Disclosed is a medical image data processing method for determining a clinical target volume for a medical treatment, wherein the method comprises executing, on at least one processor (3) of at least one computer (2), steps of: a) acquiring (S1) first image data describing at least one image of an anatomical structure of a patient; b) acquiring (S2) second image data describing an indicator for a preferred spreading direction or probability distribution of at least one target cell; c) determining (S3) registration data describing a registration of the first image data to the second image data by performing a co-registration between the first image data and the second image data using a registration algorithm; d) determining (S4) gross target region data describing a target region in the at least one image of the anatomical structure based on the first image data; e) determining (S5) margin region data describing a margin around the target region based on the gross target region data; f) determining (S6) clinical target volume data describing a volume in the anatomical structure for the medical treatment based on the registration data, the gross target region data and the margin region data.

The application provides a method, apparatus and computer program product for denoising a magnetic resonance diffusion tensor, wherein the method comprises: collecting data of K space; calculating a maximum likelihood estimator of a diffusion tensor according to the collected data of K space; calculating a maximum posterior probability estimator of the diffusion tensor by using sparsity of the diffusion tensor and sparsity of a diffusion parameter and taking the calculating maximum likelihood estimator as an initial value; and calculating the diffusion parameter according to the calculated maximum posterior probability estimator. The application solves the technical problem in the prior art of how to realize high precision denoising of diffusion tensor while not increasing scanning time and affecting spatial resolution, achieves the technical effects of effectively suppressing noises in the diffusion tensor and improving the estimation accuracy of the diffusion tensor.

A data processing method for determining a path of a neural fibre in a patient, comprising the steps of: a) acquiring an atlas dataset representing an atlas of a fibrous structure comprising the neural fibre b) acquiring a nerve indicating dataset comprising information suitable for identifying the neural fibre in the patient c) calculating a matched atlas dataset by registering the atlas dataset with the nerve indicating dataset d) obtaining a generic path of the neural fibre from the matched atlas dataset e) defining a constraining volume in the patient around the generic path, the constraining volume having at least two end surfaces on which the generic path ends and f) determining the path of the neural fibre between end surfaces using a probabilistic approach, wherein the determined path lies completely within the constraining volume.

A magnetic resonance diffusion tensor imaging method and corresponding device. The method includes acquiring omnidirectionally sampled diffusion weighted images of a plurality of training samples; performing diffusion tensor model fitting and undersampling for the omnidirectionally sampled diffusion weighted images of each training sample to obtain an omnidirectionally sampled diffusion tensor image and an undersampled diffusion weighted image; training a deep learning network, with the omnidirectionally sampled diffusion tensor images of the plurality of training samples as training targets and the undersampled diffusion weighted images as training data; acquiring undersampled diffusion weighted images of a target object; and inputting the undersampled diffusion weighted images of target objects into the trained deep learning network to obtain the predicted omnidirectionally sampled diffusion tensor images of the target objects. Also, a fiber tracking method and corresponding device.

A method of predicting therapeutic effects of a treatment for cognitive impairment for an individual using the individual's predicted age difference (PAD), the method comprising scanning the individual's brain with a scanning device so as to acquire at least one medical brain image at the beginning of the treatment; processing the medical brain image to obtain at least one feature of the image; generating a PAD value of the individual based on the at least one feature of the image; comparing the PAD value with a reference value; and predicting the therapeutic effects of the treatment for cognitive impairment using the comparison result of the PAD value and the reference value.

A method for registering multiple data types of diverse modalities for a target volume includes acquiring at least at least two datasets associated with the target volume where the at least two datasets having different modalities. Using information field theory and entropy spectrum pathways theory, a local connectivity matrix is constructed for one or both of spatial connectivity and temporal connectivity for each of the datasets. The local connectivity matrices for the datasets are fused into a common coupling matrix and the datasets are merged to generate a registered image displaying the spatial and temporal features within the target volume.

A method of predicting therapeutic effects of a treatment for cognitive impairment for an individual using the individual's predicted age difference (PAD), the method comprising scanning the individual's brain with a scanning device so as to acquire at least one medical brain image at the beginning of the treatment; processing the medical brain image to obtain at least one feature of the image; generating a PAD value of the individual based on the at least one feature of the image; comparing the PAD value with a reference value; and predicting the therapeutic effects of the treatment for cognitive impairment using the comparison result of the PAD value and the reference value.

A method for predicting clinical severity of a neurological disorder includes steps of: a) identifying, according to a magnetic resonance imaging (MRI) image of a brain, brain image regions each of which contains a respective portion of diffusion index values of a diffusion index, which results from image processing performed on the MRI image; b) for one of the brain image regions, calculating a characteristic parameter based on the respective portion of the diffusion index values; and c) calculating a severity score that represents the clinical severity of the neurological disorder of the brain based on the characteristic parameter of the one of the brain image regions via a prediction model associated with the neurological disorder.

Systems and methods for mapping brain perivascular spaces. A system may include a memory to store one or more images of a brain of a patient. The system may further include a processor coupled to the memory. The processor may be configured to obtain a first and a second image of the brain. The processor may be further configured to combine the first image and the second image to preserve and magnify structures including the brain perivascular spaces within the image of the brain. The processor may be further configured to determine the brain perivascular spaces within the combined image of the brain of the patient. The processor may be further configured to generate a three-dimensional (3-D) map of the perivascular spaces. The system may further include a display configured to display the perivascular spaces to an operator.

A method and system for image segmentation systems and related methods of automatically segmenting cardiac MRI images using deep learning methods. One example method includes inputting MRI volume data from a MRI scanner, segmenting the MRI volume data with a whole volume segmentation analysis module, assembling the segmented MRI volume data into a 3D volume assembly with a 3D volume assembly module, determining the 3D volume assembly for anatomic plausibility with an anatomic plausibility analysis module, and outputting a final segmented 3D volume assembly.