Methods of entrapping enzymes in chitosan matrices using mild conditions, such as methods that are compatible with the entrapment of acid-sensitive and/or heat sensitive enzymes, are described. The methods can provide biocatalytic materials with high chitosan to enzyme mass ratios where one or more enzymes can remain active and stably entrapped in the chitosan matrix for many months and/or after repeated washings. Also described are materials including a solid chitosan matrix having at least one enzyme stably entrapped therein, including fabrics, textiles and other flexible materials at least partially coated with one or more layer of the solid chitosan matrix having at least one enzyme stably entrapped therein and the use of the materials as biocatalyst systems, for example in biogas upgrading and other applications.

A wound dressing comprising: a water-absorbent fabric comprising at least about 10 wt. % of hydrogel-forming absorbent fibers based on the dry weight of the fabric; and an adhesion-resistant, water-permeable wound contacting surface textile layer that is substantially continuously bonded to at least one surface of said fabric. The surface textile layer may be formed by surface treatment of the fabric, or by bonding a suitable textile web to the surface of the fabric.

A bandaging system relating to assisting improved wound compression, wound stability, and wound-management of wound sites and other wound care.

A method of preparing a crosslinked, collagen-based wound care dressing is provided, comprising: (a) immersing a sample of fibrous and/or non-fibrous collagen in a buffered acidic, aqueous solution comprising an alcohol; (b) contacting the collagen in solution with a catalytic component comprising 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride for a time at least sufficient to effect reaction between amino and carboxyl groups present on the collagen and to yield crosslinked collagen that is resistant to pronase degradation; and (c) drying the crosslinked collagen to yield a porous, crosslinked collagen article wherein the porous, crosslinked collagen article demonstrates a pore size of 10-500 microns. Also provided are bioactive collagen medical scaffolds for hernia repair prosthetics and surgical incision closure members, prepared using the method above.

The present invention is directed to a flowable hemostatic paste comprising a crosslinked carboxymethyl cellulose and at least one non-toxic dispersant. More specifically the present invention relates to a hemostatic paste containing citric acid cross-linked CMC, which is suspended or dispersed as a powder in a mixture of a first non-toxic glycerol-containing hygroscopic dispersant and a second non-toxic alcohol functionalized dispersant comprising propylene glycol or 1,3-butanediol.

The present application provides a negative pressure wound dressing, including foam and a bio-cellulose film with a three-dimensional reticular structure formed on a surface of the foam, wherein a projected area of the bio-cellulose film on a bonding surface of the foam and the bio-cellulose film is greater than or equal to that of the foam. The presence of the bio-cellulose film between the foam and a wound avoids the foam from sticking to the wound and the growth of new tissue into the foam when performing a negative pressure wound therapy. Also, when replacing the foam, a secondary damage to the wound is reduced, so as to relieve pain that the patient suffers.

Patch (1) for regenerating biological tissues in patients and method of manufacture associated with the same, comprising a collagen membrane (2) which comprises cells with a regenerative character; and at least one reinforcement element (3a, 3b) configured to increase the rigidity of said membrane (2), preventing the deformation of said membrane (2) during the handling thereof; wherein said reinforcement element (3a, 3b) can be a perimeter frame (3a) and/or a crossed attachment (3b) between the ends of said membrane (2); which provides a patch (1) which can be applied to any type of biological organ with maximum assurances of success as well as reducing the application time.

Disclosures of the present invention describe a double-layer dressing containing silk fibroin and a method for making the same. The double-layer dressing mainly comprises a silk fibroin layer and a calcium-degradation silk fibroin layer connected to the silk fibroin layer. It is worth emphasizing that, results of animal experiment have proved that this novel double-layer dressing is an outstanding hemostatic wound dressing. Moreover, additional adhesion, resulted from the solidification of tissue fluid, can be effectively prevented from forming between skin wound and wound dressing under the use of this double-layer dressing.

The present invention provides a biological fiber composite dressing. The biological fiber composite dressing includes: a cloth membrane having a first surface layer and an opposing second surface layer, wherein the cloth membrane has cloth membrane fibers; and a biological fiber membrane having a third surface layer and an opposing fourth surface layer, wherein the biological fiber membrane is formed by bacteria of the genus Gluconacetobacter, and the fourth surface layer is combined with the first surface layer, and a plurality of biological fibers being wound and combined with the cloth membrane fibers are extended along the fourth surface layer of the biological fiber membrane, such that the moisturizing effect of the dressing can be enhanced by the biological fiber membrane, thereby carrying more active ingredients.

Disclosed herein are dressings capable of filtering, capturing, and/or releasing select biological molecules from wound exudate. In one embodiment, the dressing may include a permeable, non-adherent envelope. The permeable, non-adherent envelope may enclose a composition comprising milled hydrophobic foam.