Disclosed herein is a method for multimodal imaging during a medical procedure using magnetic resonance imaging (MRI) and Raman optical imaging which involves administering an MRI imaging contrast agent that a chemical structure having charge-transfer electronic transitions. The tissue is imaged using and MRI device and the tissue is illuminated with excitation light that has spectral components that are approximately tuned close to one of the charge-transfer electronic transitions thereby producing enhanced Raman optical signals which are analyzed to produce Raman imaging data followed by registering the MRI and Raman imaging data. The present disclosure also provides a method for ionizing laser plumes through atmospheric pressure chemical ionization.

A computer implemented method of treatment targeting includes receiving magnetic resonance (MR) images of a subject including a target region, generating at least one contour of at least one surrogate element apart from the target region in the MR images, and determining a location of the target region in each of the MR images based on a location of the at least one contour in the MR images.

A device and a process for performing high temporal- and spatial-resolution MR imaging of the anatomy of a patient during intensity modulated radiation therapy (IMRT) to directly measure and control the highly conformal ionizing radiation dose delivered to the patient for the treatment of diseases caused by proliferative tissue disorders. This invention combines the technologies of open MRI, multileaf-collimator or compensating filter-based IMRT delivery, and cobalt teletherapy into a single co-registered and gantry mounted system.

The present invention relates to a stimulation apparatus (10), comprising a magnetic stimulation unit (20), and a processing unit (30). The processing unit is configured to control the magnetic stimulation unit to provide intentional nerve and/or muscle stimuli to a peripheral body part of a patient.

Embodiments described herein relate to detectors and their method of use for sensing electromagnetic fields, electromagnetic signals, biochemical analytes, and/or other conditions in subjects. The device may include an inductively-coupled implantable coil-based transducer that converts electrical, photonic, biochemical signals, and/or other appropriate signals and/or conditions originating in tissues and/or transplanted tissue grafts into changes in a property of the transducer, such as a resonance frequency, that may be detected using an alternating magnetic field that may be provided by a magnetic resonance imaging (MRI) signal and/or other appropriate source. In some embodiments, the detector comprises a FET that changes state upon detection of a subject condition of interest. The change in the FET may change the resonance frequency of an associated LC or RLC circuit. The change in resonance frequency may change the brightness and/or intensity of the detector when detected by an MRI scanner or other appropriate scanner.

Systems and methods for the delivery of linear accelerator radiotherapy in conjunction with magnetic resonance imaging in which components of a linear accelerator may be placed in shielding containers around a gantry, may be connected with RF waveguides, and may employ various systems and methods for magnetic and radio frequency shielding.

Examples described herein may predict therapy efficacy and/or therapeutic parameters using a comparison of individual patient status data and brain network response maps for the therapy. For example, VNS parameters may be predicted using a comparison of patient EEG data and brain network response maps of VNS therapy at various parameters.

A gradient coil assembly for a magnetic resonance imaging device is disclosed. The gradient coil assembly comprises a cylindrical carrier with conductors forming three gradient coils associated with three orthogonal physical gradient axes. The cylindrical carrier comprises at least two radial through openings at different angular positions. At least one of the conductors runs through at least one area of the carrier located circumferentially between the through openings.

Disclosed is a medical system (100, 500) that comprises a radiotherapy system (102) configured for controllably irradiating a target volume (114) within an irradiation zone (112); a subject support (120) configured for supporting at least a ventral region (124) of a subject (122) within the irradiation zone; a breath monitor system (132, 132′) configured for providing a motion signal (154, 158) descriptive of subject breathing motion; and a subject display (130, 130′) configured for displaying a breathing phase indicator (160, 160′) to the subject when supported by the subject support. Execution of the machine executable instructions (150) causes a processor (142) controlling the medical system to receive (200) a time resolved magnetic resonance imaging dataset (152) synchronized to a measured motion signal (154). Execution of the machine executable instructions further causes the processor to repeatedly: determine (202) a desired motion signal (156) by temporally stepping through the measured motion signal; acquire (204) a current motion signal (158) using the breath monitor system; render (206) the breathing phase indicator on the display, wherein the breathing phase indicator is configured to indicate a difference (700) between the desired motion signal and the measured motion signal; and generate (208) control commands (162) configured for controlling targeting of the radio therapy system using a first portion of the time resolved magnetic resonance imaging dataset synchronized to the desired motion signal or a second portion of the time resolved magnetic resonance imaging dataset referenced by the current motion signal.

The present application relates to a radiotherapy apparatus for delivering radiation to a subject. The apparatus comprises a source of radiation configured to rotate about an isocenter and emit radiation in a radiation plane containing said isocentre. The apparatus also comprises a subject support surface including a portion configured to be located substantially at the isocenter. The subject support surface comprises a subject support surface rotation mechanism configured to rotate the subject support surface about an axis of rotation parallel to and spaced from an axis that passes through the isocenter. The subject support surface also comprises a first section configured to move from a first position to a second position along at least one of a longitudinal and lateral direction. The apparatus also comprises a processor configured to control the longitudinal and/or lateral movement of the first section as a function of the rotation of the subject support surface to maintain the portion of the subject support surface substantially at the isocenter.