Certain configurations described herein are directed to autosamplers. In some instances, the autosampler may include a support comprising a body configured to receive two or more articles at separate sites of the body. The autosampler may also include a first motor coupled to the support and configured to rotate the support in an x-y plane, and a second motor configured to move the support in a z-direction to load one of the at least two articles at the separate sites in the body of the support. An encoder may also be used with the autosampler if desired.

In an example, a method for preparing a nucleotide solution includes flowing an aqueous solution from an initial solution storage of a sequencing instrument continuously through a container fluidically coupled to the sequencing instrument, the container comprising a nucleotide concentrate; and collecting the aqueous solution with nucleotide in a storage container.

An autosampler includes a carrier for receiving a plurality of sample containers each having a top end and a visible indicium. The visible indicia are located below a top plane defined by the top ends. The autosampler includes: an optical sensor configured to read the visible indicia and to generate a corresponding output signal, and having a line of sight; a controller configured to receive the output signal; and a sampling system to withdraw a sample from the sample containers. The autosampler is operative to relatively move the optical sensor and/or the carrier such that the line of sight intersects the visible indicium of a selected one of the sample containers, wherein the line of sight extends: downward from a height above the height of the top plane; at an oblique angle to the top plane; and through a gap between the selected sample container and an adjacent sample container.

Purifying target biomolecules, such as nucleic acids or proteins, from a biological source is a time intensive process and is typically performed by a skilled technician or scientist owing to the highly technical nature of the work. Systems, devices, and methods disclosed herein enable the automated bioprocessing and purification of target biomolecules from a biological source. For example, an instrument and disposable cartridge are provided for automatedly isolating and purifying nucleic acids (such as plasmid DNA from a bacterial culture) or for isolating protein from any biological sample. Such an exemplary instrument and cartridge can work in concert to timely release, mix, and move the target biomolecule and various reagents and buffers through a target biomolecule purification process, resulting in a purified target biomolecule with less manual oversight than traditional approaches.

The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a cooling, heating and fan arrangement for maintaining a predetermined optimum temperature of the samples during testing; a visual, circumferential and axial alignment system for aligning the samples within the carousel; a transfer system for transferring the samples from the carousel to the centrifuge; a balancing system of minimizing the rotational vibrations of the centrifuge; a safety system and anti-tipping design for the sample containing system; liquid dispensing arms for dispensing the buffered saline solution; and discharge ports for discharging and disposing of the liquid removed from the samples to a location external of the system.

Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

A sample transport method, applied to a test instrument including a conveyor belt, and a loading platform and a grab position sequentially disposed along a transport direction of the conveyor belt, wherein a plurality of sample holder transport positions are disposed on the conveyor belt; the method including: pushing a first sample holder from the loading platform to a sample holder transport position of the conveyor; when a sample position on the first sample holder moves to the grab position, determining whether the sample position moved the grab position is a target sample position; if so, then determining whether all samples positions on the first sample holder before the target sample holder other than a predetermined number of sample positions have completed testing, wherein the predetermined number is sample position number corresponding to a delay time in outputting information indicating whether a sample needs to be retested.

A continuous sample introduction method is provided. The method includes controlling a current sample holder advancing mechanism to perform an advancing operation according to a sample introduction trigger signal, so that the current sample holder advancing mechanism moves in a direction from an initial position to a limiting position, and during the movement, a pushing portion of the current sample holder advancing mechanism is capable of abutting against a side wall of a sample holder in a current sample loading device; controlling the current sample holder advancing mechanism to perform a returning operation when the current sample holder advancing mechanism moves to the limiting position, and during the movement, the pushing portion is capable of avoiding contacting with the sample holder; and the current sample holder advancing mechanism automatically repeats the advancing operation and the returning operation when the current sample holder advancing mechanism moves to the initial position.

An auto-navigating robotic processing vehicle including a carriage having a frame, an autonomous drive section configured to traverse the carriage effecting vehicle travel on a facility floor, and having an autonomous navigation section to effect autonomous navigation vehicle travel, a processing section with different processing modules connected to and carried by the frame, each of the different processing modules having a different predetermined laboratory processing function with a different predetermined function characteristic corresponding to the processing module and being automatically selectable to effect a preprocess or preprocess condition of laboratory samples and/or sample holders with respect to a process at a processing station, and a controller automatically selects at least one processing module and the corresponding predetermined function of the selected processing module effecting automatically the preprocess or preprocess condition based on an identification of a travel location for the vehicle and the process of the at the processing station.

A rolling cart configured at least for manual rolling across a facility floor to different locations of process stations with the rolling cart comprising a cart frame configured to traverse the cart, displacing the cart as a unit on and across the facility floor on which is disposed at least one of the process stations for processing laboratory samples and/or sample holders and a processing section with a number of different processing modules connected to and carried by the cart frame, each of the different processing modules having a different predetermined laboratory processing function with a different predetermined function characteristic corresponding to the processing module, each different processing module and corresponding predetermined function being automatically selectable in a predetermined sequence to effect automatically with the corresponding predetermined function, a predetermined series of preprocess or process conditions or steps of one or more of the laboratory samples and sample holders.