Disclosed are a biochip capable of detecting and analyzing multivalent bindings between target protein and binding mediator from monovalent bindings and a method for manufacturing the same. A biochip according to an embodiment comprises: a hydrogel functional layer on which a binding mediator is formed and of which physical properties are changed by a reaction between target protein to be introduced and the binding mediator; and a transducer configured to deliver a displacement signal corresponding to a change in the physical properties of the hydrogel functional layer to an analysis instrument, wherein the reaction is multivalent bindings between the target protein and the binding mediator, and de-swelling occurs in at least a portion of the hydrogel functional layer by the multivalent bindings.

A package damage inspection device according to an exemplary embodiment of the present invention may include: a sensor recognizing internal environmental change information of a sealed container; an identification element including an identification code of the sealed container; a recognizing unit recognizing the identification code included in the identification element to recognize identification information of the sealed container; and a determining unit comparing the internal environmental change information recognized by the sensor and reference change information with each other to determine whether or not the sealed container is maintained in a sealed state.

A system and method for determining concentration of a constituent of a sample fluid includes a flow cell with a light source emitting incident light to a proximal end thereof. Media disposed within the flow cell supports nanostructures that are substantially transparent in at least a portion of the incident light spectrum. The nanostructures adsorb or absorb the constituent to attain a concentration that is a multiple of the concentration of the constituent in the sample fluid. A sensor detects transmitted light exiting from the media, and generates outputs corresponding to a spectrum of the transmitted light. A processor captures the sensor outputs and compares the incident light spectrum to the transmitted light spectrum to generate an absorbance spectrum. The absorbance spectrum is used to calculate the concentration in the nanostructures, which is then used with the predetermined multiple to calculate the sample concentration.

A scour monitoring system may provide a housing that is separated into multiple segments that are fluidically isolated from each other. The scour monitoring system may be position adjacent to a structure to be monitored for bridge scouring. Each of the segments may provide a water-swellable material positioned near or in contact with a fiber Bragg grating (FBG) cable. If water penetrates a segment, the water-swellable material may expand to deform the FBG cable. The wavelength of the FBG cable may be monitored periodically for changes, thereby providing moisture detection when a change in wavelength is detected.

A nanosensor for detecting an analyte can include a substrate, a photoluminescent nanostructure, and a polymer interacting with the photoluminescent nanostructure. The nanosensor can be used in in vivo for biomedical applications.

A sensor system, and a method of detecting a target analyte, comprises a chemically functionalized block copolymer, and a target analyte. The block copolymer exhibits a color change in the visible spectrum upon exposure to the target analyte.

The present disclosure relates to a tissue diagnosis device including a plate supporter configured to support a plate on which a reaction region is placed and a sample is placed in the reaction region, a patch controller configured to support the patch which contains a labeling substance that specifically labels the target substance, and control a position of the patch relative to the reaction region so that the patch provides the labeling substance to the reaction region, and a target substance detector configured to detect the labeling substance and detect the target substance included in the tissue sample.

The present disclosure relates to a gel-phase patch that performs a function of assisting in staining during a staining process such as a process of coming into contact with a specimen such as blood to perform a staining function of staining the specimen, a process of fixing the specimen, or a process of forming an optimal pH at a specimen stained by a staining sample. According to an aspect of the present disclosure, a contact-type staining patch includes a staining solution that reacts with a specimen and a gel receptor provided as a gel matrix of a mesh structure in which a pore that accommodates the staining solution is formed and the mesh structure prevents the staining solution in the pore from leaking or degenerating, and having a contact surface that comes into contact with the specimen to transfer some of the staining solution to the specimen.

An optical sensor arrangement for measuring an observable including at least one light source for generating a first light component of a first frequency including a first mode and a second light component of a second frequency including a second mode orthogonal to the first mode, an optical resonator having differing optical lengths for the first and second modes, at least one of the optical lengths being variable depending on the observable and a dependence of the respective optical length being different for the first and second modes, and a detector unit coupled to the optical resonator for coupling out the two light components and being configured for detecting a frequency difference between a resonance frequency of the optical resonator for the first mode and a resonance frequency of the optical resonator for the second mode.

The present disclosure relates to a tissue diagnosis device including a plate supporter configured to support a plate on which a reaction region is placed and a sample is placed in the reaction region, a patch controller configured to support the patch which contains a labeling substance that specifically labels the target substance, and control a position of the patch relative to the reaction region so that the patch provides the labeling substance to the reaction region, and a target substance detector configured to detect the labeling substance and detect the target substance included in the tissue sample.