Among the various aspects of the present disclosure is the provision of systems and spherical rotors suitable for use in magic angle spinning (MAS) nuclear magnetic resonance (NMR) spectroscopy and methods of use thereof.

The present disclosure relates to a radio frequency (RF) functional probe for testing an RF device in a cryogenic environment. The RF functional probe includes a probe head configured to receive the RF device, a flange structure, an isolation structure coupled between the probe head and the flange structure, and an RF cable structure extending from the flange structure, through the isolation structure, and to the probe head. The isolation structure is configured to provide thermal and electrical isolation to reduce radiant heat leak from the RF cable structure to the RF device. Herein, the isolation structure includes multiple baffle structures, each of which includes cable guides. The cable guides of each baffle structure are configured to guide routing paths for the RF cable structure. The RF cable structure is configured to transmit signals to and from the RF device.

A method is provided for cleaning a reusable fluid path system for hyperpolarization of a pharmaceutical product, the system being continuously at least partly contained by a polarizer. The steps include: providing the polarizer with an inlet tube having a first inlet tube end for fluid contact with a fluid vessel and a second inlet tube end for fluid contact with a vial, for holding the pharmaceutical product; providing the polarizer with an outlet tube having a first outlet tube end for receiving the vial and a second outlet tube end for connecting to a receiving vessel; sealing the second inlet end with the first outlet end; fluidly connecting a medium vessel to the first inlet end; fluidly connecting a collector vessel to the second outlet end; cleaning the path system by transferring cleaning medium from the vessel into the system; ejecting the cleaning medium; and drying the path system.

Chemical-shift nuclear magnetic resonance (NMR) spectroscopy involves measuring the effects of chemical bonds in a sample on the resonance frequencies of nuclear spins in the sample. Applying a magnetic field to the sample causes the sample nuclei to emit alternating current magnetic fields that can be detected with color centers, which can act as very sensitive magnetometers. Cryogenically cooling the sample increases the sample's polarization, which in turn enhances the NMR signal strength, making it possible to detect net nuclear spins for very small samples. Flash-heating the sample or subjecting it to a magic-angle-spinning magnetic field (instead of a static magnetic field) eliminates built-in magnetic field inhomogeneities, improving measurement sensitivity without degrading the sample polarization. Tens to hundreds of small, cryogenically cooled sample chambers can be integrated in a semiconductor substrate interlaced with waveguides that contain color centers for optically detected magnetic resonance measurements of the samples' chemical-shift NMR frequencies.

Chemical-shift nuclear magnetic resonance (NMR) spectroscopy involves measuring the effects of chemical bonds in a sample on the resonance frequencies of nuclear spins in the sample. Applying a magnetic field to the sample causes the sample nuclei to emit alternating current magnetic fields that can be detected with color centers, which can act as very sensitive magnetometers. Cryogenically cooling the sample increases the sample's polarization, which in turn enhances the NMR signal strength, making it possible to detect net nuclear spins for very small samples. Flash-heating the sample or subjecting it to a magic-angle-spinning magnetic field (instead of a static magnetic field) eliminates built-in magnetic field inhomogeneities, improving measurement sensitivity without degrading the sample polarization. Tens to hundreds of small, cryogenically cooled sample chambers can be integrated in a semiconductor substrate interlaced with waveguides that contain color centers for optically detected magnetic resonance measurements of the samples' chemical-shift NMR frequencies.

An MAS probehead (1) positioned in a magnet bore (2) includes a sample chamber (3) with a stator (4) for receiving a rotor and an RF coil that radiates RF pulses into and/or receives RF signals from an NMR sample (5). A temperature-control apparatus guides gas at a first variable temperature T.sub.1 into the sample chamber and through the stator during an NMR measurement, and guides a pressurized gas stream at a second variable temperature T.sub.2 around the sample chamber. The sample chamber is surrounded by an encapsulation device (6), at least in the azimuthal direction around the axis of the magnet bore and counter to the flow direction of the pressurized gas, and is oriented to provide an air gap (7′) between the sample chamber and the magnet bore. This prevents dissipation of the gas temperature to outer parts of the probehead, and yields larger NMR measurement temperature ranges.

An MAS probehead (1) positioned in a magnet bore (2) includes a sample chamber (3) with a stator (4) for receiving a rotor and an RF coil that radiates RF pulses into and/or receives RF signals from an NMR sample (5). A temperature-control apparatus guides gas at a first variable temperature T.sub.1 into the sample chamber and through the stator during an NMR measurement, and guides a pressurized gas stream at a second variable temperature T.sub.2 around the sample chamber. The sample chamber is surrounded by an encapsulation device (6), at least in the azimuthal direction around the axis of the magnet bore and counter to the flow direction of the pressurized gas, and is oriented to provide an air gap (7′) between the sample chamber and the magnet bore. This prevents dissipation of the gas temperature to outer parts of the probehead, and yields larger NMR measurement temperature ranges.

A sensor test system having excellent throughput is provided. The sensor test system 1 includes a test apparatus group 20 including a plurality of sensor test apparatuses 30A to 30D coupled to each other so that the sensor 90 can be transferred, and each of the sensor test apparatuses 30A to 30D includes an application unit 40 including an application device 42 including a socket 445 to which the sensor 90 is electrically connected, and a pressure chamber 43 which applies a pressure to the sensor 90, a test unit 35 which tests the sensor 90 via the socket 445, and a conveying robot 33 which conveys the sensor 90 into and out of the application unit 40.

A sensor test system having excellent throughput is provided. The sensor test system 1 includes a test apparatus group 20 including a plurality of sensor test apparatuses 30A to 30D coupled to each other so that the sensor 90 can be transferred, and each of the sensor test apparatuses 30A to 30D includes an application unit 40 including an application device 42 including a socket 445 to which the sensor 90 is electrically connected, and a pressure chamber 43 which applies a pressure to the sensor 90, a test unit 35 which tests the sensor 90 via the socket 445, and a conveying robot 33 which conveys the sensor 90 into and out of the application unit 40.

A pediatric magnetic resonance (MRI) system and sub-system are provided. The pediatric MRI system includes a magnet-gradient assembly, an RF shield-body coil assembly and a pediatric MRI sub-system. The pediatric MRI sub-system includes an infant warmer or isolette having a patient section for accommodating a patient. The infant warmer is positionable relative to the magnet-gradient-body coil assembly of the pediatric MRI system. The pediatric MRI sub-system also includes a warming mattress arranged within the patient section of the infant warmer. The infant warming mattress includes an interior space filled at least partially with a host medium and a conduction heating system at least partially arranged in the interior space to conduct heat to the interior space of the infant warming mattress. The pediatric MRI system also includes at least one local radio frequency (RF) coil that is positionable within the patient section of the infant warmer.