Disclosed herein are synthesis methods for coelenterazine. Also disclosed are articles including the coelenterazine and coelenterazine derivatives. Representative absorbent articles include disposable diapers and adult incontinence products.

An absorbent article comprising a primary indicator and a secondary indicator.

An absorbent article including features facilitating toilet training of a wearer is provided. The article includes at least a first appearing graphic that changes from an initial, less visible state to a subsequent, more visible state in the absence of wetness, thereby to provide positive encouragement to a child during toilet training. The appearing graphic becomes less visible if subjected to liquid. A wetness sensation member may also be provided to give tactile, negative sensation to the child, thereby giving feedback received by at least two different senses. Additionally or alternatively, a second appearing graphic, different from the first appearing graphic, may be provided to increase a child's interest in the toilet training process. The first and second appearing graphics may become visible at different times, thereby providing a sequential or spaced reveal of the image.

An absorbent article comprising an absorbent core having at least two longitudinally extending channel-forming areas and a wetness indicator. The core wrap comprises a top side and a bottom side, which are attached to each other through areas substantially free of absorbent material, so that when the absorbent material swells upon absorption of a liquid the core wrap forms channels along these areas substantially free of absorbent material.

Disclosed are systems and methods of a health monitoring device comprising: a flexible circuit, an absorbent product, and, a processing unit. The flexible circuit comprises: an electrochemical biosensor, a color sensor, an LED, and, a moisture sensor. The electrochemical biosensor comprises a plurality of reference electrodes. The processing unit comprises: a GPS antenna, a power unit, a BLUETOOTH? low energy transceiver, a GPS transceiver, a microcontroller, and, an accelerometer. The processing unit is electronically coupled to the flexible circuit. The methods comprise: obtaining health data from health monitoring device; recording the health data on the memory unit; transmitting the health data to a data communication device; and, displaying the health data on the data communication device.

An environmentally friendly cloth diaper having an interchangeable wetness indicator is provided. The environmentally friendly cloth diaper includes a covering body and at least one wetness indicator. The covering body has an inner side layer, an outer side layer, and an absorption layer. The wetness indicator is interchangeably disposed on the covering body and is exposed from the outer side layer of the covering body, and urine absorbed in the absorption layer is able to be transported to the wetness indicator so that the color of the wetness indicator is changed.

A feminine care absorbent article (e.g., feminine care pad, sanitary napkin, incontinence article, pantiliner, etc.) that employs a color changing indicator graphic for signaling to the wearer an appropriate time to remove and/or replace the feminine care absorbent article following a liquid insult. This can be particularly useful in warm environments in which a wearer may secrete a significant amount of perspiration which may act as a carrier for microorganisms. In this manner, the wearer can wear the article without fear of a bacterial infection and/or the generation of an odor. After a time period of usage, the wearer can visually inspect the color of the color changing indicator graphic for an indication of whether it is time to remove and/or replace the feminine care absorbent article.

Described herein are a wearable apparatus and methods for detecting the presence of a targeted substance in a liquid. For example, the wearable apparatus can be a fingernail that detects illicit drugs in a beverage. The wearable apparatus comprises a detection layer comprising an indicator that is configured to display a signal upon the detection of an interaction with the targeted substance. In some examples, the wearable apparatus can include a lateral flow assay.

Described herein are apparatus and methods for detecting substances of abuse or other analytes in liquids. For example, the apparatus and methods described herein can be used for real-time detection of analytes, such as substances of abuse. The methods comprise providing a detection area comprising a chromatographic membrane capable of receiving the liquid and allowing for migration of the liquid, the chromatographic membrane comprising an anti-analyte antibody-particle conjugate, an analyte-conjugate protein at a test line; exposing at least the first location of the apparatus to the liquid; and determining whether an interaction between the analyte-conjugate protein and the liquid occurs to detect the presence of the analyte. The chromatographic membrane may further comprise an anti-species antibody at a control line. Specific buffers are disclosed, and these buffers may be used in the preparation of the apparatus to overcome challenges associated with miniaturization and challenges associated with exposure to beverages.

An underpants-type disposable diaper includes outer members 12F and 12B having stretchable regions A2 and A3 disposed adjacent to the inner edges of the side seal portions 12A in the width direction. The stretchable regions A2 and A3 include multiple elongated elastically stretchable members 19 disposed between two sheet layers 12S and 12H at predetermined intervals in the front-back direction and extending in the width direction. The elastically stretchable members 19 each include two fixed ends 19f fixed to the two sheet layers 12S and 12H, and the section between the fixed ends 19f is unfixed to the two sheet layers 12S and 12H. The two sheet layers 12S and 12H are welded into sheet bonding sections 20, at positions between the elastically stretchable members 19 in the stretchable regions A2 and A3 adjacent is the front-back direction. No sheet bonding section protrudes from the side seal portion in the stretchable regions A2 and A3.