This disclosure relates to equipment utilized to manufacture chemical agents, particularly biopharmaceuticals, using Disposable Containers (DCs).

A biocontainer film enhanced with an abrasion resistant or “cut-proof” substrate. Such substrates can be combined with current biocontainer materials, via various techniques of embedding, coextrusion or laminating, to maintain the cleanliness and low extractables already validated for biotech manufacturing. The substrate of choice may be constructed from materials known to be more resistant to abrasion and sharp razor type cuts or from materials oriented in such a way to prevent puncture to occur. The new substrate must also be flexible to allow for typical folding as demonstrated by current packaging practices. The new substrate may be constructed from materials other than polymers such as metal, glass or carbon or in combination with polymers. A non-constrained pressure test is also disclosed.

The present disclosure provides a method for conducting a pressure test on an apparatus. The method may include selecting a maximum test pressure for the pressure test, providing a first volume of liquid in the enclosed space and estimating a volume of gas in the enclosed space. The method may further include calculating a volume of additional liquid necessary to bring the enclosed space to the maximum test pressure, providing the volume of additional liquid in the enclosed space, and observing pressure of the enclosed space.

Setting and maintaining proper pre-charge air pressure in a diaphragm or bladder-type expansion tank of any fluid system is essential for safe and efficient operation of that system. In usual practice, pre-charge air pressure checks are done by emptying the system of fluid and connecting an analog air gauge to the air input of the expansion tank. In this invention a pressure sensor that is permanently coupled to the fluid volume of the expansion tank is used to also evaluate the pre-charge air pressure in the tank. By employing a single sensor for both fluid and pre-charge air pressure evaluation, the problem of inconsistent calibration between fluid sensing and air pre-charge measuring devices is eliminated. Using the same permanently installed sensor for every test or adjustment in a given system eliminates the problem of variations in calibration between different sensors or gauges used at different testing times.

A method is provided for detecting leaks in a disposable medical fluid cassette that includes a base and a flexible membrane attached to the base in such a way that the base and the flexible membrane cooperate to at least partially form a fluid passageway. The method includes applying a first force to the flexible membrane, measuring a first physical property of a system that includes the medical fluid cassette a medical fluid pumping machine, removing the first force from the flexible membrane, applying a second force to the flexible membrane, measuring a second physical property of the system, and determining whether the medical fluid cassette leaks based on a comparison of the first physical property and the second physical property.

The present application provides a self-diagnostic gas density relay and a use method thereof, the gas density relay includes a gas density relay body, a gas density detection sensor, at least one diagnostic sensor, and an intelligent control unit; where the diagnostic sensor is configured to acquire deformation quantities of components that generate deformations, and/or positions or displacement quantities of components that generate displacements when the pressure changes, or the temperature changes, or the gas density changes in the gas density relay body; and the intelligent control unit is respectively connected with the gas density detection sensor and the diagnostic sensor, receives data acquired by the gas density detection sensor and/or the diagnostic sensor, and diagnoses a current working state of the gas density relay body. The present application is used for monitoring a gas density of the gas-insulated or arc-extinguished electrical equipment, and at the same time, on-line self-inspection for the gas density relay is completed, so that efficiency is increased, no maintenance is realized, operation and maintenance costs are greatly reduced, and safe operation of a power grid is guaranteed.

In a method for determining a fluid density of a fluid in an encapsulated electrical device a sensor unit is used to acquire measurement data. The fluid density is derived from the measurement values. Weather data relating to weather conditions in an environment of the electrical device are collected. Via machine learning, a digital model is generated for the influence of the weather conditions on a measurement deviation of a measurement value from the true fluid density. Using the digital model, a correction value is calculated for measurement values according to the weather data and a measurement value is corrected using the correction value.

A liquid chromatography monitoring system comprises a computer or electronic controller comprising computer-readable instructions operable to: (a) draw a fluid into a syringe pump; (b) configure a valve so as to fluidically couple the pump to either a fluidic pathway through a fluidic system or to a plug that prevents fluid flow; (c) cause the syringe pump to progressively compress the fluid therein or expel the fluid to the fluidic pathway, while measuring a pressure of the fluid; (d) determine a profile of the variation of the measured pressure; (e) compare the determined profile to an expected profile that depends upon the fluid; and (f) provide a notification of a sub-optimal operating condition or malfunction if the determined profile varies from the expected profile by greater than a predetermined tolerance.

The present invention specifically relates to the pneumatic and electronic application of a pneumatic leak meter based on absolute pressure drop measurement having the peculiarity of compensating for ambient variations such as ambient temperature and temperature of the measured part, as well as mechanical deformations of the component being tested caused by the pressure being applied.

The present invention concerns a group (10) and method for measuring the pressure in closed containers (30) made from optically transparent material at least at a portion of a top space (31) thereof, and a filling and/or packaging plant (100) using the measuring group. In particular the present invention concerns a group and a method for contactlessly measuring the pressure in closed containers, able to be used directly in automatic filling and/or packaging plants operating at high speed, without the need to stop or slow down such plants or in any case to pick up the containers from the same. The measuring group for measuring the pressure in closed containers (30) made from optically transparent material at least at a portion of a top space (31) thereof, comprises at least one inspection area (20) adapted for the passage of at least one portion of a top space (31) of a closed container (30) of said closed containers; at least one laser source (11) with optical axis (A) for the emission of a laser beam at a wavelength tunable with an absorption wavelength of a gas contained in the top space (31) of the closed container (30), the at least one laser source (11) being positioned so as to direct the laser beam towards the at least one inspection area (20); at least one detector (12) positioned so as to detect at least one portion of the laser beam emitted by the laser source (11) once it has travelled through the inspection area (20) and to provide in output data representative of an absorption spectrum of said gas as a consequence of the passage of the laser beam through the inspection area (20); at least one device (14,14′) for detecting the signal acquisition time period corresponding to the passage of said at least one portion of a top space (31) of a closed container (30) through the inspection area; and is characterised in that it comprises means (41) for identifying signal contributions useful for the pressure measurement amongst the data representative of an absorption spectrum acquired during the signal acquisition time period.