Presented herein are methods, systems, and apparatus for single analyte detection or multiplexed analyte detection based on amplified luminescent proximity homogeneous assay (alpha) technology, but using hollow polymer fiber optics doped with acceptor bead dye (e.g., thioxene, anthracene, rubrene, and/or lanthanide chelates) or donor bead dye (e.g., phthalocyanine) that carry a signal generated by the dopant via singlet oxygen channeling.