According to one embodiment of the present invention, a structure includes: a substrate having a patterned surface of one or more binding sites; and a molecular shape made by a polynucleotide platform having a shape corresponding to a shape of a binding site of the one or more binding sites, the molecular shape being bound to one of the one or more binding sites.

Device (1) for characterizing a substance (2) capable of emitting a photoluminescence radiation (Rp) in a first spectral range, the device (1) comprising: an electroluminescent component (3), at least semi-transparent in the first spectral range, and comprising first and second opposite surfaces (30, 31), the electroluminescent component (3) being suitable for emitting an excitation radiation (Re.sub.1) outgoing from the first surface (30), emitted in a first spectral range according to a circular polarization state; the excitation radiation (Re.sub.1) outgoing from the first surface (30) being able to pass through the electroluminescent component (3), after being reflected, and exit from the second surface (31); a polarization filter (4), arranged to filter the excitation radiation (Re.sub.2) outgoing from the second surface (31), and suitable for modifying the circular polarization state so as to obtain an extinguishing of the excitation radiation (Re.sub.2) outgoing from the second surface (31) of the electroluminescent component (3); a detector (5), arranged to detect the photoluminescence radiation (Rp) outgoing from the polarization filter (4).

Analyte collection and testing systems and methods, and more particularly to disposable oral fluid collection and testing systems and methods. Described herein are methods and apparatuses to achieve significant improvements in the detection of fluorescence signals in the reader.

A system and a method directed to a monitoring system of semiconductor processing chambers is provided. In particular, monitoring of any chemical formation on a chamber and a wafer of a semiconductor processing chamber using in-situ laser induced fluorescence is provided. The monitoring system and method detect issues before they become a problem for the semiconductor processing chambers by providing diagnosis on chamber health and mechanisms for associated process shifts with a faster turnaround time.

The invention relates to an apparatus (100) and method for Raman, photoluminescence or fluorescence spectroscopy.

According to the invention, the apparatus comprises an optical device (16) for polarisation splitting and modification, comprising a polarization splitter (18) and a compensator (17), the optical device (16) being configured and oriented to split the incident light beam (20) emitted onto the diffraction grating (12) into a first part (21) of the emitted light beam that is polarised according to a first polarisation state and a second part (22) of the emitted light beam that is polarised according to a second polarisation state, and the detection system (13) being suitable for receiving, in a first detection area (14), a spectrum of the first part (21) of the emitted light beam and, simultaneously, in a second detection area (15), a spectrum of the second part (22) of the emitted light beam.

A degree of polarization of second reference samples produced by adding an antibody, a tracer, and a target substance having mutually different concentrations to a first reference sample not including the target substance is corrected with a degree of polarization of the first reference sample to generate a first calibration curve. A degree of polarization of a second sample to be measured produced by adding the antibody and the tracer to a first sample to be measured in amounts equal to those added to the second reference samples is corrected with a degree of polarization of the first sample to be measured to obtain the concentration of the target substance in the first calibration curve.

A bio-detection device is provided. The bio-detection device includes a plurality of pixel units. Each of the pixel units includes a substrate, one or more pairs of reflective sub-polarizing units, and a plurality of reaction sites. The pairs of reflective sub-polarizing units are disposed on the substrate. The difference of the absolute value between respective polarizing angles of the reflective sub-polarizing units in each pair of reflective sub-polarizing units is 90. The reaction sites are defined above the one or more pairs of reflective sub-polarizing units. The reaction sites and the reflective sub-polarizing units are in one-to-one correspondence.

Methods for preparing a personalized cancer vaccine and a method to train a machine learning HLA-peptide presentation prediction model. Further wherein, a method of making a HLA class II tetramer or multimer comprising an epitope, the method comprising contacting a purified soluble HLA-DM loaded with a peptide epitope with a HLA class II tetramer or multimer, thereby forming a HLA class II tetramer or multimer loaded with the peptide epitope, is disclosed.

To provide a method of detecting a target substance in which silica particles are used, and a sensitizing factor is increased without any reduction in measurement accuracy, provided is a method of detecting a target substance including: a first step of mixing a specimen liquid containing at least the target substance and a particle dispersion, which comprises first particles each having a site that specifically binds to the target substance, to produce a liquid sample; and a second step of performing the optical measurement of the liquid sample, wherein the liquid sample comprises second particles, wherein the ratio of the average particle diameter of the second particles to the average particle diameter of the first particles in the liquid sample is 0.03 or more and 0.24 or less, and wherein the refractive index of the second particles is smaller than the refractive index of the first particles.

An example apparatus comprises a chamber with a reaction region, the reaction region including a heater disposed within the chamber, and a set of capture agents immobilized on a surface associated with the chamber and disposed proximal to the heater. The apparatus further includes a microfluidic channel coupled to the chamber to flow fluid to the chamber, the fluid including a reagent mix including a set of sense agents bound to fluorophores and a set of reaction agents and a sample fluid including a target.