The present invention concerns a device for analyzing biological parameters from a sample (6) comprising (i) first transferring means (5, 20, 25), (ii) first preparing means (7), (iii) means for measuring cellular components (8), (iv) second preparing means (10, 11, 22, 23, 24) capable of carrying out, on a sample from the first preparing means (7), at least one dilution with an assay reagent (R3) comprising particles functionalized at the surface with at least one ligand specific to at least one analyte of interest, (v) immunodetection measurement means (30, 31) capable of assaying at least one analyte of interest by measuring the aggregation of functionalized particles, said device further comprising (i) second transferring means (4, 21, 22, 26) at least partially separate from the first transferring means (5, 20, 25) and (ii) means for applying a magnetic field (28) capable of causing, by magnetic interaction, an acceleration of the aggregation of said functionalized particles, which comprise magnetic colloidal particles. The invention also concerns a method implemented in said device.

A method for determining the amount of a specific analyte by photometric assays, wherein the specific analyte in a sample reacts with an analyte specific reaction partner in a reaction mixture. At least two calibration curves are generated, the first calibration curve recorded at a first wavelength is optimized for low concentrations of the specific analyte thereby maximizing the lower detection limit and, the second calibration curve recorded at a second wavelength is optimized for high concentrations of the specific analyte thereby maximizing the upper detection limit. The optimized lower detection limit and the optimized upper detection limit results in an extended dynamic range.

What is disclosed is a method for creating a database for determining a virtual reference value for a light transmission aggregometry measurement, comprising the following steps: a. providing platelet-rich plasma PRP (17) of a reference blood sample; b. performing a light transmission measurement with a first light wavelength and a second light wavelength (14), different from the first, on the PRP (17) of the reference blood sample; c. providing platelet-poor plasma PPP of the reference blood sample; d. performing a light transmission measurement on the PPP in order to determine a PPP reference value; e. assigning the measurement result of step d to the measurement results of step b in a database; f. repeating steps a to e for a plurality of reference blood samples. The database obtained using this method makes it possible to determine a virtual reference value that is an excellent estimate of the PPP reference value. Once the database has been created, it is possible to determine virtual reference values of blood samples to be examined and perform LTA measurements using the virtual reference values, without the need to obtain PPP from the blood samples to be examined.

An object of the present invention is to provide a novel preservative solution for a heme protein and a method for stabilizing a heme protein, which are effective against denaturation or degradation of a heme protein, and the present invention specifically relates to a preservative solution for a heme protein comprising a disulfonic acid or a salt thereof, and a method for stabilizing a heme protein, which involves bringing a disulfonic acid or a salt thereof into coexistence in a sample comprising a heme protein.

If an air bubble is entrained when a reagent is added to a sample, disturbance caused by this air bubble may prevent accurate optical measurement, thereby reducing accuracy for measuring blood clotting ability. The position to dispense the reagent depends on accuracy of stopping a reagent dispensing mechanism and dimensional errors of individual detectors, and thus conventional reagent discharging method may entrain an air bubble because a distance between a nozzle for dispensing the reagent and an inner wall of a reaction vessel is not constant and conditions for dispensing the reagent to the sample vary. In the present invention, an automatic analyzer with a nozzle for sucking and discharging the reagent for blood clotting reaction is provided with a dispensing mechanism that keeps a constant position for the nozzle to discharge the reagent by pressing the nozzle against the inner wall of the reaction vessel within the elastic range.

Methods, systems, and computer readable media for determining physical properties of a specimen in a portable point of care device are disclosed. According to one aspect, a method includes placing a specimen onto an active surface that includes a plurality of microposts extending outwards from a substrate, wherein each micropost includes a proximal end attached to the substrate and a distal end opposite the proximal end and generating an actuation force in proximity to the micropost array that compels at least some of the microposts to exhibit motion. The method further includes detecting light that is emitted by an illumination source and interacts with the active surface while the at least some microposts exhibit motion in response to the actuation force, measuring data that represents the detected light interacting with the active surface, and determining at least one physical property of the specimen based on the measured data.

Disclosed is a blood sample determination method including: preparing a mixed plasma by mixing a subject plasma and a normal plasma; emitting light to a measurement specimen obtained by mixing the mixed plasma and a clotting time measuring reagent, to obtain optical information regarding an amount of light from the measurement specimen; and determining whether the subject plasma is suspected to be a coagulation-factor-deficient plasma, on the basis of optical information obtained from one measurement specimen.

A sample analyzer includes: a preparation unit configured to mix a sample with a reagent to prepare a measurement specimen; a measurement unit configured to irradiate the measurement specimen with light to acquire optical time series data; and a controller configured to divide the time series data acquired by the measurement unit into data segments, determine first regression lines respectively of the data segments, select the first regression line with the highest matching degree with the time series data, set as an analysis target region a region of the time series data matching with the selected first regression line among the time series data acquired by the measurement unit, determine a second regression line using the time series data included in the set analysis target region, and perform an analysis using the second regression line.

Disclosed is a sample analyzer configured to analyze a concentration of a target material contained in a sample based on a value representing a slope of a regression line which is based on data values included in an interval from a start point to an endpoint. The start point is detected by a predetermined method and the endpoint is detected by a predetermined method.

A fluid test cartridge, a fluid test apparatus, and a method for controlling the same. The fluid test apparatus includes a housing, and a fluid test cartridge that is accommodated in the housing. The fluid test cartridge includes at least one chamber in which a fluid sample to be tested and a drying reagent can be accommodated. The fluid test apparatus includes a light emitter configured to emit light to the at least one chamber, a light sensor, and a processor configured to detect a concentration of a first material in the fluid sample. The drying reagent includes a non-metallic particle bound to a second material that specifically binds to the first material. Tests can thus be carried out over a wider range of wavelengths, and testing errors can be reduced.