Methods of entrapping enzymes in chitosan matrices using mild conditions, such as methods that are compatible with the entrapment of acid-sensitive and/or heat sensitive enzymes, are described. The methods can provide biocatalytic materials with high chitosan to enzyme mass ratios where one or more enzymes can remain active and stably entrapped in the chitosan matrix for many months and/or after repeated washings. Also described are materials including a solid chitosan matrix having at least one enzyme stably entrapped therein, including fabrics, textiles and other flexible materials at least partially coated with one or more layer of the solid chitosan matrix having at least one enzyme stably entrapped therein and the use of the materials as biocatalyst systems, for example in biogas upgrading and other applications.

A compression garment having first and second sections includes a stay up device for supporting the compression garment in position on the body. The stay up device is constructed to operatively engage a portion of the body to positively locate the stay up device, and thereby the garment relative to the body.

Dressings, systems, and methods are disclosed for treating tissue with reduced pressure. A dressing for distributing reduced pressure to a tissue site includes a plurality of liquid-impermeable layers that are stacked and a plurality of spacers disposed at least partially between adjacent liquid-impermeable layers. The plurality of liquid-impermeable layers are fenestrated at least in part. The plurality of spacers and plurality of liquid-impermeable layers form a plurality of flow paths for allowing fluid flow under reduced pressure. Adjacent layers of the plurality of liquid-impermeable layers are stacked without foam between at least a majority of coextensive surfaces. Other dressings, systems, and methods are disclosed.

A dressing for treating tissue with negative pressure may be a composite of dressing layers, including a release film, perforated gel layer, a perforated polymer film, a manifold, and an adhesive cover. A method of manufacturing the dressing may comprise providing a first layer, such as the gel layer, on a substrate, perforating the first layer on the substrate to create a plurality of apertures in the first layer, and creating an index of the plurality of apertures in the first layer. A laser can be calibrated based on the index. A second layer, such as the polymer film, may be coupled to the first layer, and a plurality of slots can be cut in the second layer with the laser. Each of the slots can be cut through one of the apertures in the first layer based on the index.

A wound dressing is in the form of a strip or a ribbon. The strip or ribbon is made of gel-forming fibers and has longitudinal lines of stitches formed from a thread and transverse lines of stitches formed from a thread.

A wound covering includes a flexible main body, and a sensor element incorporated into the main body. The sensor element includes a mesh formed from a plurality of fibers, and is configured to undergo a change in appearance in response to a change in a parameter associated with wound exudate. The wound covering further includes a supply of therapeutic agent configured to diffuse therapeutic agent from the wound covering into a wound when the wound covering is placed on a wound.

Methods and tooling for making three-dimensional substrates and/or apertured substrates are provided. The three-dimensional substrates and/or apertured substrates may be used in absorbent articles, such as diapers and pants, for example. The methods and tooling may be used on an absorbent article manufacturing line.

The present invention relates to a negative pressure wound closure system and methods for using such a system. Preferred embodiments of the invention facilitate closure of the wound by preferentially contracting to provide for movement of the tissue. Preferred embodiments can utilize tissue securing portions that aid in securing the invention within a wound.

A wound product and a method of manufacturing the wound product is provided. The wound product comprises a first layer comprising a plurality of splittable fibres. At least some of the plurality of splittable fibres are split longitudinally along at least part of their length, and at least some of the plurality of splittable fibres are entangled.

Disclosed embodiments relate to dressings for treating a tissue site with negative pressure. Some dressing embodiments may be configured to allow the depth of the dressing to be expandable. For example, dressing embodiments may comprise a segmented manifold having one or more vertical expansion joints between segments of the manifold. Some embodiments may comprise a first layer adjacent to a first surface of the manifold and a second layer adjacent to a second surface of the manifold. In some embodiments, the first layer may comprise one or more folds configured to extend between adjacent segments, and the second layer may also comprise one or more folds configured to extend between adjacent segments; and the folds in the first layer may match the folds in the second layer to jointly form the vertical expansion joints. Additionally disclosed are other apparatus, dressings, systems, and methods.