Methods, apparatuses, and systems associated with a sample testing device are provided.

A diffractometric sensing device for analyzing molecular interactions is described, the diffractometric sensing device comprising a transparent carrier medium, the carrier medium comprising a grating structure (42.1-42.5) with a plurality of consecutive surfaces or lines and a plurality of binding sites arranged thereon, the binding sites being configured to interact with one or more target molecules, wherein the grating structure is configured to diffract a portion of coherent light propagating in the carrier medium so as to produce a constructive interference signal at a light detector (4.1-4.4), the signal being dependent on molecular interactions at or in the vicinity of the binding sites. The invention offers more sensitivity, faster response, miniaturization, easy manufacturing and more applications compared to current diffractometric sensing devices.

Methods, apparatuses, and systems associated with a sample testing device are provided.

An optical sensing apparatus is provided comprising: an input interface for receiving input light into the optical sensing apparatus; an input waveguide and a reference waveguide, both arranged to receive input light from the input interface; a closed loop resonator, wherein the input waveguide is optically coupled to the closed loop resonator at an input point for introducing input light to the closed loop resonator; a sample region, adjacent the closed loop resonator, for receiving a sample such that evanescent coupling can occur between light in the closed loop resonator and the sample; a drop-port waveguide, optically coupled to the closed loop resonator at a drop point for receiving dropped light from the closed loop resonator; an output waveguide; and an output interface. The reference waveguide and the drop-port waveguide are arranged to direct interfering light through the output waveguide to produce an output signal at the output interface.

Disclosed herein are integrated photonics systems (3800) for biosensing including an interrogator photonic circuit (3802) and cartridge (3804) and methods using these systems. The cartridge (3804) comprises a sensor photonic integrated subcircuit. The cartridge (3804) is configured to receive a biological sample. The interrogator photonic circuit (3802) is optically coupled to the cartridge (3804) an comprises: (i) a light source (3806) configured to generate light; and (ii) one or more waveguides configured to carry the light, wherein the light is used to determine a characteristic of the biological sample in the cartridge (3804). A system can have an assembly of a plurality of modular photonic integrated subcircuits. Each subcircuit can be pre-fabricated and can be configured to transfer light to and receive light from another subcircuit based on the first functionality. An output port of a first subset of the subcircuits can be configured to be aligned with an input port of a second subset of the subcircuits. At least one subcircuit can be configured to be removed from the first integrated photonics assembly and connected to a second integrated photonics assembly having a second functionality. The first integrated photonics assembly can be different from the second integrated photonics assembly and the first functionality can be different from the second functionality.

The present invention relates to a humidity-sensing structural color emitting laminate and a structural color display device self-powered by triboelectricity including the same, and more specifically to a structural color display device self-powered by triboelectricity, which can directly sense humidity among human body signals and display the same in structural color immediately without a separate power source and without data processing, and a humidity-sensing structural color emitting laminate for implementing the same.

A sensing system for characterizing analytes of interest in a sample comprises a photonic integrated circuit with an integrated interferometer. The integrated interferometer is configured for spectroscopic operation. The integrated interferometer comprises at least a sensing arm and a reference arm, both the sensing arm and the reference arm having an exposable segment available for interaction with the sample, whereby the exposable segment of the reference arm has an optical path length which is smaller than twice the optical path length of the exposable segment of the sensing arm. The exposable section of the sensing arm is selective to the analyte of interest, whereas the exposable section of the reference arm is not selective to the analyte of interest.

A component or device is provided for the detection or the measurement in parallel of one or more specific types of biological or chemical target products. This component includes a group of nanotubes selected and/or functionalized to interact with the target product, around an optical waveguide. Thus, an optical coupling is produced between the optical waveguide and one or more optical characteristics of these nanotubes, the modifications of which are evaluated in the presence of the target product. In addition, a method is provided for manufacturing and preparing such a component or device, and a detection method using them, as well as a post-manufacture preparation method comprising a specific functionalization for different target products starting from the same type of pluripotent generic component. Also provided is a family of PFO-based functionalization polymers.

An optical detection type chemical sensor includes a light source, a detection element and a photodetector. The detection element is constituted of a laminate in which a multilayer film including a chemical detection layer, an optical interference layer, and a half mirror layer is formed on a transparent substrate. At least one of the layers includes a magnetic material. Light from the light source is applied to the detection element under the condition that the light enters inside of the detection element from the rear surface of the transparent substrate on which the laminate is not formed and multiple reflection occurring in the laminate intensifies the magneto-optical effect. A subject is detected by using the photodetector to detect a magneto-optical signal indicating a change in reflected light from the laminate resulting from a change in an optical property resulting from a reaction in the chemical detection layer.

Provided herein are compositions, systems, and methods for performing a biological or chemical analysis of a sample using encoded functionalized optical tags. These optical tags can generate a unique spectral signature correlated with the identity of a probe bound to the optical tag, and a state of the interaction of the probe with an analyte. Also provided herein are methods of generating encoded functionalized optical tags.