This invention prevents measurement error from becoming large in thermoelectric conversion coefficient evaluation and enhances evaluation efficiency. This invention is a physical property evaluation device for evaluating the physical properties of a plurality of solid materials formed on a substrate. The physical property evaluation device comprises an electromotive force measurement means that forms closed circuits including the individual solid materials and measures the electromotive forces occurring at the two ends of each of the solid materials, a means for producing heat flow within the individual solid materials, an external magnetic field generation means for generating a uniform magnetic field having a given intensity and direction in the vicinity of the individual solid materials, and an automation means for evaluating the physical properties of the individual solid materials using the electromotive force measurement means, heat flow production means, and external magnetic field generation means.

Automated isothermal titration micro calorimetry (ITC) system comprising a micro calorimeter with a sample cell and a reference cell, the sample cell is accessible via a sample cell stem and the reference cell is accessible via a reference cell stem. The system further comprises an automatic pipette assembly comprising a syringe with a titration needle arranged to be inserted into the sample cell for supplying titrant, the pipette assembly comprises an activator for driving a plunger in the syringe, a pipette translation unit supporting the pipette assembly and being arranged to place pipette in position for titration, washing and filling operations, a wash station for the titrant needle, and a cell preparation unit arranged to perform operations for replacing the sample liquid in the sample cell when the pipette is placed in another position than the position for titration.

The present disclosure provides devices and methods for diagnosing, monitoring the disease progression of, and/or evaluating the risk for developing a disease by detecting thermostable variants of proteins and/or metabolites in biological samples using differential scanning calorimetry. Also disclosed herein are methods for monitoring the efficacy of a particular therapeutic regimen in patients in need thereof.

Automated isothermal titration micro calorimetry (ITC) system comprising a micro calorimeter with a sample cell and a reference cell, the sample cell is accessible via a sample cell stem and the reference cell is accessible via a reference cell stem. The system further comprises an automatic pipette assembly comprising a syringe with a titration needle arranged to be inserted into the sample cell for supplying titrant, the pipette assembly comprises an activator for driving a plunger in the syringe, a pipette translation unit supporting the pipette assembly and being arranged to place pipette in position for titration, washing and filling operations, a wash station for the titrant needle, and a cell preparation unit arranged to perform operations for replacing the sample liquid in the sample cell when the pipette is placed in another position than the position for titration.

Certain embodiments of the invention are directed to a photothermal immunoassay employing a thermometer or colorimetric detection method for sensitive quantitative readout based on the photothermal effect provided by a detection reagent.

Automated isothermal titration micro calorimetry (ITC) system comprising a micro calorimeter with a sample cell and a reference cell, the sample cell is accessible via a sample cell stem and the reference cell is accessible via a reference cell stem. The system further comprises an automatic pipette assembly comprising a syringe with a titration needle arranged to be inserted into the sample cell for supplying titrant, the pipette assembly comprises an activator for driving a plunger in the syringe, a pipette translation unit supporting the pipette assembly and being arranged to place pipette in position for titration, washing and filling operations, a wash station for the titrant needle, and a cell preparation unit arranged to perform operations for replacing the sample liquid in the sample cell when the pipette is placed in another position than the position for titration.

A sensing and analysis system on a chip for sensing and analyzing chemical or biological analytes includes a chromatography column having an inlet and an outlet formed on the chip for temporal separation of components of analytes and at least one whispering gallery mode (WGM) optical resonator for sensing of the components. The chromatography column is formed on a first wafer layer. Each WGM optical resonator includes a hollow sealed enclosure formed at or over the inlet or the outlet of or elsewhere along the chromatography column such that a gas flowing through the chromatography column fills the hollow sealed enclosure. Each WGM optical resonator further includes an optical waveguide aligned with the sealed hollow enclosure for evanescent wave light coupling.

The present disclosure relates generally to thermal analyses having direct application of thermal energy to a sample.

An apparatus is provided for sensing an analyte in a fluid. The apparatus includes a fluid collecting device configured to collect the fluid containing the analyte; a fluid input in fluid communication with the fluid collecting device configured to input the fluid containing the analyte into the fluid collecting device, an analyte interactant in fluid communication with the fluid collecting device, wherein the analyte interactant, when contacted by the analyte, reacts to cause a first change in thermal energy within the fluid collecting device; a modulator that causes a second change in thermal energy; a thermal sensing device comprising at least one pyroelectric device thermally coupled to the fluid collecting device to generate a first signal in response to at least one of the first change in thermal energy and the second change in thermal energy; a control device operatively coupled to the thermal sensing device and the modulator that generates a second signal, wherein the second signal comprises information useful in characterizing the analyte. A related method also is disclosed.

A system and method for estimating an adsorption equilibria for one or more gases from pure component adsorption isotherms includes providing one or more processors, a memory communicably coupled to the one or more processors and an output device communicably coupled to the one or more processors, calculating an adsorption of each gas on a constant monolayer adsorption surface is calculated using the one or more processors and the generalized Langmuir isotherm equations (24)-(26) or equation (27), providing the adsorption of each gas to the output device, and developing a chemical process or product is developed using the adsorption of each gas.