receiver positioned within reach of the light from the hollow light emitter. The shaft further comprises a light guide extending from the optical receiver along at least a portion of the shaft toward the end effector.