[Purpose] The disclosure provides a package structure of an agent for skin external application, which is unfolded upon the opening of the package structure and very easily separated from the stack structure, and a method of fabricating the package structure for the agent for skin external application. [Constitution] An agent 2 for skin external application is interposed between a film-type base material 3 and a film-type cover material 4, the resultant product is folded by employing the cover material 4 as a folding surface, and the four-layer overlap material including the base material 3-the cover material 4-the cover material 4-the base material 3 provided at a peripheral portion of the folded structure is closed through thermal bonding.

A device for translaminating tension-sensitive films from a first liner to a second liner, wherein the device has a first transport device, a second transport device, and a laminating device. The first transport device is configured to transport a first laminated strip to a film delaminating station. The second transport device is configured to transport a second strip-shaped liner to the laminating device, which is designed to laminate the tension-sensitive film onto the second liner in order to form a second laminated strip. The first transport device and the laminating device are arranged relative to each other such that the tension-sensitive film is pulled off at the film delaminating station in the direction opposite the running direction of the first laminated strip at said station.

The invention relates to a patch for administering an active substance to the skin of a subject. The present patches simplify manufacture and improve reproducibility of results, facilitate, and enhance the consistency of application of the patches to a subject, and demonstrate improved initial and long-term adhesion with reduced risk of premature detachment.

This disclosure relates to a transdermal therapeutic system (TTS) containing pramipexole or related compounds and methods of making the system as well as its use in administering such compounds as a single dose over an extended period, for example, one week. The system comprises an acrylic-based or silicone-based matrix layer containing pramipexole at concentrations of at least about 5 wt. % of the matrix, which is resistant to crystallizing and discoloration of the active ingredient even when stored over long periods.

A manufacturing method of a microstructure includes providing a patch manufacturing sheet formed in a state in which a bottom layer is exposed on an upper part thereof; providing the patch manufacturing sheet on a first process substrate and a second process substrate; spotting a viscous composition at a plurality of positions spaced apart from each other on the bottom layer of the patch manufacturing sheet provided on only the first process substrate, or provided on both of the first process substrate and the second process substrate; contacting the patch manufacturing sheet provided on the second process substrate or the viscous composition to the viscous composition spotted on the patch manufacturing sheet provided on the first process substrate; moving relatively the second process substrate with respect to the first process substrate to stretch the viscous composition and to coagulate the stretched viscous composition; and cutting the coagulated viscous composition.

Disclosed are a microneedle patch including a first hydrogel layer containing a mussel adhesive protein and hyaluronic acid, and a second hydrogel layer containing silk fibroin, and a preparation method thereof. The microneedle patch according to the present disclosure has excellent tissue adhesion, biocompatibility, and biodegradability, and is used for transdermal drug delivery to promote wound regeneration.

A method for manufacturing a steel sheet having a yield strength YS of more than 1000 MPa, a tensile strength TS of GP more than 1150 MPa and a total elongation E of more than 8%, comprising the steps of: preparing a steel sheet through rolling from a steel containing in percent by weight 0.19% to 0.22% C, 2% to 2.6% Mn, 1.45% to 1.55% Si, 0.15% to 0.4% Cr, less than 0.020% P, less than 0.05% S, less than 0.08% N, 0.015% to 0.070% Al, the reminder being Fe and unavoidable impurities, soaking the sheet at an annealing temperature TA between 860 C. and 890 C. for a time between 100 s and 210 s, cooling the sheet to a quenching temperature QT between 220 C. and 330 C., from a temperature TC not less than 500 C. at a cooling speed not less than 15 C./s, heating the steel sheet during a time between 115 s and 240 s up to a first overaging temperature TOA1 higher than 380 C., then heating the sheet during a time between 300 s and 610 s up to a second overaging temperature TOA2 between 420 and 450 C., cooling the steel sheet to a temperature less than 100 C. at a cooling speed less than 5 C./s. The structure of the steel containing more than 80% of tempered martensite, more than 5% of retained austenite, less than 5% of ferrite, less than 5% of bainite and less than 6% of fresh martensite.

The present invention relates to a device for the manufacture of pharmaceutical patches, a method for the manufacture of pharmaceutical patches, and a package comprising a pharmaceutical patch obtainable by said method.

A hydrocolloid-based skin patch that includes ozonated olive oil absorbed within a hydrocolloid layer, and a release layer overlying one side of the hydrocolloid layer.

The present invention falls within the area of polymeric materials based on ultrafine fibres for use in the pharmaceutical, nutraceutical and cosmetic sector, relating to the method of producing self-adhesive patches and the use thereof as a platform for the controlled release of bioactives by electrohydrodynamic and/or aerohydrodynamic processing techniques.