The invention relates to a liquid sampling device a support structure having a liquid reception interface that is in fluid communication with a reservoir chamber and a microfluidic valve, the microfluidic valve being connected to a measuring chamber. The liquid reception interface, the reservoir chamber and the microfluidic valve are configured to allow liquid entering the liquid reception interface to flow into the reservoir chamber while being prevented from passing the microfluidic valve unless a predetermined static pressure difference over the microfluidic valve is exceeded. The microfluidic valve is a passive valve without moving parts. Passing of liquid through the microfluidic valve is controlled by a static pressure difference over the microfluidic valve. The reservoir chamber is configured and arranged to cause high enough a static pressure at an entrance side of the microfluidic valve that causes a flow of liquid through the microfluidic valve into the measuring chamber once the reservoir chamber is completely filled.

A sampling probe, system and analysis method is disclosed. The sampling probe in one embodiment is constructed of a silicon substrate having a first channel, a second channel, a first tapered tip with an opening, and a second tapered tip with an opening, wherein the first channel extends from the first tapered tip opening to the second tapered tip opening, and wherein the second channel extends from an inlet port to a junction with the first channel.

A surface wipe for the detection of harmful substances on surfaces by producing uniform color change and a color comparator to determine the concentration of harmful substance collected on the wipe by comparing the intensity and hue of the uniform color on the wipe to a calibrated color scale related to specific concentration of the target harmful substance. In operation, the wipe is held from the handle to swipe a suspect surface. The pressure applied by fingers at certain areas on the rigid or flexible top support member of the wipe during the swiping process is transferred to the flexible wipe body. The flexible body of the wipe uniformly distribute the pressure applied by fingers throughout its mass and/or take the shape of irregular and uneven surface allowing the collection and color forming assembly to produce uniform color change that can be quantified by the color comparator.

Devices that can transport biological materials are described. The devices incorporate capillary channeled fibers that can effectively transport living cells as well as other biological materials such as nutrients, growth factors, waste materials, etc. The devices can include a sorptive material at one end of the fibers that can improve transport of materials through the devices. The devices can differentially transport different cell types, particularly when the fibers are held in a vertical orientation. Diagnostic devices that incorporate the capillary channeled fibers are described that can be utilized to separate cell types from one another. Tissue engineering scaffolds that incorporate the capillary channeled fibers are described that can more efficiently transport materials into and out of the scaffolds.

Embodiments in accordance with the present disclosure are directed to sample collecting and dispensing methods and apparatuses. An example apparatus includes a capillary sampler disposed on a device first end, wherein the capillary sampler is configured to collect a fluid sample via an opening and a capillary body. The apparatus further includes a reagents chamber in fluid communication with the capillary sampler, and a barrier assembly disposed between the capillary sampler and the reagents chamber, wherein the barrier assembly is configured to separate fluid in the reagents chamber from the capillary sampler. A plunger assembly disposed on a device second end opposite the device first end, may modify the barrier assembly to dispense the fluid from the reagents chamber to the capillary sampler responsive to application of a force in the direction of the device first end.

A device including a casing first part; a casing second part; a test strip having a sample pad; and a capillary sample collector, wherein the capillary sample collector has an open distal end configured to collect a fluid sample by capillary action and an open proximal end configured to dispense the fluid sample therefrom, wherein, the device is assembled such that the casing first part and the casing second part are joined, wherein a distal end of the casing first part and a distal end of the casing second part are sealed together in a fluid-tight manner, wherein the sample pad is positioned in proximity to the capillary dispensing end, wherein the dispensing end is positioned such that a dispensed fluid sample will be dispensed onto the sample pad, and wherein a dispensing angle between the dispensing and the sample pad of the test strip is less than 10 degrees.

An integrated device for a sample collection and transfer is provided. The integrated device comprises a capillary channel disposed between a first layer and a second layer, wherein the first layer comprises a hydrophilic layer comprising a fluid inlet for receiving a sample fluid to the capillary channel, wherein the capillary channel comprises an inner surface and an outer surface and an outlet for driving out the sample fluid. The device further comprises an interface assembly comprising: a third layer, a fourth layer, a fifth layer, and a flow path. The interface assembly is disposed on the outer surface of the capillary, at a determining position relative to the outlet, such that the capillary is in contact with the third layer of the interface assembly and the outlet is in contact with the flow path of the interface assembly for driving out the sample fluid from the integrated device.

An apparatus for sample handling and processing is disclosed. The apparatus can comprise a sample collector, a reagent reservoir configured to hold a reagent, and a separator disposed between the reagent reservoir and the sample collector. The apparatus can comprise an actuator being movable from a start position to a dispense position to modify the separator to open a fluid flow path from the reagent reservoir to the sample collector and dispense the sample and the reagent through the sample collector. A method of sample handling and processing is also disclosed. The method can comprise collecting a sample, moving an actuator to modify a separator sealing a reagent reservoir to open a flow path from the reagent reservoir to the sample collector and dispense the sample and the reagent through the sample collector. A system for sample handling, processing and detecting is further disclosed.

Coextruded plastic capillary tube and method of manufacturing a coextruded tube for collecting a volume of liquid. The tube is disposable, inexpensive to manufacture and can reliably draw blood and other aqueous based fluids into the tube by capillary action, at a fluid uptake level comparable to glass and other commercially pre-treated plastic tubes, without requiring further interior coating.

Devices and methods for use in extraction procedures of analytes (organic and inorganic, including heavy metals) from matrices (e.g., complex matrices) in various fields (e.g., biological, clinical, chemical, environmental, toxicological, and forensic) are provided. The device can comprise a support structure acting as a rigid and stable support for extraction materials that can be inserted thereinto. The device can comprise a plurality of windows in the support structure through which the extraction materials can be exposed. The device can include two portions that can join together (e.g., using an interlocking system).