Techniques and systems for distracting a spinal disc space and supporting adjacent vertebrae are provided. Trial instruments are insertable into the disc space to determine a desired disc space height and to select a corresponding implant. Implants can be also be self-distracting and the implant providing the desired disc space height can be implanted in the spinal disc space.

Nasal implant obtained by additive manufacturing, comprising a main portion and a return portion connected by an intermediate portion, the main and return portions forming an angle of between 25° and 90°, said implant is made from a biocompatible ceramic of synthetic origin; said implant has an average macroporosity characterized by: a density of material of between 20% and 95% by volume, said density of material being higher in said intermediate portion than in said main portion; cavities defining sections of cavities, said sections of cavities each having a diameter of between 0.3 mm and 1 mm; said sections of cavities each having an area and a form substantially equal over the entire implant.

The present disclosure relates to a foraminifera-derived bone graft material. A foraminifera-derived bone graft material according to an aspect of the present disclosure has remarkable abilities in terms of cell proliferation, cell adhesion, and osteoblast differentiation, and includes a structure that can support newly formed bones. Accordingly, the foraminifera-derived bone graft material may be effectively utilized as a bone graft material.

An extended release immunomodulatory implant operatively arranged to facilitate bone morphogenesis, including an inner portion including one or more interleukins, and an outer portion including an immunomodulatory stimulant such as an antigen.

A lumbar and/or cervical disc prosthetic formed with three primary layers, including a superior (upper) plate, inferior (lower) plate, and intermediate core, in a sandwiched configuration. The superior plate member is adapted to be secured on one side to an upper vertebra in a spinal column, the inferior lower plate member is adapted to be secured on one side to a lower vertebra in the spinal column, and the core permits a limited degree of articulation of the superior plate relative to the inferior plate. Both the superior plate member and inferior plate member are constructed of two different materials, metal and plastic, such that the outward surfaces expose islands of metal surrounded by plastic to deter bone ongrowth to the plastic while promoting bone ongrowth to the metal islands. The prosthetic disc preserves spinal articulation years after the procedure.

A tissue fixation system is provided for dynamic and rigid fixation of tissue. A fastener connected with an elongate fastening member, such as a cable, wire, suture, rod, or tube, is moved through a passage between opposite sides of tissue. The fastener is provided with a groove that accommodates at least a portion of the fastening member to reduce the profile during the movement through the passage. The fastener is then pivoted to change its orientation. A second fastener can then be connected with the fastening member. While tension is maintained in the fastening member, the fasteners are secured against relative movement. This may be done by deforming the fastening member, either the first or second fasteners, or a bushing placed against the second fastener.

An extended release immunomodulatory implant operatively arranged to facilitate bone morphogenesis, including an inner portion including one or more interleukins, and an outer portion surrounding the inner portion, the outer portion including an antigen operatively arranged to activate an innate immune system.

Embodiments disclosed herein relate scaffolds containing fluoridated apatites sintered at a temperature of at least 950° C. to increase integration of the scaffold in a patient, as well as methods of making and using the same.

The present patent application is directed to compositions and shaped structures implantable into mammalian bodies, the compositions and shaped structures having localized bioactive surfaces.

The present invention relates to a bone regeneration material comprising: a solid first phase of hydroxyapatite of natural origin which is macroporous, having pores of diameters greater than or equal to 50 μm, this phase of hydroxyapatite is a crystalline solid phase of hydroxyapatite, whose crystals have a size comprised between 20 and 120 nm, and this solid phase of hydroxyapatite has a specific surface area comprised between 8 and 20 m.sup.2/g, the method of production and a method of bone repair based on this bone regeneration material.