The presently claimed invention applies to an immunoassay apparatus based on micro-lens imaging technique and related product. In a preferred embodiment, the immunoassay apparatus comprises a monochromatic light source module, an intelligent auto-scanning and imaging module, a temperature controlled transparent toughened glass platform, a central control module, and a touchscreen displaying module. By automatically performing scan in focus imaging on the micro-lenses immersing in antigen-antibody solution and analyzing the data of the image, the apparatus can monitor the refractive index change of a sample solution before and after antigen-antibody reaction, so as to determine the concentration of antigen or antibody in the solution without requiring any labeling, expensive enzymes, pre-immobilization/modification, and post-washing. It can detect ultra-micro amount of Ag/Ab (pg/mL) in very low sample volume solution (several L) within 2 minutes. It is of high accuracy and reliability. Moreover, the apparatus is simple and compact, can be portable for on-site immunoassay.

A guided mode resonance (GMR) sensor assembly and system are provided. The GMR sensor includes a waveguide structure configured for operation at or near one or more leaky modes, a receiver for input light from a source of light onto the waveguide structure to cause one or more leaky TE and TM resonant modes and a detector for changes in one or more of the phase, waveshape and/or magnitude of each of a TE resonance and a TM resonance to permit distinguishing between first and second physical states of said waveguide structure or its immediate environment.

The present invention relates to a sensor using a tilted fiber grating to detect physical manifestations occurring in a medium. Such physical manifestations induce measurable changes in the optical property of the tilted fiber grating. The sensor comprises a sensing surface which is to be exposed to the medium, an optical pathway and a tilted grating in the optical pathway. The grating is responsive to electromagnetic radiation propagating in the optical pathway to generate a response conveying information on the physical manifestation.

A device for determining a refractive index may be provided. The device including at least one waveguide having a core and a cladding surrounding the core, the cladding being at least partly removed in at least one first longitudinal portion and the core including at least one fiber Bragg grating in at least one second longitudinal portion. A method for determining a refractive index or a pressure change in a fluid may also provided. The method may include at least one waveguide having a core and a cladding surrounding the core, the cladding being at least partly removed in at least one longitudinal portion. A method for producing such a device may also be provided.

A diffractive biosensor for selective detection of biomolecules includes a substrate and a flat waveguide disposed on the substrate. The waveguide has an optical grating configured to couple incident light into the waveguide such that the light is guided through the waveguide to a detection region located behind an edge of the waveguide. The in-coupling efficiency and intensity of the light arriving in the detection region are dependent on a surface coverage of the optical grating with the biomolecules to be detected. The optical grating has receptors for the biomolecules periodically arranged on the waveguide. The light incident on the optical grating is collimated.

An optical fiber comprising a layer of coating composition disposed on the exterior of a glass fiber. The layer of coating composition comprises plasmonic nanocrystals dispersed in a porous polymer such as one or a plurality of polymers with intrinsic microporosity (PIMS). The layer of coating composition may be a composite comprising polymer and functionalized plasmonic nanocrystals. A method of making the coated optic fiber is also described. The coated optic fiber can be used to make a sensor and measure an analyte by measuring light transmission through the fiber.

A device for use in the detection of binding affinities, the device comprising a planar waveguide (2) arranged on a substrate (3), and further comprising an optical coupler (41) having a predetermined length for coupling coherent light (1) of a predetermined wavelength into the planar waveguide (2) such that a parallel beam of coherent light propagates through the planar waveguide (2) with an evanescent field (11) of the coherent light propagating along an outer surface (21) of the planar waveguide (2). The outer surface (21) of the planar waveguide (2) comprises binding sites thereon capable of binding target samples to the binding sites such that light of the evanescent field (11) is diffracted by target samples bound to the binding sites. The binding sites are arranged along a plurality of predetermined straight lines (7) running parallel to one another with a constant distance between adjacent straight lines.

The present invention is a system for determining and reporting results from a test including a stick having a collection area configured to collect an analyte; a reagent for application on the analyte to provide a post reaction analyte color; a visual scale having a plurality of hues and operatively associated with the post reaction analyte color; and, computer instructions having an image capture system for capturing a digital image of the visual scale and the post reaction analyte color, determining the contrast between hues of the visual color scale, assigning a range of color to each hue, assigning a blood glucose value to each range of color, determining the range of color containing the post reaction analyte color, retrieving the blood glucose value associated with the hues of the range containing the color of the post reaction analyte, displaying the blood glucose level on the remote computer device.

A system detects an analyte suspected of being present in a sample. The reader reads an optical tag on a substrate, which is configured to immobilize the tag on a substrate surface. The optical tag is bound to a probe and includes a plurality of pores that create an effective index of refraction. The plurality of pores and a thickness of the tag are selected for a reflectance property. The substrate is configured to contact a sample suspected of comprising an analyte. The probe is capable of binding specifically to the analyte. The reader is configured to expose the tag to light to generate a sample spectral signature that is a function of the effective index of refraction, the thickness of the optical tag, and whether the analyte is coupled to the probe. The sample spectral signature is compared to a reference to detect the analyte in the sample.

A surface refractive index acquisition system for characterization of a sample is provided. The system comprises a grating device configured to receive the sample, and first and second grating regions. First and second grating periods are selected to provide optical resonances for light respectively in first and second wavelength bands. A light source is configured to illuminate part of the first and second grating regions simultaneously. An imaging system is configured to image light from the grating device and comprises an optical element focusing light in a transverse direction and being invariant in an orthogonal transverse direction, the optical element being oriented such that the longitudinal direction of the grating device is oriented to coincide with the invariant direction of the optical element, and an imaging spectrometer comprising an entrance slit having a longitudinal direction oriented to coincide with the invariant direction of the optical element.