In one aspect, the disclosure relates to an aerial viral detection device comprising a sensor cartridge comprising at least one sensor, the at least one sensor comprising a self-hydrating hygroscopic surface and an integrated conductive polymer or nanoparticle network. In one aspect, the device further comprises a conductive component and a binding agent, the binding agent binding the conductive component to the hygroscopic surface. The aerial viral detection device further comprises an active element and a control element disposed in the sensor cartridge, wherein the control element includes all features of the active element with the exception of a molecular receptor such as an antibody. The disclosed devices, systems, and methods can rapidly detect COVID-19, influenza, RSV, and/or other infectious agents from air samples within a room in real time. The system disclosed herein can operate on the principle of electron hopping to detect viral particles with high sensitivity.

The present invention relates to the field of immunology and molecular virology, and in particular relates to the field of the prevention and treatment of RSV. Specifically, provided are a monoclonal antibody capable of specifically binding to a new epitope between an epitope and a V epitope on a pre-F protein or a new epitope between an II epitope and a V epitope, and the use thereof in the detection, prevention and/or treatment of RSV infection and/or diseases caused by the infections.

The invention relates to human isolated, synthetic or recombinant antibodies or functional parts thereof, specific for the RSV G protein. Antibodies specific for the RSV G protein are particularly suitable for counteracting RSV and symptoms, such as inflammation, resulting from an RSV infection. The invention further relates to the use of such RSV G-specific antibodies for diagnosis of an RSV infection and as a medicament and/or prophylactic agent for at least in part treating or alleviating symptoms of a Respiratory Syncytial Virus infection and/or a Respiratory Syncytial Virus related disorder.

The invention relates to a DDX3X inhibitorfor use in the treatment of pneumovirus infection in a mammal, wherein the DDX3X inhibitor may be a compound of Formula (I) wherein y, Z, R.sup.1, X, L, R.sup.a and R.sup.b are as defined herein. The invention also relates to compounds of Formula (I).

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The present disclosure provides methods for determining the presence or absence of and/or the etiology of an acute respiratory viral infection in a subject, as well as methods of treating the subject based on the determination, by measuring on a platform the expression levels of a pre-defined set of gene products.

The present invention provides fully human antibodies that bind to respiratory syncytial virus F protein, compositions comprising the antibodies and methods of use. The antibodies of the invention are useful for preventing fusion of the virus with the cell membrane and preventing cell to cell spread of the virus, thereby providing a means of preventing the infection, or treating a patient suffering from the infection and ameliorating one or more symptoms or complications associated with the viral infection. The antibodies may also be useful for diagnosis of an infection by RSV.

The present disclosure relates generally to compositions, methods, and systems for the characterization of antigen-binding molecules, e.g., multispecific T cell receptors, B cell receptors, antibodies, and antigen-binding fragments thereof, using single-cell immune profiling methodologies. The compositions, methods and systems described herein permit rapid, high-throughput identification and characterization of multispecific antigen binding molecules having desired properties.

The present disclosure relates to a novel anti-respiratory syncytial virus (RSV) monoclonal antibody, a method for preparing the antibody, and related applications thereof for immunoassay. The anti-RSV monoclonal antibody of the present disclosure exhibits high sensitivity and high specificity against RSV, and thus can be used for RSV detection at a nanoscale concentration on a chromatographic platform, and achieve more sensitive detection at a picoscale concentration in other platforms such as those for chemiluminescent assays.