A disposable wearable article including a top sheet having a skin-touching region that is brought into contact with skin of a wearer, the top sheet being made from nonwoven fabric, wherein the skin-touching region has a lotion-bearing zone which bears a hydrophilic lotion containing water and glycerin, the lotion-bearing zone having a MD dimension of 30 mm or larger and a CD dimension of 5 mm or larger, wherein the lotion-bearing zone has a surface moisture percentage of 3 to 10%, wherein the hydrophilic lotion has a water activity value of 0.8 or less, and wherein the hydrophilic lotion is free of preservatives.

A dressing for treating a tissue site with negative pressure may comprise a cover having an adhesive, a manifold, a perforated polymer film, and a perforated silicone gel having a treatment aperture. The cover, the manifold, the perforated polymer film, and the perforated silicone gel may be assembled in a stacked relationship with the cover and the perforated silicone gel enclosing the manifold. The perforated polymer film may be at least partially exposed through the treatment aperture, and at least some of the adhesive may be exposed through the perforated silicone around the treatment aperture.

Disposable absorbent articles are disclosed herein having a first and second fold line. The disposable absorbent articles have a topsheet, a backsheet, and an absorbent system disposed therebetween. The absorbent system has a first absorbent core and a second absorbent core which may be configured in an offset manner. And, the absorbent system and/or the first and second fold lines may be configured with respect to the absorbent article to effect a caliper change in the folded article.

Disposable absorbent articles are disclosed herein having a first and second fold line. The disposable absorbent articles have a topsheet, a backsheet, and an absorbent system disposed therebetween. The absorbent system has a first absorbent core and a second absorbent core which may be configured in an offset manner. And, the absorbent system and/or the first and second fold lines may be configured with respect to the absorbent article to effect a caliper change in the folded article.

An absorbent article which can have an improved vertical absorption capability in the depth direction of the absorbent article. The absorbent article can have a topsheet layer, a backsheet layer, and an absorbent system positioned between the topsheet layer and the backsheet layer. The absorbent system can have at least a fluid intake layer and an absorbent core. The fluid intake layer can provide the absorbent article with a raised portion which can improve the vertical absorption capability in the depth direction of the absorbent article.

Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a HBV and/or HDV and/or HIV infection with one or more nucleotide analogs.

Provided are a composite sheet whose recess-protrusion shape can easily be made crush-resistant in a state that the soft feel against the skin is maintained, and a device and method for manufacturing said composite sheet. A first sheet has a curved part in which one surface thereof rises and the other surface thereof is recessed, and a boundary part adjacent to the curved part. A second sheet is joined to the boundary part of the first sheet so as to cover the other surface of the curved part. A region of the second sheet facing the curved part has a protruding part in which an inside surface on the first sheet side rises so as to approach the curved part and an outside surface on the reverse side thereof is recessed, and a flat part surrounding the periphery of the protruding part.

Provided are a composite sheet whose recess-protrusion shape can easily be made crush-resistant in a state that the soft feel against the skin is maintained, and a device and method for manufacturing said composite sheet. A first sheet has a curved part in which one surface thereof rises and the other surface thereof is recessed, and a boundary part adjacent to the curved part. A second sheet is joined to the boundary part of the first sheet so as to cover the other surface of the curved part. A region of the second sheet facing the curved part has a protruding part in which an inside surface on the first sheet side rises so as to approach the curved part and an outside surface on the reverse side thereof is recessed, and a flat part surrounding the periphery of the protruding part.

A patterned apertured web is disclosed. The patterned apertured web includes a plurality of land areas in the patterned apertured web and a plurality of apertures defined in the patterned apertured web. At least some land areas of the plurality of land areas surround at least some apertures of the plurality of apertures. The patterned apertured web has an Effective Open Area in the range of about 3% to about 30%, according to the Aperture Test herein. The plurality of apertures include a first set of apertures defining a first shape and a second set of apertures defining a second shape. The first shape is positioned within the second shape.

A patterned apertured web is disclosed. The patterned apertured web includes a plurality of land areas in the patterned apertured web and a plurality of apertures defined in the patterned apertured web. At least some land areas of the plurality of land areas surround at least some apertures of the plurality of apertures. The patterned apertured web has an Effective Open Area in the range of about 3% to about 30%, according to the Aperture Test herein. The plurality of apertures include a first set of apertures defining a first shape and a second set of apertures defining a second shape. The first shape is positioned within the second shape.