The present invention generally relates to continuous methods quantifying a target analyte concentration in a process solution. These methods are continuous automated titration methods that use titration chemistries to measure the target analyte concentration in the process solution. The method steps provide for efficient and robust automated titration methods for a variety of target analytes.

The present invention generally relates to continuous methods quantifying a target analyte concentration in a process solution. These methods are continuous automated titration methods that use titration chemistries to measure the target analyte concentration in the process solution. The method steps provide for efficient and robust automated titration methods for a variety of target analytes.

Color quantification of chemical test pads and titration of analytes can be performed under different lighting conditions. In one embodiment, the lighting condition is estimated under which a digital image is captured and utilized to select a set of reference colors from which the quantified color is compared to determine the titration. In another embodiment, a plurality of comparisons are made with different lighting conditions with the result having the highest confidence level being selected to determine the titration.

Color quantification of chemical test pads and titration of analytes can be performed under different lighting conditions. In one embodiment, the lighting condition is estimated under which a digital image is captured and utilized to select a set of reference colors from which the quantified color is compared to determine the titration. In another embodiment, a plurality of comparisons are made with different lighting conditions with the result having the highest confidence level being selected to determine the titration.

Systems for quantifying a target analyte concentration in a process solution are provided and can be used, for example, in methods for quantifying a target analyte concentration. These systems and methods include continuous automated titration methods that use titration chemistries to measure the target analyte concentration in the process solution. The method steps provide for efficient and robust automated titration methods for a variety of target analytes and can include methods that provide for methods that provide a dynamic range for measurement of target analyte concentrations.

A device and method for testing for the presence of liquid in a cannula of a medical instrument is described. The device includes a flexible guide member having a first end, a second end and a length extending from the first end to the second end, an elongated member arranged within the flexible guide member, and an absorbent material attached to one of the elongated member. The flexible guide member is inserted into the cannula, the flexible guide member is manipulated to cause the absorbent material to move through the cannula. The absorbent material is analyzed for the presence of liquid.

A device and method for testing for the presence of liquid in a cannula of a medical instrument is described. The device includes a flexible guide member having a first end, a second end and a length extending from the first end to the second end, an elongated member arranged within the flexible guide member, and an absorbent material attached to one of the elongated member. The flexible guide member is inserted into the cannula, the flexible guide member is manipulated to cause the absorbent material to move through the cannula. The absorbent material is analyzed for the presence of liquid.

A titration system is disclosed for determining content of an analyte in a sample. The titration system comprises: a controller; a reaction vessel; a titration vessel and an indicator vessel in fluid communication with the reaction vessel; a spectroscopy unit; a sensor for outputting a signal to the controller based on a force exerted by the reaction vessel on the sensor. The controller executes a stored program to: (i) perform titration by delivering to the reaction vessel a first mass of a first fluid comprising the sample, a second mass of a second fluid comprising indicator, and a third mass of a third fluid comprising titrant; (ii) detect color change in the mixture in the reaction vessel based on a signal from the spectroscopy unit and stop titration; and (iii) calculate content of the analyte in the sample based on the first mass, the second mass, and the third mass.

A titration system is disclosed for determining content of an analyte in a sample. The titration system comprises: a controller; a reaction vessel; a titration vessel and an indicator vessel in fluid communication with the reaction vessel; a spectroscopy unit; a sensor for outputting a signal to the controller based on a force exerted by the reaction vessel on the sensor. The controller executes a stored program to: (i) perform titration by delivering to the reaction vessel a first mass of a first fluid comprising the sample, a second mass of a second fluid comprising indicator, and a third mass of a third fluid comprising titrant; (ii) detect color change in the mixture in the reaction vessel based on a signal from the spectroscopy unit and stop titration; and (iii) calculate content of the analyte in the sample based on the first mass, the second mass, and the third mass.

A reagent test paddle includes a contamination detection medium, a reference color bar, at least one chemical test medium, and a unique identifier. The contamination detection medium includes a reagent that changes color in the presence or when exposed to a hostile or inhospitable environment. Each chemical test medium includes a regent that is responsive to a respective analyte in a biological sample. The reference color bar includes reference color samples of different colors. The unique identifier, like a serial number, identifies the particular paddle and its chemical test medium so it can be uniquely and anonymously associated with a user. A method includes capturing and interpreting digital images of a biologically unexposed and subsequently exposed reagent test paddle at various delay times within an automatically calibrated environment; locating the paddle in a plurality of digital images, extracting the reference color bar and locating the contamination detection medium and chemical test medium in each digital image. Color changes of the chemical test medium and contamination medium are detected at various delay times after sample exposure. To determine validity of test results, the method further compares the detected colors of the contamination detection medium with predetermined colors expected for no contamination and contamination.