In an embodiment of the invention inductive coupling of an idler coil to a parent coil is used to provide a double resonance circuit without the disadvantages of capacitive coupling to the parent coil. In an embodiment of the invention, an inductive coupling coil can be used to achieve a double-tuned circuit. In an embodiment of the invention, a circuit uses inductive coupling to achieve a double resonance circuit for .sup.1H, .sup.19F, and .sup.13C experiments where one of the three nuclei are observed and the other two are decoupled. In an embodiment of the invention a pivot or a shunt can be used to couple and decouple the idler coil and the parent coil.

A system and method for detecting a nucleus of interest in a chemical using a nuclear quadrupole resonance transition. An excitation pulse is used to excite one or more nuclei of interest, if they present in a sample, to an excited state, the energy of which depends on the magnetic field in the sample. The magnetic field in the sample is modulated, after the end of the excitation pulse, while the nuclei of interest decay from the excited state, so that the radiation they emit is frequency modulated. The frequency modulation is detected in the emitted radiation. In some embodiments a DC magnetic field is applied to the sample, during the application of the excitation pulse, to tune the frequency of the transition being excited.

Embodiments can provide a method for multi-banded RF-pulse enhanced magnetization imaging, the method comprising determining, by a processor, a frequency offset against a central frequency by specifying an offset frequency for one or more RF coils close to a frequency peak of mobile water; and simultaneously applying, by one or more RF coils, one or more bands of Gaussian RF pulses around the central frequency to a patient from a medical imaging device; wherein the one or more bands of Gaussian RF pulses are symmetrically applied having a distance from the central frequency equal to the frequency offset.

A method to detect transient binding of a substrate molecule of interest in solution to a molecular target includes selecting the substrate molecule of interest and the molecular target such that the substrate molecule of interest can transiently bind to the molecular target; placing one of a sample or a subject of interest in a magnetic resonance (MR) apparatus, the sample or the subject of interest containing the substrate molecule of interest so as to be in contact with the molecular target; providing magnetic labelling of non-exchangeable or slowly exchangeable MR sensitive nuclei of the substrate molecule of interest; receiving an MR signal from the MR sensitive nuclei of the solvent molecules using the MR apparatus; and analyzing the MR signal to obtain a quantity associated with the transient binding of the substrate molecule of interest to the molecular target.

The present invention relate to a system and associate method of MRI and MR spectroscopy which provide stable measurements of the relaxation times, T1 and T2, by using tailored multi-band RF pulses that direct control of the saturation conditions in the background pool of macro-molecular protons, and hence provide a flexible means to induce constant Magnetisation Transfer (MT) effects. In doing this, equal saturation of the background pool is obtained for all measurements independent of the parameters that may be changed, for example, the rotation rate used to obtain a desired flip angle, that is, the degree of change in the magnetisation of the free pool of protons.

Magnetic resonance imaging (MRI) systems and methods using adiabatic tip-down and matched adiabatic flip-back pulses are disclosed. According to an aspect, a system includes a signal generator configured to generate a pulse sequence for on-resonance magnetization transfer preparation. The pulse sequence includes an adiabatic tip-down pulse and a matched adiabatic flip-back pulse for separating spins in a mobile spin pool from spins in a bound spin pool of an anatomical region of interest for imaging. The system includes radio frequency (RF) coils configured to transmit RF pulses in response to the pulse sequence and to acquire RF data in response to transmission of the RF pulses. Further, the system includes a processing system configured to process the RF data to provide a display image indicating different tissue types with discrimination.

A method for detection and quantification of individual analytes in liquid analyte mixtures, by means of NMR spectrometry, in which method a sample of the analyte mixture has a high-frequency pulse applied to it in an NMR spectrometer, and the resulting NMR spectrum is evaluated, is to be developed further in such a manner that it allows a precise analysis of liquid analyte mixtures even when using low-field NMR spectrometers. For this purpose, the sample of the analyte mixture is placed into a low-field NMR spectrometer, and at least one high-frequency pulse that excites only one specific analyte is applied to it.

The present disclosure provides a method for ultrafastly obtaining a two-dimensional J-resolved NMR spectrum with a high-resolution against an inhomogeneous magnetic field. The method utilizes the selective excitation module and the reunion sampling module jointly, which breaks through the limitations of existing methods for obtaining the two-dimensional J-resolved NMR spectrum and effectively eliminates an influence of the inhomogeneous magnetic field along an encoding direction. At the same time, an inhomogeneous magnetic field along x and y directions is theoretically eliminated by a slow rotation of the sample. As a consequence, a two-dimensional J-resolved NMR spectrum with a high resolution is obtained by a single-scanning sampling under the inhomogeneous magnetic field, thus significantly shortening experimental duration and expanding application fields of the two-dimensional J-resolved NMR spectrum. The present disclosure further provides a method using multi-band sampling, which is used to obtain J-resolved NMR spectrum with improved signal-to-noise ratio.

A method for performing magnetic resonance imaging is provided. The method includes providing a magnetic resonance imaging system comprising: a radio frequency receive system comprising a radio frequency receive coil, and a housing, wherein the housing comprises a permanent magnet for providing an inhomogeneous permanent gradient field, a radio frequency transmit system, and a single-sided gradient coil set. The method also includes placing the receive coil proximate a target subject; applying a sequence of chirped pulses via the transmit system; applying a multi-slice excitation along the inhomogeneous permanent gradient field; applying a plurality of gradient pulses via the gradient coil set orthogonal to the inhomogeneous permanent gradient field; acquiring a signal of the target subject via the receive system, wherein the signal comprises at least two chirped pulses; and forming a magnetic resonance image of the target subject.

An imaging method may include obtaining imaging data associated with a region of interest (ROI) of an object. The imaging data may correspond to a plurality of time-series images of the ROI. The imaging method may also include determining, based on the imaging data, a data set including a spatial basis and one or more temporal bases. The spatial basis may include spatial information of the imaging data. The one or more temporal bases may include temporal information of the imaging data. The imaging method may also include storing, in a storage medium, the spatial basis and the one or more temporal bases.