Disclosed are an endoscopic reflection microscope using an optical fiber bundle and an image acquisition method using the same. The endoscopic reflection microscope includes an incident wave output unit configured to output an incident wave to a target object through any one optical fiber in an optical fiber bundle, a reflected wave receiver configured to receive a reflected wave output from the target object in response to the incident wave through a plurality of corresponding optical fibers in the optical fiber bundle, and an image acquirer configured to establish a reflection matrix corresponding to the reflected wave and to acquire an image in which at least one of phase retardation of the incident wave or phase retardation of the reflected wave is compensated for based on the established reflection matrix.

Disclosed are a multi-mode thermal imaging device and an operation method thereof. According to an embodiment of the present invention, in a first mode, a first sample is scanned with an optical signal from a light source, signals reflected from the first sample by the scanning are detected separately for each wavelength, a reflectance change spectrum according to the wavelength is derived on the basis of the signals detected separately for each wavelength, a wavelength is selected on the basis of the derived reflectance change spectrum, and a thermal image of the first sample is obtained, through a filter, by detecting an optical signal limited to the selected wavelength from among the signals reflected from the first sample. In a second mode, thermal radiation of a second sample is detected to obtain a thermal image of the second sample.

a) A Gabor domain optical coherence microscopy (GD-OCM) system providing high resolution of structural and motion imaging of objects such as tissues is combined with the use of reverberant shear wave fields (RevSW) or longitudinal shear waves (LSW) and two novel mechanical excitation sources: a coaxial coverslip excitation (CCE) and a multiple pronged excitation (MPE) sources providing structured and controlled mechanical excitation in tissues and leading to accurate derivation of elastographic properties. Alternatively, general optical computed tomography (OCT) is combined with RevSW or LWC in the object to derive elastographic properties. The embodiments include (a) GD-OCM with RevSW; (b) GD-OCM with LSW; (c) General OCT with RevSW; and General OCT with LSW.

Systems and methods for focusing a light pulse within a focus area using nonlinear photoacoustic wavefront shaping (PAWS) are disclosed herein. The method includes modulating a spatial phase pattern of a light pulse's waveform based on a Grueneisen-relaxation photoacoustic (GR-PA) feedback signal. In addition, systems and methods for performing Grueneisen-relaxation photoacoustic microscopy (GR-PAM) are disclosed herein that include analyzing photoacoustic signals resulting from illumination of a focus region by two closely spaced light pulses. A method of obtaining an absorption coefficient of a sample using Grueneisen-relaxation photoacoustic microscopy (GR-PAM) is also disclosed.

An apparatus is described for measuring surface topography of a patient's teeth. The apparatus may include an optical probe, a light source configured to generate incident light, and focusing optics configured to focus the incident light to a focal plane external to the optical probe, wherein the focal plane is a diagonal focal plane that is non-orthogonal to a direction of propagation of the incident light. The apparatus may further include a light sensor configured to measure a characteristic of returned light generated by illuminating the patient's teeth with the incident light, and a processing unit operable to determine the surface topography of the patient's teeth based on the measured characteristic of the returned light.

A spectroscopy system comprising at least two laser modules, each of the laser modules including a laser cavity, a quantum cascade gain chip for amplifying light within the laser cavity, and a tuning element for controlling a wavelength of light generated by the modules. Combining optics are used to combine the light generated by the at least two laser modules into a single beam and a sample detector detects the single beam returning from a sample.

Disclosed are a multi-mode thermal imaging device and an operation method thereof. According to an embodiment of the present invention, in a first mode, a first sample is scanned with an optical signal from a light source, signals reflected from the first sample by the scanning are detected separately for each wavelength, a reflectance change spectrum according to the wavelength is derived on the basis of the signals detected separately for each wavelength, a wavelength is selected on the basis of the derived reflectance change spectrum, and a thermal image of the first sample is obtained, through a filter, by detecting an optical signal limited to the selected wavelength from among the signals reflected from the first sample. In a second mode, thermal radiation of a second sample is detected to obtain a thermal image of the second sample.

A method of analyzing foreign matter in a sample includes: measuring an optical spectrum for each of a plurality of measurement points of a measurement region on the sample by a microscopic spectroscope; calculating a feature value of each measured spectrum by a computer; determining whether each of the measurement points is on the foreign matter or not based on each feature value; retaining the spectrum of the measurement point that is determined to be on the foreign matter, and deleting the spectrum of the measurement point that is not determined to be on the foreign matter or storing the same to a storage unit; and executing multivariate analysis of the spectra of the plurality of the measurement points that are determined to be on the foreign matter or classifying the same with AI search.

A microscopic image acquisition system includes: a microscope apparatus that scans light of multiple wavelengths, transmits the light to an objective lens, and detects a fluorescence signal reflected at a living tissue and transmitted to the objective lens; an endoscope probe including lenses, which is inserted into an implantable device implanted in a living body, transmits an incident light from the objective lens to a side opening at a lower end, and transmits a fluorescence signal emitted from the living tissue labeled with a fluorescent material to the objective lens; and a rotatable probe moving device that fixes the endoscope probe to rotate or vertically move the fixed endoscope probe.

An intraoral scanner includes a light source to generate light that is to be output onto an object external to the intraoral scanner. The intraoral scanner further includes an optical system comprising a projection subsystem and an imaging subsystem that are combined such that projection optics of the projection subsystem and imaging optics of the imaging subsystem share one or more lenses and an optical path, wherein the light is to travel the optical path in a first direction to illuminate the object external to the intraoral scanner, and wherein reflected light that has been reflected off of the object external to the intraoral scanner is to travel the optical path in a second direction that is opposite the first direction. The intraoral scanner further includes an image sensor configured to receive the reflected light that has been reflected off of the object external to the intraoral scanner.