The invention encompasses compositions and compounds for inhibiting CoV2 Spike GP and human ACE2 proteins and a 3D pharmacophore model described herein provides the means for rapid, high-throughput virtual screening of potential anti-CoV2 modulators thus facilitating, optimizing and speeding up the search for the discovery of a potent anti-COVID-19 agent and methods of treatment and prevention thereof.

An apparatus includes a piston cavity, a piston insertable in the piston cavity, and at least one flow cavity. Each flow cavity is inserted in the piston, alongside the piston cavity such that the flow cavity has a connection with the piston cavity, or between the piston and a wall of the piston cavity by means of one or more differences in cross section between the piston and the piston cavity, and the flow cavity is in contact with a liquid substance being processed. The piston moves back and forth inside the piston cavity and causes with its movement a flow of the liquid substance in each flow cavity in connection with measuring the liquid substance.

Disclosed is a microorganism inoculation device, which comprises a workbench, wherein support columns are provided on the upper surface of the workbench, a limiting plate is provided in the middle part of the supporting column, an injection head is provided in the middle part of the limiting plate, an air cylinder is provided in the middle part of the lower surface of the workbench, a piston rod of the air cylinder is fixedly connected with the middle part of the upper surface of a lifting plate, guide rods are provided on the upper surface of the lifting plate, the upper end of the guide rod is fixedly connected with a tray, the left and right sides of the upper surface of the tray are fixedly connected with the lower part of a fixed bracket, the middle part of the injection head is slidably connected with the limiting plate.

A sampling device is provided, including: a syringe barrel having an opening and a holding portion; a plunger body having a protruding wall and disposed in the syringe barrel through the opening, where the protruding wall has a first recessed portion; a spring disposed around the plunger body; and a fastening assembly having an engaging structure for engaging the fastening assembly with the holding portion, a groove rail for receiving the protruding wall of the plunger body and a fastening portion for limiting displacement of the plunger body. A semi-automatic sample feeding device is further provided and includes the sampling device and a flow control device, and a test paper detection system is also provided and includes the semi-automatic sample feeding device and a test paper device. The test paper detection system is able to stably introduce samples, suitable for large-volume samples, which meets the needs of point-of-care applications.

A tube segment sampler system (10) for withdrawing a fluid sample from a tube segment (100), the sampler (10) having a first tube piercing member (28) for piercing the tube segment at a first location and a second tube piercing member (28) for piercing the tube segment at a second location so as to allow air to be drawn into the tube segment (100) through one of the openings made by one of the piercing members (28) whilst fluid is withdrawn through the other of the openings.

This disclosure is directed to a device and a system for aspirating and dispensing a target analyte, target material, or fluid. A picker may aspirate and dispense the desired material by introducing a pressure gradient. The picker may include a hydraulic fluid to hydraulically couple at least two components, such as a moveable pump component and a cannula.

A servo-electric actuated sampler can draw samples of fuel liquid from an operating main line. The sampler can run in a fast-loop process whereby liquid is drawn into the sampling system and past an actuated sampler and then out of the system back into main. The system main run a short loop whereby the main fast-flow is restricted, and the actuator and sampler are isolated from the main line flow. When isolated, the sampler discharges liquid into sampling cans. The servo-electric actuator requires a monitored amount of power to draw and discharge fluids. Monitoring of the power requirements of the servo-electric sampler can reveal the status and reliability of the system.

A pipette has a first chamber and a second chamber that connects to the first chamber and extends with an outlet channel to a pipette tip. The chambers are separated from one another by a longitudinally displaceable piston having a piston non-return valve. The second chamber has a chamber non-return valve which is arranged upstream of the outlet channel. An associated method includes recirculating the liquid in the first chamber, filling the first chamber with the liquid via a direct feed line, filling the second chamber with the liquid from the first chamber by pulling back the piston in the filling position toward the first chamber with the piston non-return valve open and with the chamber non-return valve closed, and emptying the second chamber by advancing the piston in the emptying position towards the outlet channel, with the piston non-return valve closed and the chamber non-return valve open.

The present application is directed to a sampling system for sampling a fluid from a vessel, where the sampling system includes a sterile dispenser assembly operatively connected to the vessel, the sterile dispenser assembly including a valve operatively connected to the vessel, a membrane, and a needle, and a detachable sterile sampling container assembly operatively connected to the sterile dispenser assembly, the detachable sterile sampling container assembly including a sampling container, a membrane attached to the sampling container, and a sampling container housing enclosing the sampling container, where the sampling container housing includes a compressible portion having a deflated configuration and an expanded configuration.

An object of the present invention is to provide a dispensing device that can inhibit a dead volume from occurring and can dispense a liquid of a small quantity with a high degree of accuracy while reducing the variation of dispensing quantities. A dispensing device according to the present invention has a detachable dispensing tip and the dispensing tip has a configuration of arranging a plunger in a hollow part of a metal pipe (refer to FIG. 2).