Hard-tissue implants are provided that include a bulk implant, a face, pillars, slots, and at least one support member. The pillars are for contacting a hard tissue. The slots are to be occupied by the hard tissue. The at least one support member is for contacting the hard tissue. The hard-tissue implant has a Young's modulus of elasticity of at least 3 GPa, and has a ratio of the sum of (i) the volumes of the slots to (ii) the sum of the volumes of the pillars and the volumes of the slots of 0.40:1 to 0.90:1. Methods of making and using hard-tissue implants are also provided.

A bone implant for enclosing bone material is provided. The bone implant comprises a mesh having an inner surface and an outer surface opposing the inner surface. The inner surface is configured to receive a bone material when the inner surface of the mesh is in an open configuration. A plurality of projections are disposed on or in at least a portion of the inner surface of the mesh. The plurality of projections extend from at least the portion of the inner surface of the mesh and are configured to engage a section of the inner surface of the mesh or a section of the outer surface of the mesh or both sections of the inner and outer surfaces of the mesh in a closed configuration so as to enclose the bone material. A tray, a kit and a method of making the bone implant are also provided.

An expandable spinal implant includes a distal projection extending from only one side of the implant, ending in an anterior tip, the anterior portion and anterior tip defining an elongated distal end hook, which is wider than the proximal end. The distal end hook rotates around the spinal cord, aligning the implant with a desired pathway, then inserts into place in the disc space between the vertebrae. The elongated widened distal end hook provides a TLIF approach, distributes loads, provides anterior rim engagement, and creates lordosis.

The invention relates generally to generation of biomimetic scaffolds for bone tissue engineering and, more particularly, to multi-level lamellar structures having rotated or alternated plywood designs to mimic natural bone tissue. The invention also includes methods of preparing and applying the scaffolds to treat bone tissue defects. The biomimetic scaffold includes a lamellar structure having multiple lamellae and each lamella has a plurality of layers stacked parallel to one another. The lamellae and/or the plurality of layers is rotated at varying angles based on the design parameters from specific tissue structural imaging data of natural bone tissue, to achieve an overall trend in orientation to mimic the rotated lamellar plywood structure of the naturally occurring bone tissue.

A bone implant includes a main body in the form of a hollow body open on both sides in the axial direction. The main body includes a load-bearing material. An encasing body at least partially encases the main body on the outside and includes an in vivo degradable/in vivo resorbable material. Alternatively, the encasing body includes a multiplicity of shaped bodies protruding from the main body in the radial direction that include an in vivo degradable/in vivo resorbable material. A method for producing the bone implant includes an additive manufacturing process. The main body can be at least partially encased by the encasing body in the additive manufacturing process.

A three-dimensional shaped object can achieve both of a property in the case of a high dense degree and a property in the case of a low dense degree, and have a high strength. The three-dimensional shaped object includes a dense portion formed on one side so as to be dense, and a porous portion formed on an opposite side so as to be porous. The dense portion and the porous portion are formed by a reaction product of a ceramic material with a chelating agent.

Provided are a bone graft composition and a preparation method thereof, and more particularly, a bone graft composition provided in the form of a putty formulation by mixing calcium phosphate compound particles with hydrogel, having excellent physical properties, which is easy to inject, and which maintains its structure even in an in vivo environment after implantation, thereby enabling sustained release of a drug loaded therein.

Provided herein are biomimetic osteochondral implants that are generally useful for the at least partial resurfacing of damaged cartilage within a joint. The implants are constructed to have a modular, layered structure in which the physical properties (e.g., stiffness and lubricity) or dimensions of each layer can be adjusted (e.g., by using the appropriate material and controlling the thickness thereof) based on the anatomy to be replaced. For example, the material and or thicknesses of the layers can be selected to approximate the physical properties and/or dimensions of cartilage (and, optionally, chondral and subchondral bone). Also provided herein are methods of treatment involving the use of said biomimetic osteochondral implants to repair an osteochondral defect in a joint.

An implantable medical device, such as an intervertebral spacer, may comprise a polymeric component and a metallic component. The metallic component can contain both porous metal and substantially-solid metal. The polymeric material can contain particles of an osseointegrative material. The metallic component can be more protruding toward bone than the polymeric component while having a smaller dimension of roughness than the polymeric component. In embodiments, the pin may press-fit against substantially solid metal. The porous metal may surround solid metal which in turn may surround the pin. The pin may have a press-fit with metal and a looser fit with polymeric component, if the metal components and polymeric components are trapped. A pin may connect superior and inferior metal components by a press-fit. The central opening may be exposed to porous metal and also to substantially-solid metal and to polymer. Specific geometries of implants are disclosed.

Disclosed is an artificial bone structure for replacement of natural bone and comprising a solid cylindrical portion having an elongate shape. The solid cylindrical portion comprises an auxetic structure of a plurality of artificial osteons and each artificial osteon comprises a first hexagonal unit and a second hexagonal unit having corresponding edges. Furthermore, a first artificial osteon and a second artificial osteon of the plurality of artificial osteons are connected to each other using an edge of a third artificial osteon and about a central axis of each of the first artificial osteon and the second artificial osteon. Moreover, the artificial bone structure comprises a hollow cylindrical portion having an elongate shape, disposed inside of and concentrically with the solid cylindrical portion. The hollow cylindrical portion is configured to comprise an artificial bone marrow therein.