A formulation and method for delivery of bioactive substances when applied to, or within, the skin or other exterior region of a mammal. for example, a patient, includes a vasoactive agent; an osmolyte; and an active ingredient. The formulation is sufficiently hygroscopic so as to create a condition of hypertonicity when absorbed by the skin. When the formulation is applied to the skin, the vasoactive agent can be delivered to the dermis so as to contact the vasculature of a patient.

A wound dressing including a porous biosynthetic polymer film comprising a poly(lactide-co-caprolactone) (PLC) copolymer or other suitable polymer matrix, and a local analgesic loaded therein, to provide pain relief over an extended period of time (e.g., for 5-7 days), e.g., for healing of a partial thickness dermal injury. The PLC copolymer may have a particular lactide/caprolactone molar ratio (e.g., from 2:1 to 9:1) to ensure slow, sustained release of the bupivacaine or other analgesic. The dressing may provide a water vapor transmission rate from 1000 g/m.sup.2.Math.day to 3000 g/m.sup.2.Math.day to facilitate fast healing and regrowth of new epithelial tissue beneath the dressing. The dressing is configured to remain positioned over the dermal injury, providing wound protection for about 14 days, after which is simply debrides away, falls off, or is easily and painlessly removed, once new epithelial tissue regrows.

A skin patch that is adherable to human skin over a blemish on the skin has an outer layer that forms a physical barrier over the blemish when applied thereto and a hydrocolloid layer attached to the outer layer that contacts the blemish when applied thereto. A thermochromic material is on the skin patch and/or waterproof packaging encapsulating the skin patch. The thermochromic material indicates the skin patch is at a predetermined temperature.

The present disclosure describes a dermal patch including at least a support layer and a medicament depot including a medicament. The dermal patch is configured to support, protect, and/or medicate a wound during a healing process.

A wound dressing including a porous biosynthetic polymer film comprising a poly(lactide-co-caprolactone) (PLC) copolymer or other suitable polymer matrix, and a local analgesic loaded therein, to provide pain relief over an extended period of time (e.g., for 5-7 days), e.g., for healing of a partial thickness dermal injury. The PLC copolymer may have a particular lactide/caprolactone molar ratio (e.g., from 2:1 to 9:1) to ensure slow, sustained release of the bupivacaine or other analgesic. The dressing may provide a water vapor transmission rate from 1000 g/m.sup.2.Math.day to 3000 g/m.sup.2.Math.day to facilitate fast healing and regrowth of new epithelial tissue beneath the dressing. The dressing is configured to remain positioned over the dermal injury, providing wound protection for about 14 days, after which is simply debrides away, falls off, or is easily and painlessly removed, once new epithelial tissue regrows.

The present disclosure describes a dermal patch including at least a support layer and a medicament depot including a medicament. The dermal patch is configured to support, protect, and/or medicate a wound during a healing process.

A skin patch that is adherable to human skin over a blemish on the skin has an outer layer that forms a physical barrier over the blemish when applied thereto and a hydrocolloid layer attached to the outer layer that contacts the blemish when applied thereto. A thermochromic material is on the skin patch and/or waterproof packaging encapsulating the skin patch. The thermochromic material indicates the skin patch is at a predetermined temperature.

A therapeutic device used for monitoring a wound includes an external layer impermeable to gas and moisture with a periphery that adheres to a user's skin about the wound and an internal layer with a periphery adhered to the external layer creating a gaseous reservoir between the external and internal layers. The internal layer is semipermeable to allow gas to diffuse from the gaseous reservoir toward the wound, and to allow moisture to be absorbed from the wound. A spacer layer separates the external and internal layers and absorbs fluid from the wound. A bendable, flexible and stretchable, film-based circuit board is located on the internal layer and includes a processor, at least one sensor, and a wireless transceiver. A perforated inner wound layer is positioned below the circuit board and includes openings configured to allow the at least one sensor to be in communication with the wound.

Provided herein are devices and methods for the treatment of skin conditions. A skin treatment apparatus according to the present disclosure generally includes a treatment head defining a treatment space, the treatment head having a body forming said treatment space. The body is further configured to contact the treatment space to a treatment surface containing a lesion. A treatment media is disposed within the treatment space. The skin treatment apparatus also includes a heating element configured to heat the treatment media.