A non-contact deposition system comprises a jetting assembly including at least one micro-valve. The micro-valve includes an orifice plate defining an orifice therethrough. An actuating beam disposed in a spaced relationship to the orifice plate. The actuating beam including a base portion and a cantilevered portion extending from the base portion towards the orifice and is movable between a closed position and an open position. A sealing structure comprising a sealing member is disposed at the overlapping portion of the cantilevered portion. A fluid manifold is coupled to the micro-valve and defines a fluid reservoir containing a pressurized fluid. When the actuating beam is in the closed position, the cantilevered portion is positioned such that the sealing structure seals the orifice so as to close the micro-valve, and in the open position, the fluid is dispensed from the orifice towards a substrate and deposited thereon.

An alignment system, in an example, may include a substrate comprising at least one nanowell, at least one fluid ejection device comprising at least one die, the at least one die comprising as least one nozzle, and an alignment device to align the at least one nozzle to the at least one nanowell.

There is provided a sample ejection system for ejecting a sample from a flow of fluid, the system comprises: a fluid flow channel for receiving, in use, the flow of fluid; a fluid inlet channel connected to the flow channel and arranged to receive, in use, pressurised fluid; a fluid outlet channel connected to the flow channel at a location downstream in the flow direction of the flow of fluid and comprises an outlet. The system is arranged such that, in use, pressurised fluid is applied to the fluid flow channel via the fluid inlet channel to drive fluid from the region of the fluid flow channel between the fluid inlet and outlet channels through the fluid outlet channel and out of the outlet.

Provided are: a device for storing biochemical reagents wherein an amount of a reagent can be hermetically stored and dropped from a storage site without coming into contact with the outside air; and a biochemical analyzer using the device. The device (10) is constituted by: sticking a top sheet (32) to a base sheet (31) provided with a convex-shaped hollow pocket (16) in which a reagent can be housed; a reagent container as a PTP packaging sheet (30) wherein an opening of the pocket in the base sheet (31), in which a reagent is preliminarily housed, is hermetically sealed with the top sheet (32); and sticking the film sheet surface as the top sheet (32) of the PTP packaging sheet (30), in which the reagent is hermetically packaged, to a cartridge surface of a device body (20) to thereby hermetically seal the inside of the device body too.

A system and method for printing cells in a medium. A multi-dimensional printer, stably constructed of low-mass parts, can include a computer numerically controlled system that can enable motors driving delivery systems. The motors can include encoders that can enable achieving arbitrary resolution. The motors can drive ballscrews to enable linear motion of delivery systems, and the delivery systems can enable printing of a biological material in a pre-selected pattern in a petri dish. The petri dish can accommodate a medium such as a gel, and can further accommodate a vision system that can detect actual position and deflection of the delivery system needle. The printer can accommodate multiple delivery systems and therefore multiple needles of various sizes.

A resonating needle is adapted to be used in a device for measuring and controlling the dosage of a small quantity of fluid, includes: a needle (1) adapted to contain said small quantity of fluid; a resonating element of the piezoelectric type (2), coupled to said needle and adapted to be energized in order to detect variations of oscillation parameters of the needle and of the resonating element for the purpose of determining the dosage measurement and control.

A system for partitioning a liquid sample, the system including: an ejection device, the ejection device comprising an array of nozzles, wherein adjacent nozzles are separated by a constant distance in a first axis; and a microfluidics device including: a plurality of intake ports to receive a deposited droplet, wherein pairs of intake ports are separated by the same constant distance in the same first axis such that adjacent nozzles can simultaneously eject droplets to different intake ports.

A digital dispense system and methods for preparing samples for analysis. The digital dispense system includes a fluid droplet ejection system housed in a housing unit. The fluid droplet ejection system contains a fluid droplet ejection head and fluid cartridge containing one or more fluids to be dispensed. A cartridge translation mechanism is provided for moving the fluid droplet ejection head and fluid cartridge back and forth over a sample holder in an x direction. A sample tray translation mechanism moves a sample tray back and forth beneath the fluid droplet ejection head and fluid cartridge in a y direction orthogonal to the x direction.

A digital dispense system for preparing and analyzing a plurality of samples. The system includes two or more fluid droplet ejection devices. Each fluid droplet ejection device contains a fluid droplet ejection cartridge containing at least one fluid to be dispensed. The fluid droplet ejection cartridge is attached to a translation mechanism for moving the fluid droplet ejection cartridge back and forth over a sample holder in an x direction. A sample tray translation mechanism is provided for moving a sample tray along a production path in a y direction orthogonal to the x direction through the two or more fluid droplet ejection devices.

An open fluid droplet ejection cartridge containing one or more fluids to be dispensed by digital fluid dispense system and a method for digitally dispensing fluids. The open fluid droplet ejection cartridge includes a cover having one or more openings therein, fluid funnels pending from each of the one or more openings in the cover, a chamber separator attached to the fluid funnels for directing fluid to one or more fluid chambers, a fluid overflow chamber for fluid overflow from the one or more fluid chambers, fluid vias associated with each of the one or more fluid chambers, and a plurality of fluid ejection devices adjacent to the fluid vias on a single semiconductor substrate in fluid flow communication with the fluid vias.