A point of use analyte detection and quantification system for food or food processing applications is provided. Related methods are also provided.

A device including a housing, a zone and a means for testing a fluid sample within the housing is disclosed. The housing is constructed of a fluid impermeable material, and defines a first fluid port, and a second fluid port. The first fluid port is configured to connect to a fluid collection device to receive a fluid sample from the fluid collection device into the housing. The second port is configured to pass the fluid sample from the housing into a testing instrument. The zone is formed in the housing. The zone is constructed of a material that allows an analysis of the fluid sample positioned within the housing, and located adjacent to the zone.

A method for evaluating a test article provided by a subject for an attribute, such as a medical, industrial, veterinary, agricultural, food, or other attribute, is provided. The design includes providing a cassette comprising at least one ligand selected to match the attribute, applying the test article provided by the patient to the at least one ligand of the cassette, transmitting light energy toward the test article applied to the at least one ligand, sensing optical attributes of light energy provided from the test article applied to the at least one ligand, and providing sensed attributes of the light energy sensed to an electronic device.

A component measurement system (10) includes a test strip (12) that includes a main body portion (20) for holding a sample, and a component measurement device (14) to which the test strip (12) is attached and that optically measures a component contained in the sample. The component measurement device (14) emits measurement light traveling in a thickness direction of the main body portion (20). The main body portion (20) includes a light shielding portion (32) that shields the measurement light, and the light shielding portion (32) includes a measurement opening (34) through which a measurement position (44) of the measurement light is formed on a reaction product of the sample that reacts with a reagent.

Described herein is a method for mixing unequal amounts of two reagents to produce a detectable reaction in a microfluidic chip. In one example, there is a fluorescent microfluidic urinary albumin chip (UAL-Chip) that exploits the nonimmunological fluorescent assay. In this chip, we constructed a passive and continuous mixing module, in which the loading process requires only an inexpensive dropper, and the signal is stable over time, as discussed below. We applied a pressure-balancing strategy based on the immiscible oil coverage which highly improves the precision in controlling the mixing ratio of sample and dye. The UAL-Chip has achieved an estimated limit of detection (LOD) of 8.4 μg/ml using albumin standards, which is below the 30 μg albumin per ml urine level considered to be indicative of kidney damage.

A plasmon resonance system, instrument, cartridge, and methods for analysis of analytes is disclosed. A PR system is provided that may include a DMF-LSPR cartridge that may support both digital microfluidic (DMF) capability and localized surface plasmon resonance (LSPR) capability for analysis of analytes. In some examples, the DMF portion of the DMF-LSPR cartridge may include an electrode arrangement for performing droplet operations, whereas the LSPR portion of the DMF-LSPR cartridge may include an LSPR sensor. In other examples, the LSPR portion of the DMF-LSPR cartridge may include an in-line reference channel, wherein the in-line reference channel may be a fluid channel including at least one functionalized LSPR sensor (or sample spot) and at least one non-functionalized LSPR sensor (or reference spot). Additionally, methods of using the PR system for analysis of analytes are provided.

A method is provided for degradation-compensated evaluation of detection signals of a sensor arrangement operating on the principle of luminescence quenching, which arrangement has a luminophore that degrades over time, an excitation radiation source, and at least one optical sensor. The luminophore radiates, in accordance with a response characteristic of the sensor arrangement, in reaction to irradiation with a predefined modulated excitation radiation and as a function of the extent of an interaction of the luminophore with a quencher substance that quenches the luminescence of the luminophore. A response radiation is detected by the at least one optical sensor. The sensor arrangement outputs a detected intensity value representing an intensity of the response radiation and a detected phase value representing a phase difference of the response radiation with respect to the modulation of the excitation radiation. A predetermined calibration value correlation is identified in consideration of the reference response characteristic.

Embodiments provided herein relate to methods, compositions and systems for rapid determination of the bioavailability of a therapeutic biologic in a sample from a subject. In some such embodiments, the presence or absence of a therapeutic biologic in a sample can be determined using an optical sensor

The invention relates to a photonic sensor chip comprising a semiconductor substrate with a cavity extending from a back side through an entire depth of the semiconductor substrate, a photonic plane located on the front side of the semiconductor substrate. The chip includes a photonic particle sensor element with an active-surface element having an exposed active surface facing towards the back side of the semiconductor substrate, for capturing selected particles from at least one fluid or gas to which the active surface is exposable. The cavity provides access to the active surface from the back side. The photonic particle sensor element receives an optical input wave via the photonic plane, to expose captured particles on the active-surface element to interaction with the optical input wave and to provide a resulting optical output wave having a spectral component indicative of the interaction between the optical input wave and captured particles.

A sample of water is tested for silica and phosphate content in a single apparatus. In the test method, a first sample of the water is colorimetrically analyzed in a reaction chamber rusing a “molybdenum blue” test in which silica and phosphate in the sample are complexed with a first reagent. The phosphate complexes are then optically inactivated by a second reagent and the color of the silica complexes is intensified with a third reagent. From this, the silica content is calculated. A further sample is colorimetrically analyzed without using the second reagent, so that a combined silica and phosphate content of the further sample is obtained. A value of the silica content is subtracted from the value of the combined silica and phosphate content, resulting in a phosphate content for the sample. The silica content and the phosphate content of the sample are reportable.