A point of use analyte detection and quantification system for agricultural applications is provided. Related methods are also provided.

This disclosure provides methods and devices for the label-free detection of target molecules of interest. The principles of the disclosure are particularly applicable to the detection of biological molecules (e.g., DNA, RNA, and protein) using standard SiO2-based microarray technology.

A photonic integrated circuit for an interferometric sensor includes a first waveguide called sensitive arm wherein a first portion of the light radiation is propagated, the sensitive arm being exposed to a first ambient medium and to at least one compound to be detected inducing a modification of the local refractive index perceived by the evanescent part of the electromagnetic field of the first portion of the light radiation, and a second waveguide called reference arm wherein a second portion of the light radiation is propagated, an encapsulation layer encapsulating the reference arm, the encapsulation layer being impermeable to the compound or compounds to be detected, so that the reference arm is exposed only to a second ambient medium, substantially of the same nature as the first ambient medium and without the compound to be detected and interferometric sensor comprising a photonic integrated circuit according to the invention.

A colorimetric sensor for detecting an analyte of interest in a fluid sample includes a lamellar photonic material having alternating layers of a first polymer layer and a second polymer layer. Each first polymer layer can be a molecularly imprinted polymer defining a cavity shaped to receive an analyte of interest. The photonic material is configured such that, when an analyte contacts the photonic material and becomes disposed within a cavity of the molecularly imprinted polymer, a refractive property of the photonic material changes, causing a detectable color change in the sensor.

This disclosure provides methods and devices for the label-free detection of target molecules of interest. The principles of the disclosure are particularly applicable to the detection of biological molecules (e.g., DNA, RNA, and protein) using standard SiO.sub.2-based microarray technology.

Devices and methods of providing a high-performance optical sensor disclose a sensor comprised of a porous material designed to have a multilayer rib-type or multilayer pillar-type waveguide geometry. The resulting porous nanomaterial multilayer-rib or multilayer-pillar waveguide design is optically capable of achieving ˜100% confinement factor while maintaining small mode area and single-mode character. Fabrication of the device is enabled by an inverse processing technique, wherein silicon wafers are first patterned and etched through well-established techniques, which allows porous nanomaterial synthesis (i.e., porous silicon anodization) either at the wafer-scale or at the chip-scale after wafer dicing. While ˜100% is an optimal target, typical devices per presently disclosed subject matter may operate with ˜98-99+%, while allowing for some design adjustments to be made if necessary, and still maintaining high sensitivity. i.e., >85-90% confinement suitable in some applications. In those instances, a primary benefit would still be use of the presently disclosed fabrication technology.

A point of use analyte detection and quantification system for chemical applications is provided. Related methods are also provided.

An optical waveguide interferometer cartridge system and related methods are provided. The optical waveguide interferometer cartridge system includes a cartridge housing comprising an interferometric chip and a flow cell wafer as well as an alignment means for aligning the cartridge system within the interferometric system.

A point of use analyte detection and quantification system for agricultural applications is provided. Related methods are also provided.

A point of use analyte detection and quantification system for aquatic applications is provided. Related methods are also provided.