The present invention provides a method for determining the 3-dimensional or 3-D atomic resolution structure of a biomolecule using chemical shift data obtained from the biomolecule having one or more selectively isotopically labeled biomolecule monomers and interrogation of same using an NMR device. Methods also comprise use of a low-field NMR device and structure determination method to determine the 2-D and 3-D structure of the biomolecule, for example, a polynucleotide.

An apparatus for an atomic clock includes first and second distinctive substrates, each having at least a planar surface substantially parallel therebetween. The apparatus also includes a medium having particles capable of undergoing energetic transition between at least two energy levels, said medium being located in the space defined between the planar surfaces. It further includes a magnetic device arranged to the first substrate and generating at least in the volume of the medium a predetermined static magnetic field B the direction of which is substantially parallel or perpendicular to the planar surfaces and an excitation device arranged to the second substrate and generating an excitation magnetic field H at, at least an excitation frequency, the direction of said excitation magnetic field H in the volume of the medium being substantially orthogonal to said direction of the static magnetic field B.

A device for generating and detecting a transient magnetization of a includes a static magnetic field generator configured to generate a static magnetic field of predetermined direction and strength at a sample location, a transmission device for providing a transient magnetic field at the sample location; and a receiving device for detecting a transient magnetization of the sample at the sample location. An LC oscillator forms both the transmission device and the receiving device. An oscillation frequency of the LC oscillator depends on a value of an inductive element of the LC oscillator. A controller configured to control the LC oscillator is connected, and a transient magnetic field can be generated by the LC oscillator and the controller that is capable of deflecting a magnetization of a sample out of equilibrium.

A nuclear magnetic resonance (NMR) apparatus includes at least one magnet arranged to induce a static magnetic field in a sample chamber. The static magnetic field has a known amplitude distribution. At least one radio frequency antenna is configured to induce a radio frequency magnetic field in the sample chamber at a predetermined frequency and a predetermines bandwidth. The static magnetic field amplitude at a sample chamber boundary has substantially at most two values.

An NMR probe head with an MAS stator (1) supplied with microwave radiation from a microwave guide (9) through an opening in a coil block (2) has a microwave lens (6) and a microwave mirror (8a) on an inner side of the MAS stator. The MAS rotor (3) is surrounded by a solenoid RF coil (5) and the microwave lens is arranged and embodied in the opening of the coil block on the side facing a sample volume (4) such that the cylinder axis of the MAS rotor lies in the focus of the microwave lens. The microwave mirror is arranged on, or in, the inner wall of the MAS stator that lies opposite the microwave guide and has a cylindrical and concave structure, such that the microwave mirror focuses the microwave radiation incident from the sample volume onto the central axis of the MAS rotor.

A device and method is described to parallelize a pressure-volume-temperature (PVT) analysis using gas chromatography and mass spectrometry techniques such that a portion of the pressure, temperature and volume analysis is performed separately from others. The resulting PVT data is then recombined statistically for a complete PVT analysis. The device may also obtain compositional data of the fluid to perform an equation of state analysis or reservoir simulations.

A microfluidic device and method is described to parallelize a pressure-volume-temperature (PVT) analysis such that a portion of the pressure, temperature and volume analysis is performed separately from others. The resulting PVT data is then recombined statistically for a complete PVT analysis. The microfluidic device may also obtain compositional data of the fluid to perform an equation of state analysis or reservoir simulations.

A magnetic field monitoring system can include a host system that generates a magnetic field. The magnetic field monitoring system can include a plurality of sensor assemblies disposed apart from each other within the host system. Each of the plurality of sensor assemblies can include a coil wound around a sample and an integrated circuit coupled with the coil. The integrated circuit can perform one or more MR measurements of the sample using one or more pulse sequences.

This polarization-transfer apparatus, which induces hyperpolarization with respect to a precursor containing .sup.13C nuclei or .sup.15N nuclei, has a microfluidic device in which the precursor is guided in a magnetic shield such that the strength of the magnetic field acting on the precursor monotonically decreases from approximately 1 ?T to zero magnetic field, and then the precursor is guided in the magnetic shield such that the strength of the magnetic field acting on the precursor monotonically increases from zero magnetic field to approximately 1 ?T.

An MAS stator (7) for an NMR-MAS probe head (1) has a bottom bearing (8) with at least one nozzle and at least one radial bearing (9a, 9b), wherein one substantially circular cylindrical MAS rotor (21c) is provided for receiving a measurement substance. The MAS rotor can be supported by compressed gas in a measurement position within the MAS stator by means of a gas supply device and can be rotated about the cylinder axis of the MAS rotor by means of a pneumatic drive. A suction device (100) is provided in a space below the radial bearing for suctioning-off the gas introduced by the gas supply device, and generates an underpressure in the space below the radial bearing during measurement operation. This provides a stator for NMR-MAS spectroscopy in which the closure at the head end of the stator is omitted.