Tissue anchors, kits that include a tissue anchor, and methods of anchoring tissue to a bone are described. An example embodiment of a tissue anchor includes a screw and a stem releasably attached to the screw. The screw defines a first opening, a second opening, and a lumen that extends from the first opening to the second opening. A portion of the stem is sized and configured to be received within the lumen defined by the screw.

Disclosed herein are implantable dual-valve devices having first and second valve structures, a connector coupled to the structures, and first and second sealing members coupled on each side of the device, along with related methods of deploying such devices.

A transdermal intraosseous device for coupling a bone stump to an external prosthetic device includes a bone fixator, an external connector and a plurality of modular interface components. The bone fixator includes a proximal portion configured for anchoring into the bone stump of the patient and a distal portion including a base collar configured for subcutaneous implantation. The external connector has a distal portion for coupling to the external prosthetic device and a proximal portion for coupling to the distal portion of the bone fixator. Each interface component can be removably coupled to the base collar and has different size and shape to provide a surgeon-selected transition between the prosthetic device and the patient's skin.

A compressible and expandable stent assembly for implantation in a body lumen such as a mitral valve, the stent assembly including at least one stent barrel that is shaped and sized so that it allows for normal operation of adjacent heart structures. One or more stent barrels can be included in the stent assembly, where one or more of the stent barrels can include a cylinder with a tapered edge.

A knee spacer device configured to be implanted temporarily at the joint area between the tibia and femur of a patient to replace an infected joint prosthesis and to maintain the size or spaces of the patient's joint area before implanting a new prosthesis includes a tibial unit and a femoral unit.

A compressible and expandable stent assembly for implantation in a body lumen such as a mitral valve, the stent assembly including at least one stent barrel that is shaped and sized so that it allows for normal operation of adjacent heart structures. One or more stent barrels can be included in the stent assembly, where one or more of the stent barrels can include a cylinder with tapered edge.

The present invention relates to an intraluminal vessel prosthesis system for implantation in the region of the aortic arch of a patient, comprising a hollow cylindrical main vessel prosthesis, wherein the hollow cylindrical main vessel prosthesis is configured and dimensioned for implantation in the region of the artic arch and the descending aorta (Aorta descendens) of the patient and wherein the main vessel prosthesis, at least over part of the length L2 of the anchoring vessel prosthesis, and wherein the diameter D2 of the anchoring vessel prosthesis is at least 45% smaller than the diameter D1 of the main vessel prosthesis and wherein the length L2 of the anchoring vessel prosthesis is shorter than the length L2 of the main vessel prosthesis.

Methods for the rapid retraction of trans-catheter heart valve delivery systems are provided. A rapid retraction trans-catheter heart valve delivery system comprises a catheter based delivery system. The delivery system has internal mechanisms that allow for the controlled deployment of a heart valve prosthesis, as well as mechanisms that allow for quickly closing the catheter once the heart valve prosthesis has been implanted. This rapid retraction ability allows for reduced procedural durations and thus reduced risk to the patient.

A method of using a self-adjusting stent assembly includes estimating body lumen diameter(s) associated with a portion of a body lumen in which a stent assembly will be placed; determining, based on the estimated diameter(s), target expanded stent diameter(s) of the stent assembly which is to be placed in the portion of the body lumen; selecting the stent assembly for stenting the portion of the body lumen, wherein the stent assembly is configured to: expand from an initial to expanded diameters within a range of expanded diameters; wherein the range of expanded diameters is from about 9 mm to about 5.5 mm; and wherein the target expanded stent diameter(s) is/are within the range of expanded diameters; and apply a chronic radial force to a wall that forms the portion of the lumen, wherein the radial force is less than about 0.33 N/mm; and implanting the stent assembly in the portion of the body lumen.

A method of implanting a prosthetic heart valve includes determining from a set of expandable prosthetic heart valves a first prosthetic heart valve. The first prosthetic heart valve has a first nominal diameter less than a native annulus diameter. The method further includes determining a first suggested expanded diameter for the first prosthetic heart valve based on the native annulus diameter, wherein the first suggested expanded diameter is greater than the first nominal diameter, and determining a pressure gradient across the first prosthetic heart valve at the first suggested expanded diameter based at least in part on pressure values from hemodynamic data of the first prosthetic heart valve. The method further includes selecting the prosthetic heart valve from the set of expandable prosthetic heart valves with the suggested expanded diameter resulting in the lowest pressure gradient for implantation from the set of prosthetic heart valves.