This invention describes a wound dressing product for active continuous debridement of devitalized tissues in non-healing wounds including diabetic ulcers, pressure ulcers, burn injuries and other etiologies. The present invention pertains to the principle of continuous wound debridement which makes necrotic tissue more susceptible for removal and hence enhances progressive wound healing. The dressing contains an active ingredient, such as collagenase which serves to debride wounds in-situ. In the present invention purified Collagenase (90% pure) was deposited onto several wound dressing materials. A key feature of this invention is that the activity level of the Collagenase used was substantially preserved.

An array of disposable absorbent articles is described herein. The array has a first plurality of absorbent articles and a second plurality of absorbent articles. Each of the first plurality and second plurality of absorbent articles have absorbent cores having patterned end edges each having a plurality of inflection points.

Pulpless absorbent cores and methods of manufacture are disclosed. A method of forming a pulpless absorbent core may comprise moving a foraminous forming surface having un-masked portions and masked portions in a machine direction, the un-masked portions defining an absorbent core region. The method may further comprise depositing particulate material at a velocity of less than 1200 meters per minute in the absorbent core region while applying a vacuum. The absorbent core region may comprise: a front core region spanning a first half of the absorbent core region and a rear core region spanning a second half, wherein the front core region trails the rear core region in the machine direction, and the masked portions of the foraminous forming surface block airflow through the forming surface to cause greater than 60% of the particulate material deposited in the absorbent core region to locate in the front core region.

An absorbent article having improved adhesive attachment means to secure the absorbent article in the crotch region of a garment. The adhesive attachments means of this invention consists of an adhesive exhibiting reduced migration.

A tissue paper product is provided having at least one ultra-low density ply having a highly porous, open-celled structure and that comprises cellulosic fibers, a water insoluble binder and a foaming surfactant. The cellulosic fiber comprises greater than 50% by weight of the ply and are bonded to one another by hydrogen bonding. Further, the ply has a density less than about 0.04 g/cc and yet still provides low lint and high strength properties with the use of minimal binder. The ultra-low density ply may comprise or be included in sheets forming a stack of dispensable wipers or may be employed as or part of an absorbent core or liquid distribution layer of a personal care absorbent personal care product such as a diaper or feminine pad.

An absorbent article. The absorbent article includes a topsheet having a body contacting surface, a backsheet joined to said topsheet, and an absorbent core disposed between the topsheet and the backsheet, wherein the absorbent core has an upper layer and a lower layer. The lower layer has two density zones.

A sanitary absorbent article having a topsheet, a backsheet, an absorbent core comprising a high internal phase emulsion foam disposed between the topsheet and the backsheet, and from about 10 gsm to about 50 gsm of an adhesive attachment means disposed on a garment faceable surface of the backsheet for securing the article to an undergarment. The adhesive attachment means includes between about 0% and about 20% of a low molecular weight component, based on the total weight of the adhesive attachment means, wherein the low molecular weight component has a weight average molecular weight of between about 400 and about 700 Daltons and a kinematic viscosity measured at 40? C. of 68 CST. The adhesive attachment means is a rubber based resin.

Systems, apparatus, and methods are described for delivering a therapeutic substance to the tympanic membrane of an ear of a subject, including a reservoir configured to contain the therapeutic substance and a delivery interface by which the therapeutic substance is delivered to the tympanic membrane.

Pulpless absorbent cores and methods of manufacture are disclosed. A method of forming an absorbent core may comprise moving a forming surface in a machine direction, creating a pressure differential across the forming surface, advancing a base carrier sheet on the forming surface in the machine direction, applying a first adhesive onto the base carrier sheet, and applying a first quantity of particulate material onto the first adhesive at a first cross-machine direction width. The method may further comprise depositing a matrix of material onto the first quantity of particulate material at a second cross-machine direction width, the matrix of material comprising a second quantity of particulate material and a second adhesive, wherein the second cross-machine direction width is smaller than the first cross-machine direction width, and wherein the second quantity of particulate material and the adhesive are pre-mixed prior to deposition onto the first quantity of particulate material.

An absorbent article. The absorbent article includes a topsheet having a body contacting surface, a backsheet joined to said topsheet, and an absorbent core disposed between the topsheet and the backsheet, wherein the absorbent core has an upper layer and a lower layer. The lower layer has two density zones.