Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The integrated devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The arrays and methods of the invention make use of silicon chip fabrication and manufacturing techniques developed for the electronics industry and highly suited for miniaturization and high throughput.

An optical fiber having a Bragg grating along a non-photosensitized grating region thereof and a pristine polymer coating around the grating region with the Bragg grating having been written through the polymer coating has a mechanical resistance that is greater than 20% of the mechanical resistance of an identical grating-free optical fiber.

A manufacturing device of an optical fiber grating to write a grating in a core of an optical fiber by irradiating the optical fiber with laser light includes: a fixing device that fixes the optical fiber to at least one of a first position located more on an upstream side and a second position located more on a downstream side in a conveyance direction of the optical fiber than a laser light irradiating position of the optical fiber in a case of writing the grating; and a feeder having a structure capable of linearly reciprocating in the conveyance direction and adapted to feed a predetermined length of the optical fiber in the conveyance direction in a case where a fixed state of the optical fiber by the fixing device is released.

Disclosed herein is an optical fiber having an optically uniform coating having no physical defects in the coating greater than 100 micrometers in size over a length of 50 meters or greater.

The disclosed embodiments generally relate to extruding multiple layers of micro- to nano-polymer layers in a tubular shape. In particular, the aspects of the disclosed embodiments are directed to a method for producing a Bragg reflector comprising co-extrusion of micro- to nano-polymer layers in a tubular shape.

Methods and systems for writing a Bragg grating along a grating region of an optical fiber through a polymer coating of the optical fiber are provided. A light beam of ultrafast optical pulses is impinged on the grating region, the ultrafast optical pulses being characterized by writing wavelength at the grating region to which the polymer coating is substantially transparent The light beam is diffracted through a phase mask so as to form an interference pattern defining the Bragg grating at the grating region of the optical fiber. The light beam is also focussed such that the intensity of the optical pulses is below a damage threshold within the polymer coating, and above an FBG inscription threshold within the grating region of the fiber. Optical fiber having Bragg gratings and improved mechanical are also provided.

A method for forming a pressure sensor is provided wherein an optical fibre is provided, the optical fibre comprising a core, a cladding surrounding the core, and a birefringence structure for inducing birefringence in the core. The birefringence structure comprises first and second holes enclosed within the cladding and extending parallel to the core. A portion of the optical fibre comprising the core and the birefringence structure is encased within a chamber, wherein the chamber is defined by a housing comprising a pressure transfer element for equalising pressure between the inside and the outside of the housing. An optical sensor is provided along the core of the optical fibre. Providing the optical sensor comprises optically inducing stress in the core so that the optical sensor exhibits intrinsic birefringence. The chamber is filled with a substantially non-compressible fluid. Consequently, the birefringence structure is shaped so as to convert an external pressure provided by the non-compressible fluid within the chamber to an anisotropic stress in the optical sensor.

Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The integrated devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The arrays and methods of the invention make use of silicon chip fabrication and manufacturing techniques developed for the electronics industry and highly suited for miniaturization and high throughput.

Disclosed are various embodiments for high diffraction efficiency phase gratings. An organized set of nanoparticles are embedded within a polymer composite. The polymer composite is then etched to generate one or more trenches in the polymer composite that correspond to the organized set of nanoparticles.

The disclosed embodiments generally relate to extruding multiple layers of micro- to nano-polymer layers in a tubular shape. In particular, the aspects of the disclosed embodiments are directed to a method for producing a Bragg reflector comprising co-extrusion of micro- to nano-polymer layers in a tubular shape.