Described herein are positron emission tomography (PET)-electron paramagnetic resonance imaging (EPRI) systems and methods of use. In one example, a PET-EPRI system includes a PET-EPR insert, a PET scanner including one or more solid-state photodetectors, and a subject module that can house a subject for scanning. The PET-EPR insert includes an EPR resonator that can nest inside the PET scanner. The EPR resonator includes a resonator that can receive the subject module, a shield encircling the resonator and one or more rapid scan coils (RS-coils) positioned around the shield. The shield can prevent electrical coupling between the RS-coils and the resonator while being transparent to annihilation photons and magnetic field scans.

The multi-modal imaging system, in particular for brain imaging, comprising a pump signal generator which emits at least one pump signal in the radio frequency (RF)-range with a first power P1 and a second power P2, a wireless detection unit, which comprises at least one parametric resonator circuit with multiple resonance modes, wherein the at least one parametric resonator circuit comprises at least two varactors, at least one capacitor and at least one inductance, wherein, in a first detection mode, the pump signal, having a first power P1, induces a first pump current in the at least one parametric resonator circuit, wherein the at least one parametric resonator circuit is operated below its oscillation threshold and generates a first output signal by amplifying a first input signal, which is provided due to a magnetic-resonance (MR) measurement, wherein an external receiving device receives the first output signal, wherein, in a second detection mode, the pump signal, having a second power P2, induces a second pump current in the at least one parametric resonator circuit, wherein the at least one parametric resonator circuit is operated above its oscillation threshold and generates a second output signal, wherein the second output signal is modulated with a second input signal, wherein the second input signal is provided by at least one neuronal probe device, connected to the at least one parametric resonator circuit, wherein the external receiving device receives the second output signal.

The present disclosure relates to a therapeutic apparatus including an MRI apparatus configured to acquire MRI data with respect to a region of interest. The MRI apparatus may include a plurality of main magnetic field coils coaxially arranged along an axis. The MRI apparatus may also include a plurality of shielding coils arranged coaxially along the axis. A current within at least one of the shielding coils may be in the same direction with a current within the main magnetic field coils.

Magnetic resonance (MR) guided radiation therapy (MRgRT) enables control over the delivery of radiation based on patient motion indicated by MR imaging (MRI) images captured during radiation delivery. A method for MRgRT includes: simultaneously using one or more radiation therapy heads to deliver radiation and an MRI system to perform MRI; using a processor to determine whether one or more gates are triggered based on at least a portion of MRI images captured during the delivery of radiation; and in response to determining that one or more gates are triggered based on at least a portion of the MRI images captured during the delivery of radiation, suspending the delivery of radiation.

Provided is a brain measurement system including: a geomagnetic correction coil; a geomagnetic gradient correction coil; a transmission coil; a receiving coil; a plurality of resonance adjustment circuits; a plurality of OPM modules provided corresponding to each of the plurality of resonance adjustment circuits for detecting a signal having a resonance frequency output from the resonance adjustment circuit; and a control device for generating an MR image based on the signal detected by the OPM module, wherein, when a direction parallel to a central axis of a head portion of a subject is defined as a Z-axis direction, the resonance frequency related to each of the plurality of resonance adjustment circuits is set according to a magnetic field gradient in the Z-axis direction generated by control of a position of the corresponding receiving coil in the Z-axis direction and a tilted magnetic field.

A medical imaging system a magnet unit includes a main magnet and a first housing. In an embodiment, the main magnet is arranged inside the first housing and includes coil elements and at least one coil carrier, the magnet unit defining an examination opening. The first radiation unit is embodied to irradiate the examination object and is arranged on the side of the magnet unit. The magnet unit includes a first region, transparent to radiation emitted by the first radiation unit radially to the examination axis. The first radiation unit is embodied to emit radiation through the first region of the magnet unit in a direction of the examination opening and is furthermore embodied to rotate about the examination opening.

The present disclosure is directed to a radiation therapy system. The radiation therapy system may comprise a magnetic resonance imaging (MRI) apparatus configured to acquire MRI data with respect to a region of interest (ROI) of a subject, the MRI apparatus including a magnetic body; and a radiation therapy apparatus configured to apply a radiation beam to at least one portion of the ROI. The radiation therapy apparatus may include a linear accelerator configured to accelerate electrons to produce the radiation beam, the linear accelerator being located in a bore formed by an inner surface of the magnetic body, and a length direction of the linear accelerator being parallel with an axis of the magnetic body.

A system and method is provided for magnetic resonance imaging (MRI) guided respiratory gated radiotherapy using a respiratory motion model. MRI-guided respiratory gating is performed with a continuously updated model that represents a patient's internal anatomy as a mathematical function of an external respiratory surrogate. The motion model may be built and updated by acquiring images of a tissue in a subject and measuring, using the images, a position of the tissue in the images to determine motion of the tissue. The surrogate respiratory signal is acquired contemporaneously with acquiring the images. Motion of the tissue and the surrogate respiratory signal are correlated to create the motion model for the subject and gating a radiotherapy system may then be based upon the motion model. A multi-planar model-based respiratory gating may also be performed by sequentially imaging a stack of adjacent slice positions.

A 3D model of AC electrical conductivity (at a given frequency) of an anatomic volume can be created by obtaining two MRI images of the anatomic volume, where the two images have different repetition times. Then, for each voxel in the anatomic volume, a ratio IR of the intensity of the corresponding voxels in the two MRI images is calculated. This calculated IR is then mapped into a corresponding voxel of a 3D model of AC electrical conductivity at the given frequency. The given frequency is below 1 MHz (e.g., 200 kHz). In some embodiments, the 3D model of AC electrical conductivity at the given frequency is used to determine the positions for the electrodes in TTFields (Tumor Treating Fields) treatment.

A method for postural independent location of targets in diagnostic images acquired by multimodal acquisitions, compensating for deformation of soft tissues due to changing posture, includes generating a transition of a digital image of the inside of a target region from a first to a second position by correlating the position of markers placed on the external surface of the target region in a digital image of the inside of the target region and in a digital representation of the external surface of the target region acquired by optically scanning the external surface; and at a later time registering the diagnostic image of the inside of the target region, transitioned into the second position, with a diagnostic image of the same target region acquired with the target region in the second position by matching a second representation of the external surface of the target region in the second position without markers with the diagnostic image of the inside of the target region transitioned into the second position.