The present disclosure relates to a biological detection chip and a detecting method thereof. The biological detection chip includes a light guiding substrate having a top surface, a bottom surface opposite to the top surface, and a side surface between the top surface and the bottom surface, and a biosensitive membrane on the top surface of the light guiding substrate.

A method and system for optical detection and identification of pathogens in a thin layer of fluid, are provided herein. The system may include: a consumable part comprising: a fluid reservoir; a pathogen trap in fluid communication with the fluid reservoir; and a base attached to the fluid reservoir; and an electro-optical part comprising: a generally coherent light source for directing a generally a coherent light beam at the flat surface at an angle selected to cause total internal reflection of the generally coherent light beam at the surface and an evanescent wave penetrating the fluid; a camera facing the surface for capturing light scattering being scattered off the pathogens on the pathogen trap due to an interaction with the evanescent wave, forming a speckle image; and a computer processor configured to analyze the speckle image, to detect and identify pathogens in a fluid inserted into the fluid reservoir.

An oxygen scanning device includes a console unit. The console unit includes a light source emitting excitation radiation and a detector configured to receive and detect phosphorescence radiation. The device includes a needle sensor operably, optically coupled to the console unit by an optical fiber movably received within a transparent tube housing the optical fiber, the transparent tube being coated by an oxygen-sensitive dye material on an outer side thereof. The optical fiber is terminated by a 45 degree reflecting surface at a distal end thereof wherein excitation radiation is directed to the oxygen sensitive dye material and phosphorescence radiation from the oxygen sensitive material is returned from the oxygen sensitive material to the detector.

The invention is a SPR sensor that comprises a multi-layered plasmonic structure on a substrate for sensing. The SPR sensor has an enhanced figure of merit and lower limit of detection (system noise divided by the sensitivity) by at least two orders of magnitude than prior art SPR sensors. The plasmonic structure of the invention comprises a Nanostructured Porous Metal Layer (NPML) and at least one of: (a) buried dielectric layer under the nano-porous metal layer; (b) a nano-dimensional high index layer on top of the metal layer; and (c) a molecular layer for bio-functionalization adjacent to an analyte layer. The invention also encompasses many embodiments of measuring systems that comprise the SPR sensors of the invention with improved signal to noise ratio.

Disclosed herein are embodiments of sensor devices comprising a sensing component able to determine the presence of, detect, and/or quantify detectable species in a variety of environments and applications. The sensing components disclosed herein can comprise MOF materials, plasmonic nanomaterials, or combinations thereof. In an exemplary embodiment, light guides can be coupled with the sensing components described herein to provide sensor devices capable of increased NIR detection sensitivity in determining the presence of detectable species, such as gases and volatile organic compounds. In another exemplary embodiment, optical properties of the plasmonic nanomaterials combined with MOF materials can be monitored directly to detect analyte species through their impact on external conditions surrounding the particle or as a result of charge transfer to and from the plasmonic material as a result of interactions with the plasmonic material and/or the MOF material.

A sensor using thermally emissive materials for chemical spectroscopy analysis includes an emissive material, wherein the emissive material includes the thermally emissive materials which emit electromagnetic radiation, wherein the electromagnetic radiation is modified due to chemical composition in an environment; and a detector adapted to detect the electromagnetic radiation, wherein the electromagnetic radiation is indicative of the chemical interaction changes and hence chemical composition and/or chemical composition changes of the environment. The emissive material can be utilized with an optical fiber sensor, with the optical fiber sensor operating without the emissive material probed with a light source external to the material.

Presented herein are methods, systems, and apparatus for single analyte detection or multiplexed analyte detection based on amplified luminescent proximity homogeneous assay (alpha) technology, but using hollow polymer fiber optics doped with acceptor bead dye (e.g., thioxene, anthracene, rubrene, and/or lanthanide chelates) or donor bead dye (e.g., phthalocyanine) that carry a signal generated by the dopant via singlet oxygen channeling.

Systems for analyte detection are disclosed. The system includes absorption channels positioned along a surface of an object. The absorption channels are configured to trap an analyte. The system further includes a sensor embedded in the object and configured to detect the presence of the analyte. The sensor includes a light source configured to transmit light and a detector configured to detect a change in an intensity of light transmitted by the light source. The sensor further includes a cable configured to connect the light source to the detector, wherein the cable comprises detection regions, and wherein the detection regions include a portion of the cable exposed to the analyte in the absorption channel.

A scanning sensor system, methods of use and kits for detecting a biologically active analyte are provided. The scanning senor system includes a light source, a detector, a substrate comprising a plurality of waveguides and a plurality of optical sensing sites in optical communication with one or more waveguide of the substrate, and at least one adapter configured to couple with the substrate and provide optical communication between the light source, the waveguides of the substrate, and the detector.

A method and system for optical detection and identification of pathogens in a thin layer of fluid, are provided herein. The system may include: a consumable part comprising: a fluid reservoir; a pathogen trap in fluid communication with the fluid reservoir; and a base attached to the fluid reservoir; and an electro-optical part comprising: a generally coherent light source for directing a generally a coherent light beam at the flat surface at an angle selected to cause total internal reflection of the generally coherent light beam at the surface and an evanescent wave penetrating the fluid; a camera facing the surface for capturing light scattering being scattered off the pathogens on the pathogen trap due to an interaction with the evanescent wave, forming a speckle image; and a computer processor configured to analyze the speckle image, to detect and identify pathogens in a fluid inserted into the fluid reservoir.