A comparator may automatically detect and quantify subtle and/or microscopic variance to a feature of a three-dimensional (“3D”) object in a reproducible manner based on point cloud imaging of that 3D object. The comparator may isolate a first set of data points, that represent the object feature at a first time, in a reference point cloud, and may isolate a second set of data points, that represent the same but altered object feature at a different second time, in a non-reference point cloud. The comparator may detect variance between positional values and visual characteristic values of the second set of data points and the corresponding positional values and visual characteristic values of the first set of data points, and may quantify a change occurring to the object feature between the first time and the second time based on a mapping of the variance to a particular unit of measure.

In one aspect, a method to detect white blood cells and/or white blood cell subtypes from non-invasive capillary videos is featured. The method includes acquiring a first plurality of images of a region of interest including one or more capillaries of a predetermined area of a human subject from non-invasive capillary videos captured with an optical device, processing the first plurality of images to determine one or more optical absorption gaps located in said capillary, and annotating the first plurality of images with an indication of any optical absorption gap detected in the first plurality of images. The method also includes acquiring a second plurality of images of the same region of interest of the same capillary with an advanced optical device capable of resolving cellular structure of white blood cells and white blood cell subtypes and spatiotemporally annotating the second plurality of images with an indication of any white blood cell detected and/or a subtype of any white blood cell detected in the second plurality of images. The method also includes inputting the first plurality of images and annotated information from the first plurality of images and annotated information from the spatiotemporally annotated second plurality of images into a machine learning subsystem configured to determine a presence of white blood cells and/or the subtype of any white blood cells present in the one or more optical absorption gaps in the first plurality of images.

A method for characterizing contractions in cell cultures of contractile cells, the method comprising: acquiring a series of images of the contractile cells; for each image in the series of images, computing a movement index characterizing the rate of change in mean absolute pixel intensity variations across the whole image; and using the movement index to assess the contractions of the contractile cells. Also, applications of the method to the study of cardiac tissue analogs and other cell cultures, and a culture system used to implement the method.

A method for studying the behavior of an animal in an experimental area including stimulating the animal using a stimulus device; collecting data from the animal using a data collection device; analyzing the collected data; and developing a quantitative behavioral primitive from the analyzed data. A system for studying the behavior of an animal in an experimental area including a stimulus device for stimulating the animal; a data collection device for collecting data from the animal; a device for analyzing the collected data; and a device for developing a quantitative behavioral primitive from the analyzed data. A computer implemented method, a computer system and a nontransitory computer readable storage medium related to the same. Also, a method and apparatus for automatically discovering, characterizing and classifying the behavior of an animal in an experimental area. Further, use of a depth camera and/or a touch sensitive device related to the same.

Disclosed is a computer-implemented method of determining a correspondence between a region of interest as it appears in a first digital medical patient image and as it appears in a second digital medical image. The correspondence is determined by calculating the ratio of overlap of the region of interest with a data object defining an anatomical body part in the first image and the second image and determining whether the larger of the two ratios exceeds a threshold. If the threshold is exceeded, the method assumes that the appearances in the two images describe the same region of interest.

Determining a composite score includes deriving, based on an image set that includes at least one three-dimensional image of the synovial joint, first and second information. The first information indicates cumulative damage to the synovial joint. The second information indicates either one or both joint pain and loss of function of the synovial joint. The resulting composite score provides an objective measure of joint damage or an extent of joint disease.

Presented is a wireless portable ultrasound acquisition system for dental imaging, having an ultrasound probe with a control switch connected through a cable to a portable ultrasound acquisition system that communicates wirelessly with a smart tablet or a phone display to display the ultrasound images. The system uses ultrasound signals to create images of alveolar bone structure and boundaries of enamel, dentin and gingiva of a patient.

System and method for diagnosing a disease using image classification is provided. The method includes receiving diagnostic images associated with a subject. The diagnostic images comprise a first image and a second image captured at a first instance of time and at a second instance of time, respectively. The method further includes extracting feature maps from the first image and the second image, using a first pipeline and a second pipeline of stacked convolutional layers of a temporal convolutional neural network (CNN) model respectively. The method further includes identifying relevant feature maps from the feature maps using temporal CNN layer of the temporal CNN model, generating a concatenated feature map based on the relevant feature maps, determining an image class corresponding to the second image using fully connected layers of the temporal CNN model, and diagnosing the disease associated with the subject based on the image class.

Described herein is medical imaging technology for concurrent and simultaneous synthesis of a medical CA-free-AI-enhanced image and medical diagnostic image analysis comprising: receiving a medical image acquired by a medical scanner in absence of contrast agent enhancement; providing the medical image to a computer-implemented machine learning model; concurrently performing a medical CA-free-AI-enhanced image synthesis task and a medical diagnostic image analysis task with the machine learning model; reciprocally communicating between the image synthesis task and the image analysis task for mutually dependent training of both tasks. Methods and systems and non-transitory computer readable media are described for execution of concurrent and simultaneous synthesis of a medical CA-free-AI-enhanced image and medical diagnostic image analysis.

System and methods for identifying a brain condition of a patient subject to a plurality of disease states are provided, in some aspects, the method includes receiving imaging data associated with a patient's brain acquired using an imaging system, and constructing a classifier having signatures corresponding to a plurality of disease states. The method also includes applying the classifier to the imaging data to determine a degree to which the patient expresses at least one of the plurality of disease states, and determining a brain condition of the patient using the determined degree. The method further includes generating a report indicative of the brain condition of the patient.