A tissue processing apparatus for processing biological tissue. The tissue processing apparatus comprises a measurement probe that includes two measurement surfaces spaced apart from each other, wherein the measurement probe is configured to be inserted into a reagent receptacle so that the two measurement surfaces are at least partially immersed in reagent contained in the reagent receptacle. The tissue processing apparatus is configured to use the two measurement surfaces of the measurement probe to obtain at least one electrical measurement of reagent contained in the reagent receptacle before reagent is taken out from the reagent receptacle by the tissue processing apparatus. The tissue processing apparatus is configured to determine, based on the at least one electrical measurement, a concentration and/or a type of reagent contained in the reagent receptacle.

The present disclosure provides methods and devices for sample extraction.

A sample liquid-sending apparatus includes a placement portion, a suction mechanism, and a vibrator. A sample container is placed in the placement portion, the sample container containing a suspension of a sample. The suction mechanism includes a nozzle configured to be inserted into the sample container placed in the placement portion, and suctions the sample through the nozzle. The vibrator vibrates the nozzle.

A sample processing station includes two or more container holders on a platform that is rotatable about a central axis of rotation. Each holder is configured to rotate about a secondary axis of rotation. The station includes a capping/decapping mechanism to cap or decap a container held in one of the container holders and an elevator with a chuck guide that contact the container holder as the chuck is lowered by the elevator to positon the chuck with respect to the cap of the container held in the holder and to hold jaws of the container holder in a closed position. In embodiment, the chuck guide includes a yoke with opposed arms and spindles located near distal ends of the arms that engage beveled shoulders of the container holder.

A method and droplet dispenser for depositing single particles onto a target. For example, a single particle depositing method with improved rate of dispensing single particles and/or increased recovery of rare particles and/or with an extended applicability with different types of particles and/or operation conditions. The depositing method may be capable of increasing the rate of dispensing single cells without decreasing the recovery rate. Testing a single particle condition is combined with testing a zero particle condition and/or the particle type condition. The ejection and sedimentation regions are tested with regard to the presence of a single particle in the ejection, and further particle arrangements allowing a single particle deposition are identified and tested and/or the particle type detection is added to the dispenser control. Accordingly, the speed and recovery rate of dispensing single particles of interest can be improved.

Provided is a multiple biomarker simultaneous analysis apparatus comprising: a cartridge mounting portion 210 in which a cartridge 100 is installed, the cartridge 100 including at least one well and a tip 110, wherein the at least one well includes a sample well 101 into which a sample S containing a detection target material T is injected, and a reaction well 105 accommodating a first binding material 105a, which is specifically bound to the detection target material T and to which a marker R is coupled, and the tip 110 is inserted into the at least one well and a second binding material 111 that is specifically bound to the detection target material T is coupled to one end of the tip 110; a tip coupling portion 220 coupled to the tip 110 and movable on a predetermined movement trajectory while being coupled to the tip 110; an optical unit 230 radiating light toward the tip 110 and receiving light generated from the tip 110 according to light radiation; and a processing unit 240 determining whether the detection target material T is present in the sample S according to a predetermined method using the light received by the optical unit 230.

A pipette includes a capillary, a pressure chamber, a drive unit, and a control unit. The capillary has a first end and a second end that are two ends in a length direction and that are open. The pressure chamber communicates with an inside of the capillary via the second end. The drive unit changes a volume of the pressure chamber. The control unit controls the drive unit. The control unit outputs a vibrational movement signal that drives the drive unit so that a liquid moves from a mid-position in the capillary to a finish position that is located closer to the second end than the mid-position. The vibrational movement signal has a waveform that drives the drive unit so that the volume of the pressure chamber alternately increases and decreases repeatedly.

A cell picking device includes a stage, a sucker, a driver, a work content receiver, a registrar and a device controller. A sample container is placed on the stage. The driver is provided to execute sample scraping work and sample sucking work using a pipette tip attached to the sucker. In a case in which selection of work contents of the driver is received by the work content receiver, a work procedure including the received work contents of the driver is registered by the registrar. The work of the driver is controlled by the device controller in accordance with the registered work procedure.

A digital dispense system and method of using a digital dispense system. The digital dispense system includes a pipette-fillable fluid cartridge having one or more fluid chambers therein and having an ejection head attached thereto. The ejection head contains a plurality of fluid ejectors thereon. The fluid ejectors are in fluid flow communication with the one or more fluid chambers of the pipette-fillable fluid cartridge. A fluid detection circuit is disposed on the ejection head and associated with at least one of the plurality of fluid ejectors for signaling the presence or absence of fluid in the one or more fluid chambers.

A tissue processing apparatus for processing biological tissue. The tissue processing apparatus comprises a measurement probe that includes two measurement surfaces spaced apart from each other, wherein the measurement probe is configured to be inserted into a reagent receptacle so that the two measurement surfaces are at least partially immersed in reagent contained in the reagent receptacle. The tissue processing apparatus is configured to use the two measurement surfaces of the measurement probe to obtain at least one electrical measurement of reagent contained in the reagent receptacle before reagent is taken out from the reagent receptacle by the tissue processing apparatus. The tissue processing apparatus is configured to determine, based on the at least one electrical measurement, a concentration and/or a type of reagent contained in the reagent receptacle.