A phantom calibration body (110) for a method for determining at least one quantitative diffusion parameter extracted for characterization of a tissue being suspicious to a tumorous modification in magnetic resonance imaging is disclosed, wherein the phantom calibration body (110) is designed for being characterized during characterization of the tissue by the magnetic resonance imaging. Herein, the phantom calibration body (110) comprises a first compartment (112) having a first cross-section, the first compartment (112) being filled with a first solution comprising a calibration substance having a first concentration; and a second compartment (114) having a second cross-section, the second cross-section having at least two different partitions with differing diameters, wherein the second compartment (114) is filled with a second solution comprising the calibration substance having a second concentration, the second concentration differing from the first concentration. The present invention allows determining absolute quantitative parameters in an individualized fashion for each individual tissue independent from various times of recording, applied software algorithms for post-processing of the raw MRI data, MR devices, or MR vendors. The present invention, thus, allows using the absolute quantitative data extracted from the phantom calibration body (110) measured with every tissue for comparability of quantitative data, being a prerequisite for introducing quantitative diffusion weighted imaging (DWI) into clinical routine.

During a focused-ultrasound or other non-invasive procedure, regions of change within a target region are monitored, and images of the target region are updated with partial images encompassing only the regions of change.

A method includes decomposing, for each of a plurality of orthogonal slices, a set of PRF baseline images for the orthogonal slice into a set of baseline image features for the orthogonal slice; acquiring, using a magnetic imaging resonance (MRI) scanner of a MRI system based on a RF excitation pulse sequence for each of the plurality of orthogonal slices, a combined multi-encoded PRF treatment image; subtracting a weighted sum of the sets of baseline image features from the combined multi-encoded PRF treatment image to obtain a combined treatment-specific temperature information of the imaging region that provides multi-orthogonal slice temperature information associated with or resulting from treatment or thermal ablation of the imaging region of the patient after subtraction or removal of the baseline image features; and processing the combined treatment-specific temperature information to obtain slice-specific treatment-specific temperature information for each of the plurality of orthogonal slices.

The present disclosure provides a method for determining an ultrasound focus location in a thermal image. In one aspect, the method includes obtaining a magnetic resonance thermal image of a tissue heated by a focused ultrasound and correcting a chemical shift and a k-space shift of a monitored ultrasound focus location in the magnetic resonance thermal image such that the monitored ultrasound focus location is aligned with a real physical ultrasound focus location. Correcting the chemical shift includes correcting a first spatial error of the monitored ultrasound focus location caused by resonance frequency changes of hydrogen nuclei due to environmental differences of water molecules. Correcting the k-space shift includes correcting a second spatial error of the monitored ultrasound focus location caused by temperature error due to spatial variations of a primary magnetic field.

The present disclosure describes methods and systems, including computer-implemented methods, computer program products, and computer systems, for measuring wettability of a rock sample. One method includes: at each temperature of a plurality of temperatures, obtaining a first Nuclear Magnetic Resonance (NMR) surface relaxation time for a rock sample having a saturation level; determining a first temperature sensitivity based on the first NMR surface relaxation times and corresponding temperatures; at each temperature of the plurality of temperatures, obtaining a second NMR surface relaxation time for the rock sample that is saturated with oil; determining a second temperature sensitivity based on the second NMR surface relaxation times and corresponding temperature; and determining a wettability of the rock sample based on the first temperature sensitivity and the second temperature sensitivity.

In some embodiments, the present disclosure pertains to a method of delivery of an active agent to a target tissue, in a subject in need thereof comprising positioning a high intensity focused ultrasound transducer to enable delivery of ultrasound energy to the target tissue. Such a method comprises energizing the high intensity focused ultrasound transducer; imaging at least a portion of the target tissue; and discontinuing delivery of ultrasound energy. Further, such a method may comprise administering the active agent to the subject under the conditions of thermal stimulation. In another embodiment, the present disclosure relates to a method of treating a tumor in a subject in need thereof comprising administering a therapeutic agent to the subject and providing thermal stimulation to the tumor. In some embodiments, there is provided a method for increasing the efficacy of a therapeutic agent in a target tissue.

The present disclosure provides, inter alia, a system and methods for targeted hyperthermia effective to differentially heat target organs. In certain embodiments, the system and/or method utilizes one or more pairs of inductive applicators coupled to the one or more RF generators and configured to deposit radio frequency radiation on a region of interest based on a set of configurable parameters.

The present disclosure describes non-invasive approaches for delineating and characterizing tissue using MR imaging over a range of treatment levels. By way of example, tumor tissue may be distinguished and delineated from other tissue, such as muscle tissue. Further, tumor tissue may be characterized as malignant or benign using such approaches.

Provided herein are novel liquid crystal based devices for the facile measurement of temperature in an MRI system. The thermometers comprise a plurality of vessels wherein each vessel contains a liquid crystal composition having a unique phase transition temperature. By scanning with appropriate techniques, the state of the liquid crystals in each vessel can be assessed, and the temperature at the time of the scan can be determined by the state of the liquid crystal compositions. Also provided are novel vessels and assemblies of vessels that can be used as MRI thermometers and which are compatible with MRI phantoms.

A magnetic resonance tomography system has a frequency control device for temperature compensation, a temperature sensor, and a high frequency generator. An output frequency of an output signal from the high frequency generator is dependent on a value of a digital frequency variable, and a synthesis signal with the system frequency is generated dependent on the output signal. A temperature change is detected using the temperature sensor, a temperature-time function of the temperature is determined using the temperature change that has been detected, a time is determined at which a change in the digital frequency variables in the least significant bit brings about a change in the frequency of the synthesis signal that corresponds with a change in the system frequency due to a temperature, according to the interpolated temperature-time function, and the digital frequency variable in the least significant bit is changed at the specified time.