A coaxial nuclear magnetic resonance (NMR) probe and related methods are described herein. The coaxial NMR probe includes a housing with a fluid inlet, a fluid outlet, a longitudinal axis, and an interior volume. The housing contains a fluid sample that is analyzed by the probe. The coaxial NMR probe also includes an elongated conductor disposed along the longitudinal axis of the housing. The elongated conductor generates an oscillating electromagnetic field within the interior volume of the housing. The oscillating electromagnetic field produces a NMR signal within the fluid sample. The elongated conductor may also be used to receive this NMR signal. The NMR signal is then analyzed to determine information about the fluid sample. Various NMR pulse sequences for use with this coaxial probe and other coaxial probes are also described herein.

Techniques for crushing unwanted coherence pathways during magnetic resonance spectral (MRS) measurements include receiving first data that indicates a sequence of RF pulses with one or more target coherence pathways of spin states for a subject that has at least N1 coupled spin states of interest. A negative, non-integer amplitude is determined for at least one intervening crusher pulse emitted from at least one spatial gradient magnetic coil. The at least one intervening crusher pulse has a duration less than a time between successive pulses of the sequence of RF pulses; and, the intervening crusher pulse de-phases unwanted coherence pathways. A MRS device is operated using the intervening crusher pulse and the sequence of RF pulses.

A system and method for detecting a nucleus of interest in a chemical using a nuclear quadrupole resonance transition. An excitation pulse is used to excite one or more nuclei of interest, if they present in a sample, to an excited state, the energy of which depends on the magnetic field in the sample. The magnetic field in the sample is modulated, after the end of the excitation pulse, while the nuclei of interest decay from the excited state, so that the radiation they emit is frequency modulated. The frequency modulation is detected in the emitted radiation. In some embodiments a DC magnetic field is applied to the sample, during the application of the excitation pulse, to tune the frequency of the transition being excited.

A system and method of acquiring an image at a magnetic resonance imaging (MRI) system is provided. Accordingly, an analog signal based on a pulse sequence and a first gain is obtained. The analog signal is converted into a digitized signal. A potential quantization error is detected in the digitized signal based on a boundary. When the detection is affirmative, a replacement analog signal based on the pulse sequence is received. At least one portion of the replacement analog signal can be based on an adjusted gain. The adjusted gain is a factor of the first gain. The replacement analog signal is digitized into a replacement digitized signal. At least one portion of the replacement digitized signal corresponding to the at least one portion of the replacement analog signal is adjusted based on a reversal of the factor.

In a radio frequency (RF) coil for a magnetic resonance imaging (MRI) system, the RF coil includes loops that are radially arranged. At least some areas of each of the loops overlap each other at a central portion of a radial structure formed by the loops.

Procedure instruction sequences (P.sub.1P.sub.N) in an instruction sequence (for example, an instruction sequence for an NMR spectrometer) are generated in a precedential manner, and transferred to a procedure storage area on a transmission and reception unit in a precedential manner. After the precedential transfer, a remaining portion of the instruction sequence (streaming instruction sequence (S.sub.M1, . . . )) is sequentially generated in predetermined units from the beginning, and sequentially transferred to a FIFO area on the transmission and reception unit. A sequencer refers to the streaming instruction sequence, executes the instruction, and refers to a procedure instruction sequence on the procedure storage area.

A system and method of acquiring an image at a magnetic resonance imaging (MRI) system is provided. Accordingly, an analog signal based on a pulse sequence and a first gain is obtained. The analog signal is converted into a digitized signal. A potential quantization error is detected in the digitized signal based on a boundary. When the detection is affirmative, a replacement analog signal based on the pulse sequence is received. At least one portion of the replacement analog signal can be based on an adjusted gain. The adjusted gain is a factor of the first gain. The replacement analog signal is digitized into a replacement digitized signal. At least one portion of the replacement digitized signal corresponding to the at least one portion of the replacement analog signal is adjusted based on a reversal of the factor.

A method uses the nuclear spin singlet of three hydrogen atoms on the dopamine benzene ring to achieve selective detection of dopamine signals in a complicated system. The present invention is based on magnetic resonance technology to detect dopamine, has good accuracy, sensitivity and selectivity, can accurately detect the signal of dopamine from the complicated system, and the interference of signals of other substances are well eliminated. Meanwhile, the present invention further has the advantages of simple operation and non-intervention, can be used for monitoring the content and distribution of the dopamine in a living body, and has important application value in the fields of biology and medicine.

A method for preparing an NMR material, comprising generating parahydrogen in gas or liquid form at a first location; transporting the parahydrogen away from the first location; mixing a precursor compound including a metabolite component with a catalyst for hydrogenation; hydrogenating the precursor compound using the parahydrogen; transferring polarization in the precursor compound to a nuclear spin of the metabolite component; cleaving a side arm of the precursor compound in a chemical reaction, with the metabolite molecule being one of the products of the reaction; separating the metabolite molecule from the catalyst for hydrogenation and other products of the reaction; and generating metabolite molecules for use in an MRI scanner by extracting a sample of the metabolite molecule having at least 5% polarization.

In one aspect, the disclosure relates to hyperpolarized target molecules and contrast agents comprising the same, methods of making the same, and methods of imaging using same. In a further aspect, imaging performed using the hyperpolarized target molecules and contrast agent can enable real time monitoring and diagnosis of diseases including various cancers and metabolic disorders. The methods are cryogen-free and inexpensive and can be performed in a short time. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.