Described are embodiments of a multilaminate or multiple layer implantable surgical graft with an illustrative graft comprising a remodelable collagenous sheet material, the graft including one or more interweaving members to stitch together the graft to help prevent the layers from delaminating or separating during handling and the initial stages of remodeling. The interweaving members may comprise lines of suture, thread, individual stitches, strips of material, etc. that are woven through the layers of biomaterial in a desired pattern. In one embodiment, the interweaving members comprise a pharmacologically active substance, such as a drug, growth factors, etc. to elicit a desired biological response in the host tissue. In another embodiment, the graft further comprises a reinforcing material, such as a synthetic mesh, within the layers of remodelable biomaterial and stitched together by one or more interweaving members.

A structure includes a plurality of elongated members flexibly coupled together. The flexible coupling between the elongated members allows the structure to transition between a first and second outer shape. Each of the elongated members has embedded ferromagnetic particles aligned to cause the respective elongated member to move in a predetermined deflection relative to each other in response to an applied magnetic field. The predetermined deflections cause the elongated members to collectively move the structure between the first and second outer shapes. An enclosure is coupled to the structure. The movement of the structure between the first and second shapes performs at least one of compressing and expanding a volume of the enclosure

Disclosed herein are methods, devices and compositions for degradable medical devices and/or compositions that provide local and/or systemic delivery of at least one active agent.

An implant that has a central body or core that functions as a spine, with extending articulating segments that extend from the spine. The articulating segments define a space between each section to allow the implant to be compressed and bent, such that the space between each section can be compressed or expanded. A specific use for the implant is as a sinus implant. Specific embodiments of the implant are useful in correcting missing tissue in the inferior turbinate. Specific embodiments are sized and shaped to treat empty nose syndrome (ENS). Embodiments also relate to an implant that has a port for allowing various fluids or solutions to be flushed into the implant and released through the implant surface.

The disclosure describes new devices and methods for vascularizing devices and methods for implanted diagnostics and therapeutics. The present disclosure provides, in certain embodiments, a device containing a degradable shell and a non-degradable core. In certain embodiments, the non-degradable core can include encapsulated therapeutic cells and/or biosensors, wherein the degradable shell serves as a scaffold for blood vessel growth, resulting in enhanced blood flow to the cells and/or biosensors.

Compositions and methods are provided for the generation or treatment of chronic tympanic membrane perforation by modulation of HB-EGF activity.

Described are implantable devices having expandable reservoirs for the sustained release of therapeutic agents. The device is configured to be at least partially implanted in an eye and includes a retention structure and a penetrable element coupled to and extending within at least a portion of the retention structure. A porous drug release mechanism is positioned in fluid communication with an outlet of the device; and a reservoir having a volume configured to contain one or more therapeutic agents is in fluid communication with the outlet through the porous drug release mechanism. The device is at least partially inserted along an axis of insertion. The reservoir enlarges from an insertion configuration having a first three-dimensional shape to an expanded configuration having a second three-dimensional shape, the second three-dimensional shape being eccentrically positioned relative to the axis of insertion.

An implantable device for delivering a therapeutic agent to treat an ear of a patient includes a body having a distal end region and a proximal end region. The body defines, at least in part, a reservoir configured to contain the therapeutic agent. The device includes a shaft attached to the distal end region of the body and a lumen extending through the shaft having at least one inlet at a proximal end region in fluid communication with the reservoir and at least one outlet at a distal end region. Upon implantation of the body in a region of the ear, a length of the shaft is sufficient to extend from the body to at least the round window membrane of the ear. The device is configured to deliver the therapeutic agent to the ear from the reservoir via passive diffusion. Related devices and methods are described.

A degradable drug-loaded stent and a manufacturing method therefor. The degradable drug-loaded stent comprises a stent body, an outer surface of the stent body being provided with a drug-loaded groove, the stent body having a contracted state and an expanded state, the stent body being capable of switching from the contracted state to the expanded state via radial expansion, the stent body being a mesh columnar structure when in the expanded state, the depth of the drug-loaded groove being 10%-60% of the wall thickness of the mesh columnar structure.

The present invention provides a method for stabilizing a fractured bone. The method includes positioning an elongate rod in the medullary canal of the fractured bone and forming a passageway through the cortex of the bone. The passageway extends from the exterior surface of the bone to the medullary canal of the bone. The method also includes creating a bonding region on the elongate rod. The bonding region generally aligned with the passageway of the cortex. Furthermore, the method includes positioning a fastener in the passageway of the cortex and on the bonding region of the elongate rod and thermally bonding the fastener to the bonding region of the elongate rod while the fastener is positioned in the passageway of the cortex.