The techniques of this disclosure generally relate to a modular assembly including first and second stent-grafts. The first stent-graft includes a body portion having a first diameter and a waist portion having a second diameter less than the first diameter. The waist portion is at a distal end of the first stent-graft. The second stent-graft includes a captured proximal portion configured to be located within the first stent-graft. The captured proximal portion includes a seated portion configured to be located proximal to the waist portion. The seated portion has a third diameter greater than the second diameter to form a mechanical interlock between the first stent-graft and the second stent-graft.

An implantable heart valve configured for implantation within an existing prosthetic heart valve includes a frame including struts defining a lattice region and a plurality of arches, and a central lumen extending therebetween, a plurality of protrusions extending radially outward from the plurality of struts, and a valve coupled to the frame and positioned within the central lumen.

A support system for an intraocular lens (IOL) comprising a primary intraocular ring (PIR) mountable to an eye and a secondary device (SD), the SD in communication with the PIR and movable relative to the PIR. The movement can be one or more of rotation, forward-backward movement, decentralization, tilt and angulation. The IOL can be controllably and non-invasively moved relative to the PIR, with the movement being one or more of rotation, forward-backward movement, decentralization, tilt and angulation.

A system for treating a body lumen including a first stent configured to be positioned in a body lumen and a second stent configured to be positioned in the lumen of the first stent prior to removing the first stent from the body lumen. The first stent includes a liner disposed radially inward of the tubular scaffold of the first stent to permit tissue ingrowth within a tissue ingrowth region defined between the liner and the tubular scaffold. The retrieval stent is configured to be expanded within the previously implanted first stent to cause tissue to recede from the tissue ingrowth region to facilitate removal of the first stent from the body lumen.

A prosthetic mitral valve includes an anchor assembly, a strut frame, and a plurality of replacement leaflets secured to the annular strut frame. The anchor assembly includes a ventricular anchor, an atrial anchor, and a central portion therebetween. The ventricular anchor and the atrial anchor are configured to flare radially outwards relative to the central portion. The annular strut frame is disposed radially within the anchor assembly and is attached to the anchor assembly. The central portion is configured to align with a native valve orifice and the ventricular anchor and the atrial anchor are configured to compress native cardiac tissue therebetween.

The techniques of this disclosure generally relate to a modular assembly including first and second stent-grafts. The first stent-graft includes a body portion having a first diameter and a waist portion having a second diameter less than the first diameter. The waist portion is at a distal end of the first stent-graft. The second stent-graft includes a captured proximal portion configured to be located within the first stent-graft. The captured proximal portion includes a seated portion configured to be located proximal to the waist portion. The seated portion has a third diameter greater than the second diameter to form a mechanical interlock between the first stent-graft and the second stent-graft.

A multi-part intraocular lens (IOL) with an interchangeable optic seated on a base and secured by a locking mechanism. The optic comprises an anterior surface with a diameter greater than a diameter of a ring of the base. The posterior side of the optic has a posterior surface, a transition region for contact with the base, and sidewalls and tabs radially outward of the transition region. The sidewalls and tabs overlap at least a portion of the ring to reduce or even prevent decentration and tilt of the optic. Each tab has a lateral extension for coupling to the base.

In one embodiment, an implantable prosthetic valve can comprise an annular frame comprising an inflow end and an outflow end and being radially collapsible and expandable between a radially collapsed configuration and a radially expanded configuration, and a leaflet structure positioned within the frame and secured thereto. The prosthetic valve can further comprise an outer skirt positioned around an outer surface of the frame, the outer skirt comprising pericardial tissue having a fibrous parietal layer defining a first surface of the outer skirt and a serous parietal layer defining a second surface of the outer skirt, the pericardial tissue having been fixed by cross-linking.

A prosthetic spacer assembly includes a spacer body, a first anchor, and a second anchor. The first anchor and the second anchor are each connected to the spacer body. The first anchor is configured to capture a first native valve leaflet between the first anchor and the spacer body. The second anchor is configured to capture a second native valve leaflet between the second anchor and the spacer body.

A prosthetic heart valve includes a collapsible and expandable stent having a proximal end, a distal end, an annulus section adjacent the proximal end and an aortic section adjacent the distal end, the stent including a plurality of struts. A cuff may be coupled to the stent so that a flat, bottom edge of the cuff lies adjacent the proximal end of the stent. A pattern of stitches may be circumferentially disposed around the flat bottom edge of the cuff, the pattern of stitches alternating between stitches sewn to the cuff only and stitches sewn to both the cuff and the stent.