Disclosed are a sample analysis apparatus and method which include: obtaining a first light signal by irradiating a first test sample from blood and a first-channel reagent to differentiate neutrophils, eosinophils, lymphocytes, and monocytes; obtaining a second light signal from a second test sample from the blood and a second-channel reagent; counting the nucleated red blood cells and lymphocytes based on the second light signal; determining accuracy of the lymphocyte result from the first test sample; and if inaccurate, correcting the lymphocyte result based on the lymphocyte result of the second test sample.

The invention relates to a testing system and related methods for detecting peritonitis or infection in peritoneal dialysate removed from a patient. The testing system can include a fluid sensor apparatus in a fluid line of a peritoneal dialysis cycler through which spent peritoneal dialysate can be pumped. The fluid sensor apparatus can detect one or more markers associated with peritonitis or infection.

A waveguide sensor system is provided. The system includes a light source and a waveguide formed from a light transmitting material. Light from the light source enters the waveguide at an input area and travels within the waveguide by total internal reflection to an analyte area and light to be analyzed travels within the waveguide from the analyte area by total internal reflection to an output area. An optical sensor is coupled to the output area and is configured to interact with the light to be analyzed. The system includes a plurality of pores located along the outer surface within the analyte area and formed in the light transmitting material of the waveguide, and the pores are configured to enhance light interaction with the analyte within the analyte area. The pores and analyte area may be protected and/or enhanced with a hydrophobic layer overlaying the pores.

Bistable devices are constructed using a polynucleotide platform for sensing molecular events such as binding or conformational changes of target molecules. Uses include measurement of target concentration, measuring the effect of environmental condition (such as heat, light, or pH) on the target, or screening a library for molecules that bind the target or modulate its biological function. Devices comprise three regions: a top lid, bottom lid, and flexible linker or hinge between them. A device has an open configuration in which the top and bottom lid are separated, and a closed configuration they are bound close together. Binding domains or variations of the target molecule are fixed to a device so that when the molecular event occurs, the device switches from open to closed, or vice versa, which generates a signal. Optimal device design is determined by the signal modality (optical or electronic) used to measure closure of surface-immobilized devices.

Modules, devices, systems and methods for measuring or detecting cysteine and/or methionine metabolite levels in a sample from a subject are disclosed. Various embodiments of the present invention concern modules, devices, systems and methods for prognosing or diagnosing cancer, for example, prostate, colon, ovarian or breast cancer; predicting the risk or probability of cancer recurrence; and/or for predicting, detecting and/or monitoring cystinuria or cystine stone disease.

The invention relates to a detector system suitable for detection of an aromatic hydrocarbon, comprising an organic polymeric sensor material that is permeable to the aromatic hydrocarbon, the sensor material comprising a molecular probe selected from the group of methanatoboron moieties. Further, the invention relates to the use of a detector system according to the invention for the detection of an aromatic hydrocarbon, preferably an aromatic hydrocarbon selected from the group of benzene, toluene and xylene.

Optics collection and detection systems are provided for measuring optical signals from an array of optical sources over time. Methods of using the optics collection and detection systems are also described.

The disclosed technology brings histopathology into the operating theatre, to enable real-time intra-operative digital pathology. The disclosed technology utilizes confocal imaging devices image, in the operating theatre, “optical slices” of fresh tissue—without the need to physically slice and otherwise process the resected tissue as required by frozen section analysis (FSA). The disclosed technology, in certain embodiments, includes a simple, operating-table-side digital histology scanner, with the capability of rapidly scanning all outer margins of a tissue sample (e.g., resection lump, removed tissue mass). Using point-scanning microscopy technology, the disclosed technology, in certain embodiments, precisely scans a thin “optical section” of the resected tissue, and sends the digital image to a pathologist rather than the real tissue, thereby providing the pathologist with the opportunity to analyze the tissue intra-operatively. Thus, the disclosed technology provides digital images with similar information content as FSA, but faster and without destroying the tissue sample itself.

Facemasks with an integrated vims detection system are described. The virus detection system is embedded in or on a acemask worn by an individual susceptible to a viral infection. The individual wears a facemask for protective purposes during work or leisure. If the individual develops a viral infection and begins discharging viral particles from mouth and/or nose, the vims detection system embedded in the facemask retains the virus particles. The virus particles are detected in an immunoassay. The virus particles in the virus detection system embedded in the facemask are detected by avian antibodies. The virus detection system in the facemask is configured to detect one or more viruses, for example, SARS-CoV-2.

One variation of a pathogen detection system includes an air sampler and a cartridge. The air sampler includes: a housing defining an inlet and an outlet; a tunnel arranged within the housing and extending between the inlet and the outlet; a charge electrode arranged within the tunnel proximal the inlet; a cartridge receptacle arranged proximal the outlet and comprising a cartridge terminal; and a power supply configured to drive a voltage between the charge electrode and the cartridge terminal. The cartridge includes: a substrate; a collector plate arranged on the substrate and configured to collect charged bioaerosols moving through the tunnel; and a connector configured to transiently engage the cartridge receptacle to locate the substrate and the collector plate within the tunnel and electrically couple the collector plate to the cartridge terminal.