Reduced column loading of a sample onto a chromatographic column may be mitigated by excluding diffuse portions of the sample from introduction to the column. Systems and methods are provided for detecting and removing the diffuse portions from the feed solution delivered to the chromatography column. The systems and methods herein permit use of a single detector to detect and remove the diffuse portions and can accommodate a recovery/collection/recycling mechanism permitting reuse of removed sample from the diverted diffuse portions.

Reduced column loading of a sample onto a chromatographic column may be mitigated by excluding diffuse portions of the sample from introduction to the column. Systems and methods are provided for detecting and removing the diffuse portions from the feed solution delivered to the chromatography column. The systems and methods herein permit use of a single detector to detect and remove the diffuse portions and can accommodate a recovery/collection/recycling mechanism permitting reuse of removed sample from the diverted diffuse portions.

Disclosed is a chromatography system (100) comprising: plural modules (1-25) including at least one pump and a column valve unit (8) connectable to plural chromatography columns; and a controller (600), the controller being operable to control the or each pump and the column valve to perform different chromatographic processes, including chromatography employing just one column, as well as chromatography employing two or more columns by selective valve opening in said unit. The system includes a housing (110) into which the plural modules (1-25) are interchangeably mountable in apertures of one generally vertical face of housing, the modules are adapted for selective fluidic interconnection by tubing substantially at said one face such that in use the modules and tubing occupy a generally vertically extending volume to minimize the footprint of the system.

Disclosed is a chromatography system (100) comprising: plural modules (1-25) including at least one pump and a column valve unit (8) connectable to plural chromatography columns; and a controller (600), the controller being operable to control the or each pump and the column valve to perform different chromatographic processes, including chromatography employing just one column, as well as chromatography employing two or more columns by selective valve opening in said unit. The system includes a housing (110) into which the plural modules (1-25) are interchangeably mountable in apertures of one generally vertical face of housing, the modules are adapted for selective fluidic interconnection by tubing substantially at said one face such that in use the modules and tubing occupy a generally vertically extending volume to minimize the footprint of the system.

The present disclosure discloses a gas chromatograph-ion mobility spectrometry combined equipment, including: a gas chromatograph device for pre-separating a to-be-detected sample to form a pre-separated sample; an ion mobility spectrometry device in fluid communication with an outlet of the gas chromatograph device for detecting the pre-separated sample; and a gas circulating device in fluid communication with a discharged gas interface of the ion mobility spectrometry device for processing a discharged gas from the ion mobility spectrometry device, wherein the gas circulating device is further in gas communication with the gas chromatograph device for conveying a part of the discharged gas to the gas chromatograph device to serve as a carrier gas, which drives the to-be-detected sample to enter the gas chromatograph device. The miniaturization and the portability of the gas chromatograph-ion mobility spectrometry combined equipment are improved.

The present disclosure discloses a gas chromatograph-ion mobility spectrometry combined equipment, including: a gas chromatograph device for pre-separating a to-be-detected sample to form a pre-separated sample; an ion mobility spectrometry device in fluid communication with an outlet of the gas chromatograph device for detecting the pre-separated sample; and a gas circulating device in fluid communication with a discharged gas interface of the ion mobility spectrometry device for processing a discharged gas from the ion mobility spectrometry device, wherein the gas circulating device is further in gas communication with the gas chromatograph device for conveying a part of the discharged gas to the gas chromatograph device to serve as a carrier gas, which drives the to-be-detected sample to enter the gas chromatograph device. The miniaturization and the portability of the gas chromatograph-ion mobility spectrometry combined equipment are improved.

The present invention describes a device for distributing incoming fluid or for collecting fluid being discharged from a column forming part of an assembly of N columns in series intended to be used in a simulated moving bed separation process. The present device can be used to very substantially reduce the non-selective volumes at each column, while at the same time providing the flow with good synchronicity.

The present invention describes a device for distributing incoming fluid or for collecting fluid being discharged from a column forming part of an assembly of N columns in series intended to be used in a simulated moving bed separation process. The present device can be used to very substantially reduce the non-selective volumes at each column, while at the same time providing the flow with good synchronicity.

An apparatus for a selective fractionation of ultrafine particles includes at least three separating columns fluidically connected in series by connecting lines. An infeed is arranged to feed into a connecting line which is arranged upstream of each separating column. Each connecting line comprises an inlet for a suspension of ultrafine particles to be separated and an inlet for at least one additional mobile phase. The inlets are alternately operated. A discharge branches off from a connecting line which is arranged downstream of each separating column. Each connecting line comprises an outlet for a first and a second discharge suspension of the ultrafine particles. The outlets are alternately operated. A control means provides a simultaneous switching of the through-flow switching position of the shutoff valves at the inlets and outlets. At least one magnetic field source for a magnetic field is arranged in each separating column.

The disclosure relates to a recycling chromatography method that includes injecting a sample into a mobile phase flow stream of a chromatography system to create a combined flow stream. The sample includes an API and at least one impurity. The chromatography system includes a first column and a column in series, a first valve in fluid communication with the first and second chromatographic columns, a heater in communication with the first and second chromatographic columns, a fraction collector in fluid communication with the first and second chromatographic columns, and a second valve positioned before the fraction collector. The combined flow stream is recycled from the first chromatographic column to the second chromatographic column and vice versa by switching the first valve until a baseline resolution is achieved to separate the at least one impurity from the API. The at least one impurity is collected in the fraction collector.