Humeral prosthetic implants, systems, kits and methods of forming and using the humeral prosthetic implants, systems and kits are disclosed. The humeral prosthetic implants include proximal cup portions and distal stem portions, wherein the proximal cup portion is joined to the distal stem portion at a desired offset and/or angle configured based on an analysis of the humeral diaphysis and/or metaphysis offset in a patient. The humeral prosthetic implants may also include an adapter configured to join the proximal cup component with the stem component, wherein the adapter is configured to join the stem component to the stemless cup at a desired offset and/or angle.

A process for producing an antibacterial coating composition for implants. The process includes the steps i) reaction of a monomer A which is based on (meth)acrylic acid and contains at least one epoxide with a polyguanidine by reaction of an amino group of the polyguanidine with the epoxide to give a (meth)acrylic acid-polyguanidine macromolecule and ii) polymerization of the (meth)acrylic acid-polyguanidine macromolecule with a monomer B which contains at least one polymerizable double bond and at least one phosphonate group by free-radical polymerization of the (meth)acrylic acid unit and the double bond.

A process for producing an antibacterial coating composition for implants. The process includes the steps i) reaction of a monomer A which is based on (meth)acrylic acid and contains at least one epoxide with a polyguanidine by reaction of an amino group of the polyguanidine with the epoxide to give a (meth)acrylic acid-polyguanidine macromolecule and ii) polymerization of the (meth)acrylic acid-polyguanidine macromolecule with a monomer B which contains at least one polymerizable double bond and at least one phosphonate group by free-radical polymerization of the (meth)acrylic acid unit and the double bond.

The present invention disclosed a method of producing a three-dimensional porous tissue in-growth structure. The method includes the steps of depositing a first layer of metal powder and scanning the first layer of metal powder with a laser beam to form a portion of a plurality of predetermined unit cells. Depositing at least one additional layer of metal powder onto a previous layer and repeating the step of scanning a laser beam for at least one of the additional layers in order to continuing forming the predetermined unit cells. The method further includes continuing the depositing and scanning steps to form a medical implant.

A surface coating for a medical instrument includes an interference filter having at least one dielectric layer and at least one metallic layer arranged one above another. At least one of the at least one metallic layer and the at least one dielectric layer is adapted to be structurally altered by action of a corrosive environment on the surface coating such that the surface coating is convertible from a first state to a second state. In the first state, the surface coating has a first spectral reflectivity. In the second state, the surface coating has a second spectral reflectivity that is different from the first spectral reflectivity.

The invention is generally related to an intervertebral implant for replacing an intervertebral disc of the human spine. The intervertebral implant includes a first conformable endplate, the first conformable endplate being conformable to a boney vertebral endplate under an anatomical load, a second endplate and a core between the endplates, wherein the first conformable endplate partitions the core from the boney vertebral endplate, whereby the core does not contact the boney vertebral endplate. The invention is also directed to a method of replacing an intervertebral disc. The method includes removing at least a portion of an intervertebral disc to form an intervertebral disc space, implanting a first conformable endplate, into the intervertebral disc space and in contact with a first honey vertebral endplate, the first conformable endplate being conformable to the first boney vertebral endplate under an anatomical load; implanting a second endplate into the intervertebral disc space and in contact with a second boney vertebral endplate; and implanting a core between the first conformable endplate and the second endplate, wherein the first conformable endplate partitions the core from the first boney vertebral endplate, whereby the core does not contact the first boney vertebral endplate.

The present invention disclosed a method of producing a three-dimensional porous tissue in-growth structure. The method includes the steps of depositing a first layer of metal powder and scanning the first layer of metal powder with a laser beam to form a portion of a plurality of predetermined unit cells. Depositing at least one additional layer of metal powder onto a previous layer and repeating the step of scanning a laser beam for at least one of the additional layers in order to continuing forming the predetermined unit cells. The method further includes continuing the depositing and scanning steps to form a medical implant.

The invention is generally related to an intervertebral implant for replacing an intervertebral disc of the human spine. The intervertebral implant includes a first conformable endplate, the first conformable endplate being conformable to a boney vertebral endplate under an anatomical load, a second endplate and a core between the endplates, wherein the first conformable endplate partitions the core from the boney vertebral endplate, whereby the core does not contact the boney vertebral endplate. The invention is also directed to a method of replacing an intervertebral disc. The method includes removing at least a portion of an intervertebral disc to form an intervertebral disc space, implanting a first conformable endplate, into the intervertebral disc space and in contact with a first honey vertebral endplate, the first conformable endplate being conformable to the first boney vertebral endplate under an anatomical load; implanting a second endplate into the intervertebral disc space and in contact with a second boney vertebral endplate; and implanting a core between the first conformable endplate and the second endplate, wherein the first conformable endplate partitions the core from the first boney vertebral endplate, whereby the core does not contact the first boney vertebral endplate.

Compositions including a surface or film comprising nanofibers, nanotubes or microwells comprising a bioactive agent for elution to the surrounding tissue upon placement of the composition in a subject are disclosed. The compositions are useful in medical implants and methods of treating a patient in need of an implant, including orthopedic implants, dental implants, cardiovascular implants, neurological implants, neurovascular implants, gastrointestinal implants, muscular implants, and ocular implants.

Humeral prosthetic implants, systems, kits and methods of forming and using the humeral prosthetic implants, systems and kits are disclosed. The humeral prosthetic implants include proximal cup portions and distal stem portions, wherein the proximal cup portion is joined to the distal stem portion at a desired offset and/or angle configured based on an analysis of the humeral diaphysis and/or metaphysis offset in a patient. The humeral prosthetic implants may also include an adapter configured to join the proximal cup component with the stem component, wherein the adapter is configured to join the stem component to the stemless cup at a desired offset and/or angle.