The present invention provides a light-field microscope including: an illumination optical system that radiates excitation light onto a sample; and a detection optical system including an objective lens that collects fluorescence generated in the sample as a result of the sample being irradiated with the excitation light by the illumination optical system, an image-acquisition element that acquires an image of the fluorescence collected by the objective lens, and a microlens array disposed between the image-acquisition element and the objective lens. The illumination optical system radiates a beam of the excitation light having a predetermined width in the optical-axis direction of the objective lens so as to include the focal plane of the objective lens onto the sample in a direction substantially perpendicular to the optical axis.

Spectrophotometer system configured to characterize and/or measure spectrally (wavelength)-dependent properties of material components (such as molecular, viral, and/or bacterial analytes) associated with or of an object prior to the time when optical fingerprints of such material components start to degrade, and associated methods. System can be enhanced by a capability of selecting specific wavelengths of operation for such system to optimize cost-efficiency of the system.

An integrated circuit includes a photodetection region configured to receive incident photons. The photodetection region is configured to produce a plurality of charge carriers in response to the incident photons. The integrated circuit also includes at least one charge carrier storage region. The integrated circuit also includes a charge carrier segregation structure configured to selectively direct charge carriers of the plurality of charge carriers into the at least one charge carrier storage region based upon times at which the charge carriers are produced.

Measurement device for the detection and/or characterization of fluid-borne particles featuring a laser positioned for emitting pulses of laser light polarized in a first direction, in a measurement volume of a fluid flow path, each pulse having a pulse duration, and a means for directing the laser pulses polarized in a second different direction of polarization in the measurement volume. An optical spectrometer captures fluorescent light emitted by individual fluid-borne particles and measures the intensity of at least one wavelength at a sampling rate of at least three samples per pulse. The means for directing are configured to direct laser light polarized in the second direction each time a pulse of laser light crosses the measurement volume, the time delay between the two crossings being longer than the pulse duration and shorter than a travel time of the fluid in the measurement volume.

The present disclosure provides techniques for improving the rate and efficiency of charge transfer within an integrated circuit configured to receive incident photons. Some aspects of the present disclosure relate to integrated circuits that are configured to induce one or more intrinsic electric fields that increase the rate and efficiency of charge transfer within the integrated circuits. Some aspects of the present disclosure relate to integrated circuits configured to induce a charge carrier depletion in the photodetection region(s) of the integrated circuits. In some embodiments, the charge carrier depletion in the photodetection region(s) may be intrinsic, in that the depletion is induced even in the absence of external electric fields applied to the integrated circuit. Some aspects of the present disclosure relate to processes for operating and/or manufacturing integrated devices as described herein.

A photoacoustic flow cytometry (PAFC) device for the in vivo detection of cells circulating in blood or lymphatic vessels is described. Ultrasound transducers attached to the skin of an organism detect the photoacoustic ultrasound waves emitted by target objects in response to their illumination by at least one pulse of laser energy delivered using at least one wavelength. The wavelengths of the laser light pulse may be varied to optimize the absorption of the laser energy by the target object. Target objects detected by the device may be unlabelled biological cells or cell products, contrast agents, or biological cells labeled with one or more contrast agents.

An integrated circuit includes a photodetection region configured to receive incident photons. The photodetection region is configured to produce a plurality of charge carriers in response to the incident photons. The integrated circuit also includes at least one charge carrier storage region. The integrated circuit also includes a charge carrier segregation structure configured to selectively direct charge carriers of the plurality of charge carriers into the at least one charge carrier storage region based upon times at which the charge carriers are produced.

A characteristic information extraction method of a small-molecule volatile substance, including: dividing a surface-enhanced Raman scattering (SERS) spectrum of the small-molecule volatile substance to obtain n wavelength subintervals, where n is a positive integer; sampling the n wavelength subintervals through weighted bootstrap sampling (WBS) to obtain Wwavelength subintervals, where W is a positive integer less than n; and screening the W wavelength subintervals to obtain desired wavelength subintervals. This application also provides a rapid detection method and a portable detection system of a small-molecule volatile substance.

A 3-dimensional measuring device includes: a light source unit; a projection optical system; a scanning mirror that is provided to be rotatable about a rotating shaft in a state of being inclined with respect to a shaft center of the rotating shaft to radiate a range-finding light within a plane crossing the rotating shaft in a rotary manner; a light-receiving optical system that receives a reflection range-finding light; a reference light optical system that is provided in a range outside a measuring range within a radiation range to receive and reflect the range-finding light as an internal reference light, the reference light optical system being capable of changing a light quantity of the internal reference light; and a light receiving element that receives the reflection range-finding light and the internal reference light.

A terahertz light detector includes: a light reception unit that receives terahertz light from a measured object; a pulse laser that generates pulse light; an optical member which the pulse light enters; and a control unit that controls the energy of the pulse light which enters the optical member, wherein the optical member has anomalous dispersion, and the light reception unit outputs a signal that is dependent on an intensity of terahertz light when the pulse light emitted from the optical member enters the light reception unit.