A formulation and method for delivery of bioactive substances when applied to, or within, the skin or other exterior region of a mammal. for example, a patient, includes a vasoactive agent; an osmolyte; and an active ingredient. The formulation is sufficiently hygroscopic so as to create a condition of hypertonicity when absorbed by the skin. When the formulation is applied to the skin, the vasoactive agent can be delivered to the dermis so as to contact the vasculature of a patient.

The present invention relates to an improved non-invasive transdermal medical patch. The medical patch is designed to attach to an ailing area of a body of a user for relieving chronic aches and pains. The medical patch comes in a variety of shapes and sizes, and is a non-invasive medical patch. The medical patch features a central bandage area infused with active charcoal, along with a recessed area that can receive ointments such as opioid medications. The patch uses a combination of the natural ingredient of activated charcoal and the medicated ointment for providing quick and easy relief from pain. The activated charcoal can be dried or lyophilized and can be moistened with water and then applied to an ailing body area of the user.

A skin patch that is adherable to human skin over a blemish on the skin has an outer layer that forms a physical barrier over the blemish when applied thereto and a hydrocolloid layer attached to the outer layer that contacts the blemish when applied thereto. A thermochromic material is on the skin patch and/or waterproof packaging encapsulating the skin patch. The thermochromic material indicates the skin patch is at a predetermined temperature.

A dressing for applying to the skin is characterized in that the adhesive mass is applied discontinuously in a strip or wave and contains an active substance.

Embodiments of the disclosure may include a medical device for releasing a medicament. The device may include a multi-layer patch. The patch may include a base layer configured to secure the patch to a body of a user and a medicament array located adjacent the base layer. The array may include a plurality of wells configured to release a quantity of medicament from the array to the body of the user. The device may also include a cover layer located on a side of the medicament array opposite the base layer and a pump operably coupled to the patch and configured to deliver a quantity of fluid to the patch.

A medical dressing comprising an absorbent adhesive layer having a pharmaceutically active agent incorporated, the non-skin-facing surface being provided with a backing layer and the skin facing surface being interrupted by a pattern of cavities. The cavities provide a storage room and distribution centre for wound exudates enabling the dressing to be applied to fast exuding wounds and at the same time allows for an increased initial release of the pharmaceutically active agent.

Provided is an adhesive sheet for affixation to the body which is excellent in enhancement and persistence of the blood circulation promoting action, has high affixability and conformability as a sheet, and is easily and widely applicable to the body in any use situation. That is, the present invention relates to an adhesive sheet for affixation to the body housed in a container, containing the following components (A) and (B): (A) bubbles containing carbon dioxide gas in a bubble fraction of 10% or more and 40% or less, and (B) water, wherein the total area occupied by bubbles having an imaginary diameter of 5 mm or more is 10% or less, in 100% of the surface area of the adhesive sheet for affixation to the body, a content of carbon dioxide gas in the total amount of the adhesive sheet for affixation to the body is from 100 to 20,000 ppm, and the adhesive sheet for affixation to the body is sealed in a low gas-permeable container.

Single layer and multi-layer anti-microbial wound care fabrics, gloves, sleeves, anklets, socks, finger cots, masks, and similar wound care articles are disclosed.

Transdermal therapeutic systems are described which have at least one electronic component, as well as methods for producing this type of transdermal therapeutic systems.

The present invention relates to a packaged probiotic composition which is useful for treating or preventing bacterial colonisation in wounds and tissue. A characteristic feature of the invention is that the probiotic composition contains a probiotic microorganism which is in direct contact with water during storage of the probiotic composition. The invention furthermore pertains to methods of using and producing the probiotic composition.