The invention relates the use of single particle light scattering, preferably interferometric scattering microscopy (also referred to herein as iSCAT), to measure the concentration of a particle in a solution. The invention furthermore relates to the use of light scattering to detect lipoprotein particles in a sample, and to related diagnostic and treatment methods.

An opto-mechanical analysis device for determining particulate matter in a measurement gas includes a first light source, a measurement chamber, a plurality of detectors, a control device, an optical reference measurement element and a displacement unit. A first light of the first light source can be coupled into the measurement chamber. The detectors are configured to receive scattered light that is produced on the incidence of the first light on the particulate matter and to generate scattered light measurement data which is transmitted to the control device. The displacement unit is configured to displace the optical reference measurement element from a parking position into a reference measurement position where the first light can be radiated into the optical reference measurement element. The detectors are configured to receive scattered light from the optical reference measurement element and to generate reference measurement data and to transmit said data to the control device.

The invention relates the use of single particle light scattering, preferably interferometric scattering microscopy (also referred to herein as iSCAT), to measure the concentration of a particle in a solution. The invention furthermore relates to the use of light scattering to detect lipoprotein particles in a sample, and to related diagnostic and treatment methods.

A system comprising at least one light source configured to generate a light at specific wavelengths and project the light over an optical path, a sample device, the sample device configured to receive a sample obtained from a person, the sample device being transparent and being at least partially within the optical path, a diversifier including occlusions for scattering coherent light received from the light source along the optical path, a first detector configured to receive the light over the optical path and from at least a portion of the diversifier, the detector configured to detect spectral intensities of the light, and a second detector configured to receive at least a portion of the light form the optical path before the light passes through the diffuser, the second detector configured to detect spectral intensities of the light.

A method and automated apparatus for locating and selecting a colony of microorganisms on a culture dish and subjecting the obtained sample to a plurality of downstream tests including a test to identify the microorganism and a test to identify the susceptibility of the microorganism to antibiotics. The method includes the automated steps of locating and selecting a colony of microorganisms on a culture dish; obtaining a sample of the selected colony of microorganisms; preparing a suspension of a sample of microorganisms automatically by submerging the pick tool with the sample in a suspension, after which the pick tool is vibrated in at least the vertical direction to release the sample from the pick tool in the suspension. The turbidity of the suspension is monitored to ensure that the concentration of microorganism in suspension is sufficient so that the suspension is used a source for sample for both identification and antibiotic susceptibility of the microorganisms in the sample. The apparatus and system optionally provide for downstream processing of samples prepared for antibiotic susceptibility testing (AST). Such apparatus includes further processing after inoculation of an AST panel for the AST test. Such further processing includes capping and transferring inoculated panels to AST instrument.

The present disclosure describes an apparatus, method, system, and computer program product of identifying a cuvette for measuring light scattering of a sample. In an exemplary embodiment, the apparatus includes at least one sensor configured to detect at least one shape feature of a cuvette, and an insulating block configured to maintain a temperature of the at least one sensor within an operating temperature range of the at least one sensor. In an exemplary embodiment, the method, system, and computer program product include receiving a first set of signals from a first sensor directed to a cuvette, receiving a second set of signals from a second sensor directed to the cuvette, and executing a set of logical operations detecting a shape feature of the cuvette.

Provided is a turbidity meter including a main body, a fluid container which is formed inside the main body and in which a fluid is accommodatable, a fluid inlet pipe which is connected to the fluid container and via which the fluid is supplied to the fluid container, a fluid outlet pipe which is connected to the fluid container and via which the fluid is discharged from the fluid container to the outside, a wave source configured to irradiate waves toward the fluid container, a detector configured to detect a laser speckle at every time point set in advance, the laser speckle being generated due to multiple scattering of the irradiated waves in the fluid, and a controller configured to estimate the presence or absence of impurities in the fluid in real-time by using the detected laser speckle.

The present invention is a cuvette assembly for use in optically measuring at least one characteristic of particles within a plurality of liquid samples. The cuvette assembly comprises a main body having internal walls and external walls, and a plurality of cuvettes within the main body at least partially being defined by the internal walls. Each of the plurality of cuvettes has a liquid-input chamber for receiving a respective one of the plurality of liquid samples, a filter, and an optical chamber for receiving a respective filtered liquid sample caused by passing the respective one of the plurality of liquid samples through the filter. Each of the optical chambers includes an entry window for allowing transmission of an input light beam through the filtered liquid sample and an exit window for transmitting a forward scatter signal caused by the particles within the filtered liquid sample.

A measuring cell for performing optical measurements of a medium disposed in the measuring cell includes: recesses extending through a first outer wall and a second outer wall of the measuring cell; and two window mounts, each with a transparent window therein and each including outward protruding projections configured to be inserted a corresponding recess at a selected installation depth, wherein a wall of the measuring cell that surrounds the recess includes on an inside, for each selectable installation depth, one set of contact surfaces arranged around the recess in a radial direction such that the projections of the window mount seat on the contact surfaces of the corresponding set, which are arranged in an axial direction such that the window mount is arranged in the recess at the selected installation depth.

A system comprising at least one light source configured to generate a light at specific wavelengths and project the light over an optical path, a sample device, the sample device configured to receive a sample obtained from a person, the sample device being transparent and being at least partially within the optical path, a diversifier including occlusions for scattering coherent light received from the light source along the optical path, a first detector configured to receive the light over the optical path and from at least a portion of the diversifier, the detector configured to detect spectral intensities of the light, and a second detector configured to receive at least a portion of the light form the optical path before the light passes through the diffuser, the second detector configured to detect spectral intensities of the light.