The present disclosure relates to an in-line compact measuring device, for example for optical measurements, comprising a housing having a process connection intended to be connected to a process vessel connection complementary to the process connection; at least one sensor assembly arranged in the housing; and a measuring circuit that is connected to the sensor assembly and is arranged in the housing. The in-line compact measuring device has at least one fluid line in thermally conductive contact with at least one housing wall of the housing, which fluid line can be connected to a cooling fluid supply arranged outside the housing.

A device for analysing a product to be analysed which is located in a product space having a probe body arranged in a probe housing and having a peripheral wall, and at least one radiation source and at least one optical receiver. At least one measurement window in the probe body has an entry region and an exit region for measurement radiation. An evaluation unit is also provided. The probe body can be brought into a measurement position, in which at least one part of the probe body in which the measurement window is located penetrates through an opening of the probe housing into the product space for the analysis. In addition, the probe body can be brought into a retracted position, in which the probe body is still located at least partially in the region of the opening of the probe housing and thus covers the opening.

A sensor system for sensing contaminants within a fluid stream of a fluid system includes a sensor body and an arm extending from the sensor body to a distal end of the arm, a laser light source configured to direct a laser beam outwardly from an outlet of the sensor body, and a light sensor. A fiber optic light guide is disposed in the sensor body and extends from the light sensor to an inlet of the sensor body for directing light to the light sensor. A beam dump is positioned at the distal end opposite the laser light source to absorb at least a portion of the laser beam directed towards the distal end. A blocking member of the arm is disposed intermediate between the sensor body and the distal end and is configured to partially restrict a field of intake of light at the inlet.

A device for determining the composition of a mixture of fluids that flow along a pipe includes: a radiation source for illuminating the mixture with radiation; a detector for detecting radiation that has been attenuated by the mixture; and a device for monitoring the flow rate of fluid along the pipe and outputting a signal indicative of the flow rate. The device for determining further includes a device for adjusting the intensity of radiation emitting by the radiation source in response to the signal indicative of the flow rate so that the intensity of the radiation source is reduced if the flow rate reduces.

A device for measuring an ionic concentration of an ionic compound in a porous medium solution contained in a porous medium. The device includes a sensing portion, a light source, and a light sensor. The sensing portion is miniaturized and includes a permeable material body defining a measuring cavity therein and is insertable in the porous medium to allow the porous medium solution to diffuse through the permeable material body. The light source illuminates the porous medium solution contained inside the measuring cavity. The light sensor detects a resulting light emanating from the porous medium solution, the resulting light having at least one spectral characteristic indicative of the ionic concentration of the ionic compound in the porous medium solution. There is also provided a method for measuring in situ an ionic concentration of an ionic compound in a porous medium solution contained in a porous medium.

A device for determining the composition of a mixture of fluids that flow along a pipe includes: a radiation source for illuminating the mixture with radiation; a detector for detecting radiation that has been attenuated by the mixture; and a device for monitoring the flow rate of fluid along the pipe and outputting a signal indicative of the flow rate. The device for determining further includes a device for adjusting the intensity of radiation emitting by the radiation source in response to the signal indicative of the flow rate so that the intensity of the radiation source is reduced if the flow rate reduces.

The present disclosure provides systems and methods that allow users to quickly determine titer and remove hold steps by determining a first concentration using slope spectroscopy, depleting the fluid of the expressed protein by selective adsorption, and determining a second concentration using slope spectroscopy. Further, the systems and methods of the present disclosure allows the user to forgo the use of a bioanalyzer or HPLC.

An in-situ photocatalysis monitoring system based on surface-enhanced Raman Scattering (SERS) spectroscopy. The monitoring system may include a Raman excitation light source, a laser coupling lens, a narrow band filter, a total reflection mirror, a dichroic mirror, a focusing coupling lens, a SERS optical fiber probe, a liquid phase photocatalysis reactor, a photocatalytic light source, a Raman collection lens, and a spectrometer. A first furcation part and a second furcation part each extend from one end of a common detection part of the SERS optical fiber probe; an extending end of the first furcation part is coupled with the focusing coupling lens; an extending end of the second furcation part is coupled with the photocatalytic light source; and the other end of the common detection part is arranged inside the liquid phase photocatalysis reactor. Raman excitation light and photocatalytic light may be transmitted on a common channel.

A device for monitoring a bioreactor is configured for in-situ analysis, e.g., by NIR, without the need for withdrawing a sample into a sample cell or into an ex-situ arrangement. The device can be inserted into a port of the bioreactor and provides a sample detection region defined by an optical element such as a lens and a photodetector. The electrical signal obtained from a photodetector that is part of the device can be directed to an analyzer via a detachable electrical connection.

The present disclosure discloses an optochemical sensor for determining a measurand correlating with a concentration of an analyte in a measuring fluid, comprising: a housing having an immersion region configured for immersing in the measuring fluid; a removable cap having a sensor spot, the removable cap removably arranged at the immersion region of the housing, wherein the sensor spot is disposed on a circumferential face; a radiation source disposed in the housing for radiating excitation radiation into the removable cap, wherein a deflection module is disposed in the removable cap as to deflect excitation radiation radiated into the removable cap; a radiation receiver disposed in the housing for receiving received radiation emitted by the sensor spot; and a sensor circuit disposed in the housing and configured to control the radiation source, receive signals of the radiation receiver, and generate output signals based on the signals of the radiation receiver.