Embodiments of a compact portable nuclear magnetic resonance (NMR) device are described which generally include a housing that provides a magnetic shield; an axisymmetric permanent magnet assembly in the housing and having a bore, a plurality of magnetic elements that together provide a well confined axisymmetric magnetization for generating a near-homogenous magnetic dipole field B.sub.0 directed along a longitudinal axis and providing a sample cavity for receiving a sample, and high magnetic permeability soft steel poles to improve field uniformity: a shimming assembly with coils disposed at the longitudinal axis for spatially correcting the near homogenous magnetic field B.sub.0; and a spectrometer having a control unit for measuring a metabolite in the sample by applying magnetic stimulus pulses to the sample, measuring free induction delay signals generated by an ensemble of hydrogen protons within the sample; and suppressing a water signal by using a dephasing gradient with frequency selective suppression.

Embodiments of a compact portable nuclear magnetic resonance (NMR) device are described which generally include a housing that provides a magnetic shield; an axisymmetric permanent magnet assembly in the housing and having a bore, a plurality of magnetic elements that together provide a well confined axisymmetric magnetization for generating a near-homogenous magnetic dipole field B.sub.0 directed along a longitudinal axis and providing a sample cavity for receiving a sample, and high magnetic permeability soft steel poles to improve field uniformity: a shimming assembly with coils disposed at the longitudinal axis for spatially correcting the near homogenous magnetic field B.sub.0; and a spectrometer having a control unit for measuring a metabolite in the sample by applying magnetic stimulus pulses to the sample, measuring free induction delay signals generated by an ensemble of hydrogen protons within the sample; and suppressing a water signal by using a dephasing gradient with frequency selective suppression.

Embodiments of a compact portable nuclear magnetic resonance (NMR) device are described which generally include a housing that provides a magnetic shield; an axisymmetric permanent magnet assembly in the housing and having a bore, a plurality of magnetic elements that together provide a well confined axisymmetric magnetization for generating a near-homogenous magnetic dipole field Bo directed along a longitudinal axis and providing a sample cavity for receiving a sample, and high magnetic permeability soft steel poles to improve field uniformity: a shimming assembly with coils disposed at the longitudinal axis for spatially correcting the near homogenous magnetic field Bo; and a spectrometer having a control unit for measuring a metabolite in the sample by applying magnetic stimulus pulses to the sample, measuring free induction delay signals generated by an ensemble of hydrogen protons within the sample; and suppressing a water signal by using a dephasing gradient with frequency selective suppression.

A novel method for measurement of velocity and diffusion constant in microfluidic channels is presented using nano-NMR techniques. The fluid molecules of interest interact with color centers implanted in a suitable substrate such as diamond. A magnetic dipolar interaction between the fluid molecule spins influences the state of the NV, which can be probed using known NMR techniques. The color center response is read out optically and the NMR spectrum can be reconstructed from this optical information.

The noise in the NMR spectra can be analyzed (e.g. in terms of its correlation function) to directly yield measurements of velocity and diffusion constant in the fluid, at orders of magnitude greater accuracy than otherwise possible.

A device for generating and detecting a transient magnetization of a includes a static magnetic field generator configured to generate a static magnetic field of predetermined direction and strength at a sample location, a transmission device for providing a transient magnetic field at the sample location; and a receiving device for detecting a transient magnetization of the sample at the sample location. An LC oscillator forms both the transmission device and the receiving device. An oscillation frequency of the LC oscillator depends on a value of an inductive element of the LC oscillator. A controller configured to control the LC oscillator is connected, and a transient magnetic field can be generated by the LC oscillator and the controller that is capable of deflecting a magnetization of a sample out of equilibrium.

A liquid-state nuclear-magnetic-resonance measurement cell includes a reservoir for a liquid medium; a fluidic circuit connected to the reservoir and comprising a measurement chamber; a gas injector opening into the fluidic circuit, at a distance from the measurement chamber; and a coil encircling the measurement chamber; wherein it also comprises at least one capacitive element forming, with the coil, an electromagnetic resonator; and in that it has a shape allowing its introduction into a nuclear-magnetic-resonance probe in replacement of an assembly formed by a nuclear-magnetic-resonance tube and a spinner bearing the tube, the coil encircling the measurement chamber being then positioned so as to couple by induction to at least one radiofrequency coil of the probe. Nuclear-magnetic-resonance measurement system comprising such a measurement cell. Magnetic-resonance measurement method using such a cell is also provided.

This invention relates generally to detection devices having one or more small wells each surrounded by, or in close proximity to, an NMR micro coil, each well containing a liquid sample with magnetic nanoparticles that self-assemble or disperse in the presence of a target analyte, thereby altering the measured NMR properties of the liquid sample. The device may be used, for example, as a portable unit for point of care diagnosis and/or field use, or the device may be implanted for continuous or intermittent monitoring of one or more biological species of interest in a patient.

Technologies relating to a magnetic resonance spectrometer are disclosed. The magnetic resonance spectrometer may include a doped nanostructured crystal. By nanostructuring the surface of the crystal, the sensor-sample contact area of the crystal can be increased. As a result of the increased sensor-sample contact area, the output fluorescence signal emitted from the crystal is also increased, with corresponding reductions in measurement acquisition time and requisite sample volumes.

Described herein are micro-coil hyperpolarized NMR systems and methods for measuring metabolic flux in living and non-living samples. Such systems can perform high throughput measurements (with multiple coils) of metabolic flux without destroying the material, making it useful to analyze tumor biopsies, cancer stem cells, and the like. In certain embodiments, a hyperpolarized micromagnetic resonance spectrometer (HMRS), described herein, is used to achieve real-time, significantly more sensitive (e.g., 10.sup.3-fold more sensitive) metabolic analyses of live cells or non-living samples. In this platform, a suspension mixed with hyperpolarized metabolites is loaded into a miniaturized detection coil (e.g., about 2 L), where the flux analysis can be completed within a minute without significant changes in viability. The sensitive and rapid analytical capability of the provided systems enables rapid assessment of metabolic changes by a given drug, which may direct therapeutic choices in patients.

An NMR spectroscopy system for studying a region of a sample to be analysed, includes a magnetoresistive transducer made up of superposed planar layers, which receives a response signal of the sample; a system for making an AC current flow, at a supply frequency f.sub.c, through the transducer; a system for generating a magnetic field H.sub.0 that is constant and uniform throughout a zone of interest in which the sample and transducer are placed; and an exciting coil to generate a magnetic field H.sub.1 that is uniform throughout the zone of interest and that varies at a resonant frequency f.sub.1; the field H.sub.0 is substantially perpendicular to the layers of the transducer. The system further includes a regulating system to ensure that the field H.sub.0 and the planar layers remain orthogonal, and a system for detecting a signal of frequency f.sub.cf.sub.1, f.sub.1f.sub.c or f.sub.c+f.sub.1.